HK1226097A1 - Rna轉錄載體及其用途 - Google Patents

Rna轉錄載體及其用途

Info

Publication number
HK1226097A1
HK1226097A1 HK16114308A HK16114308A HK1226097A1 HK 1226097 A1 HK1226097 A1 HK 1226097A1 HK 16114308 A HK16114308 A HK 16114308A HK 16114308 A HK16114308 A HK 16114308A HK 1226097 A1 HK1226097 A1 HK 1226097A1
Authority
HK
Hong Kong
Prior art keywords
rna transcription
transcription vector
vector
rna
transcription
Prior art date
Application number
HK16114308A
Other languages
English (en)
Inventor
Carlo Heirman
Kristiaan Thielemans
Original Assignee
Univ Brussel Vrije
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brussel Vrije filed Critical Univ Brussel Vrije
Publication of HK1226097A1 publication Critical patent/HK1226097A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/10—Vectors comprising a non-peptidic targeting moiety
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105—Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
HK16114308A 2013-11-12 2016-12-15 Rna轉錄載體及其用途 HK1226097A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13192555 2013-11-12

Publications (1)

Publication Number Publication Date
HK1226097A1 true HK1226097A1 (zh) 2017-09-22

Family

ID=49578161

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16114308A HK1226097A1 (zh) 2013-11-12 2016-12-15 Rna轉錄載體及其用途

Country Status (20)

Country Link
US (3) US10159755B2 (zh)
EP (2) EP3336192B1 (zh)
JP (2) JP6530393B2 (zh)
KR (2) KR102396589B1 (zh)
CN (2) CN105849269B (zh)
AU (1) AU2014350222B2 (zh)
CA (2) CA3191243A1 (zh)
DK (2) DK3336192T3 (zh)
EA (1) EA035313B1 (zh)
ES (2) ES2908268T3 (zh)
HK (1) HK1226097A1 (zh)
HU (2) HUE058792T2 (zh)
IL (1) IL245596B (zh)
MX (1) MX2016006134A (zh)
NO (1) NO3068888T3 (zh)
NZ (1) NZ720885A (zh)
PL (2) PL3068888T3 (zh)
PT (2) PT3336192T (zh)
SG (1) SG11201603482RA (zh)
WO (1) WO2015071295A1 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
CA2935960C (en) 2014-01-08 2023-01-10 Bart Lipkens Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
EP3334828B1 (en) 2015-08-10 2020-10-28 CureVac Real Estate GmbH Method of increasing the replication of a circular dna molecule
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
JP2020513248A (ja) 2016-10-19 2020-05-14 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響による親和性細胞抽出
BR112020009889A2 (pt) 2017-12-14 2020-11-03 Flodesign Sonics, Inc. acionador e controlador de transdutor acústico
MX2021008126A (es) 2019-01-04 2021-09-23 Etherna Immunotherapies Nv Vacuna de arnm.
KR20220007850A (ko) * 2019-03-13 2022-01-19 이더알엔에이 이뮤노테라피스 엔브이 Mrna 백신
KR20220023340A (ko) 2019-04-26 2022-03-02 이더알엔에이 이뮤노테라피스 엔브이 mRNA 제형
MX2021015802A (es) 2019-06-27 2022-04-01 Etherna Immunotherapies Nv Terapia de combinacion.
TW202139975A (zh) 2020-01-21 2021-11-01 比利時商ｅＴｈｅＲＮＡ免疫治療公司 脂質奈米顆粒
CN115443148A (zh) * 2020-02-14 2022-12-06 伊泽阿恩埃免疫疗法股份有限公司 鼻内mRNA疫苗
EP4164596A1 (en) 2020-06-11 2023-04-19 eTheRNA Immunotherapies NV Lipid nanoparticles
KR20230116700A (ko) * 2022-01-27 2023-08-04 에스케이바이오사이언스(주) 단백질 발현을 위한 mRNA와 이를 위한 주형
KR102624969B1 (ko) * 2023-04-03 2024-01-16 한국과학기술원 mRNA 번역 증가를 유도하는 mRNA 3'UTR 서열

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
US5861240A (en) * 1996-02-28 1999-01-19 The Regents Of The University Of California Isolated human herpesvirus type 8 sequences and uses thereof
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US7183395B2 (en) * 2000-01-28 2007-02-27 The Scripps Research Institute Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions relating to same
US7468275B2 (en) * 2000-01-28 2008-12-23 The Scripps Research Institute Synthetic internal ribosome entry sites and methods of identifying same
US7608699B2 (en) * 2003-12-29 2009-10-27 Rockefeller University Synthetic nuclear localization signal derived from lentiviral integrase and methods of use thereof
CA2568781C (en) * 2004-06-04 2014-07-29 Centre National De La Recherche Scientifique Intrathymic administration of viral vectors for the induction of immune tolerance, the prevention or treatment of immunodeficiencies or autoimmune diseases
JP4964493B2 (ja) * 2006-04-28 2012-06-27 株式会社カネカ 内部リボソーム結合部位を利用した遺伝子組換え全抗体の効率的生産法
DK2201100T3 (en) * 2007-09-14 2016-05-30 Univ Bruxelles IMPROVING THE T-CELL STIMULATING ABILITY OF HUMAN antigen presenting cells AND USE THEREOF IN THE VACCINATION
SG10201408162PA (en) * 2007-12-11 2015-01-29 Scripps Research Inst Compositions and methods related to mrna translational enhancer elements
CN101952435A (zh) * 2008-02-01 2011-01-19 塞瑞斯公司 启动子、启动子控制元件及其组合和用途

Also Published As

Publication number Publication date
ES2908268T3 (es) 2022-04-28
HUE038831T2 (hu) 2018-11-28
CA3191243A1 (en) 2015-05-21
JP2016537978A (ja) 2016-12-08
PT3336192T (pt) 2022-03-10
BR112016010595A2 (pt) 2017-12-05
IL245596B (en) 2019-10-31
NZ720885A (en) 2022-02-25
PT3068888T (pt) 2018-04-24
AU2014350222B2 (en) 2020-02-27
CN105849269A (zh) 2016-08-10
PL3068888T3 (pl) 2018-07-31
EA201690965A1 (ru) 2016-09-30
US20160279266A1 (en) 2016-09-29
SG11201603482RA (en) 2016-05-30
WO2015071295A1 (en) 2015-05-21
NO3068888T3 (zh) 2018-06-30
KR102267412B1 (ko) 2021-06-21
KR20160090317A (ko) 2016-07-29
MX2016006134A (es) 2017-01-20
US20210060182A1 (en) 2021-03-04
ES2666380T3 (es) 2018-05-04
HUE058792T2 (hu) 2022-09-28
EP3068888A1 (en) 2016-09-21
DK3068888T3 (en) 2018-05-07
DK3336192T3 (da) 2022-03-14
EP3336192B1 (en) 2021-12-08
EA035313B1 (ru) 2020-05-27
AU2014350222A1 (en) 2016-06-23
JP6530393B2 (ja) 2019-06-12
JP6900054B2 (ja) 2021-07-07
KR102396589B1 (ko) 2022-05-10
CA2929203A1 (en) 2015-05-21
EP3336192A1 (en) 2018-06-20
PL3336192T3 (pl) 2022-04-04
CN111621524A (zh) 2020-09-04
KR20210076181A (ko) 2021-06-23
EP3068888B1 (en) 2018-01-31
CN105849269B (zh) 2020-07-17
US10159755B2 (en) 2018-12-25
IL245596A0 (en) 2016-06-30
US10864284B2 (en) 2020-12-15
CA2929203C (en) 2023-04-18
JP2019146589A (ja) 2019-09-05
US20180353625A1 (en) 2018-12-13

Similar Documents

Publication Publication Date Title
HK1226097A1 (zh) Rna轉錄載體及其用途
IL269461B (en) Cytidine-5-carboxamide modified nucleotide preparations and related methods
ZA201602510B (en) Strigolactone formulations and uses thereof
EP2972349A4 (en) POLYMER POINT COMPOSITIONS AND CORRESPONDING METHODS
IL245839B (en) Inhibitors of rna polymerase i and use of preparations containing them for treatment
EP2918681A4 (en) FERTILITY GENE AND USES THEREOF
EP3048538A4 (en) Vector operation core and vector processor
IL240248A0 (en) Met-binding substances and their uses
EP2988742A4 (en) THIAZOLES AND USES THEREOF
AP2016009207A0 (en) Genetic markers and uses therefor
HK1231503A1 (zh) 基因突變體及其應用
SG11201600235TA (en) Castings and manufacture methods
GB201309178D0 (en) Enzyme and uses thereof
GB201320992D0 (en) Complex and uses thereof
EP2970895A4 (en) PODOCYTIC CULTURES AND USES THEREOF
WO2014202624A9 (en) Rasamsonia gene and use thereof
GB201305297D0 (en) Novel agents and uses thereof
ZA201601880B (en) Hetero-transglycosylase and uses thereof
GB201304585D0 (en) Methods and product
GB201301393D0 (en) Kiddibidet and pottibidet
GB201318949D0 (en) Genes
GB201304166D0 (en) CelebQuiff and Instant Quiff
GB201309328D0 (en) Product and use thereof
GB201306435D0 (en) Vector
GB201301640D0 (en) Methods and peptides