HK1244783A1 - 製造曲前列素和曲前列素衍生物的前藥的方法 - Google Patents

製造曲前列素和曲前列素衍生物的前藥的方法

Info

Publication number
HK1244783A1
HK1244783A1 HK18104145.6A HK18104145A HK1244783A1 HK 1244783 A1 HK1244783 A1 HK 1244783A1 HK 18104145 A HK18104145 A HK 18104145A HK 1244783 A1 HK1244783 A1 HK 1244783A1
Authority
HK
Hong Kong
Prior art keywords
treprostinil
manufacturing
methods
derivative prodrugs
prodrugs
Prior art date
Application number
HK18104145.6A
Other languages
English (en)
Inventor
Vladimir Malinin
Walter Perkins
Franziska Leifer
Donna M Konicek
Zhili Li
Adam Plaunt
Original Assignee
Insmed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insmed Inc filed Critical Insmed Inc
Publication of HK1244783A1 publication Critical patent/HK1244783A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK18104145.6A 2014-11-18 2018-03-26 製造曲前列素和曲前列素衍生物的前藥的方法 HK1244783A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462081515P 2014-11-18 2014-11-18
PCT/US2015/061427 WO2016081658A1 (en) 2014-11-18 2015-11-18 Methods of manufacturing treprostinil and treprostinil derivative prodrugs

Publications (1)

Publication Number Publication Date
HK1244783A1 true HK1244783A1 (zh) 2018-08-17

Family

ID=56014536

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18104145.6A HK1244783A1 (zh) 2014-11-18 2018-03-26 製造曲前列素和曲前列素衍生物的前藥的方法

Country Status (8)

Country Link
US (4) US10343979B2 (zh)
EP (2) EP3221291B1 (zh)
JP (1) JP6866043B2 (zh)
AU (1) AU2015349969B2 (zh)
CA (1) CA2967385C (zh)
ES (1) ES2873873T3 (zh)
HK (1) HK1244783A1 (zh)
WO (1) WO2016081658A1 (zh)

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Also Published As

Publication number Publication date
US11148997B2 (en) 2021-10-19
AU2015349969B2 (en) 2020-02-06
US20190337888A1 (en) 2019-11-07
AU2015349969A1 (en) 2017-05-25
EP3221291B1 (en) 2021-03-31
EP3904326A1 (en) 2021-11-03
CA2967385A1 (en) 2016-05-26
JP2017535555A (ja) 2017-11-30
US20230250051A1 (en) 2023-08-10
US20170320813A1 (en) 2017-11-09
EP3221291A4 (en) 2018-06-27
CA2967385C (en) 2023-05-16
ES2873873T3 (es) 2021-11-04
US20220135513A1 (en) 2022-05-05
US10343979B2 (en) 2019-07-09
JP6866043B2 (ja) 2021-04-28
WO2016081658A1 (en) 2016-05-26
EP3221291A1 (en) 2017-09-27

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