HK1219234A1 - 新型呼吸控制调节化合物及其使用方法 - Google Patents

新型呼吸控制调节化合物及其使用方法 Download PDF

Info

Publication number
HK1219234A1
HK1219234A1 HK16107336.0A HK16107336A HK1219234A1 HK 1219234 A1 HK1219234 A1 HK 1219234A1 HK 16107336 A HK16107336 A HK 16107336A HK 1219234 A1 HK1219234 A1 HK 1219234A1
Authority
HK
Hong Kong
Prior art keywords
pyrimido
pyrimidine
propyl
tetramine
dimethyl
Prior art date
Application number
HK16107336.0A
Other languages
English (en)
Chinese (zh)
Inventor
‧達克斯
S‧达克斯
‧門塞爾
J‧J‧门塞尔
‧奧佐拉
V‧奥佐拉
‧舒賓
K‧舒宾
‧瑪諸葛
M‧玛诸葛
‧蘇娜
E‧苏娜
Original Assignee
加林制药公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 加林制药公司 filed Critical 加林制药公司
Publication of HK1219234A1 publication Critical patent/HK1219234A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Otolaryngology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
HK16107336.0A 2013-03-15 2014-03-13 新型呼吸控制调节化合物及其使用方法 HK1219234A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792185P 2013-03-15 2013-03-15
US61/792,185 2013-03-15
PCT/US2014/025792 WO2014151462A1 (en) 2013-03-15 2014-03-13 Novel breathing control modulating compounds, and methods of using same

Publications (1)

Publication Number Publication Date
HK1219234A1 true HK1219234A1 (zh) 2017-03-31

Family

ID=51580966

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16107336.0A HK1219234A1 (zh) 2013-03-15 2014-03-13 新型呼吸控制调节化合物及其使用方法

Country Status (14)

Country Link
US (1) US9643971B2 (enExample)
EP (1) EP2968329A4 (enExample)
JP (1) JP2016516714A (enExample)
KR (1) KR20150143498A (enExample)
CN (1) CN105209041A (enExample)
AU (1) AU2014234095A1 (enExample)
BR (1) BR112015023671A2 (enExample)
CA (1) CA2905950A1 (enExample)
EA (1) EA201591693A1 (enExample)
HK (1) HK1219234A1 (enExample)
MX (1) MX2015013137A (enExample)
SG (1) SG11201507140PA (enExample)
WO (1) WO2014151462A1 (enExample)
ZA (1) ZA201507064B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105340281B (zh) 2013-07-05 2019-06-28 索尼公司 发送装置、发送方法、接收装置和接收方法
NO346258B1 (en) * 2015-06-30 2022-05-16 Neurad Ltd Novel breathing control modulating compounds, and methods of making and using same
US20210244742A1 (en) * 2015-07-22 2021-08-12 John Hsu Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof
WO2021021236A1 (en) * 2019-07-26 2021-02-04 Heteron Biotechnologies, Llc Breath analyzer and urea breath test method
KR20260053367A (ko) * 2023-08-14 2026-04-21 뉴림 파머슈티칼스(1991) 리미티드 Gal475 조성물 및 그의 사용 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
JPS557430B2 (enExample) 1972-05-17 1980-02-25
US4963541A (en) 1989-02-22 1990-10-16 Abbott Laboratories Pyrimido-pyrimidine lipoxygenase inhibiting compounds
US5075290A (en) * 1989-06-28 1991-12-24 University Of Virginia Alumni Patents Foundation Use of adenosine, adenosine analogs or nucleoside uptake blockers, e.g. dipyridamole, as drug treatments for obstructive sleep apnea and snoring
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
US6232312B1 (en) * 1995-06-07 2001-05-15 Cell Pathways, Inc. Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
EP2061440A2 (en) * 2007-04-04 2009-05-27 Sigmoid Pharma Limited A pharmaceutical composition of tacrolimus
EP2646423A4 (en) 2010-11-29 2014-04-30 Galleon Pharmaceuticals Inc NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR THE TREATMENT OF RESPIRATORY DISORDERS OR DISEASES

Also Published As

Publication number Publication date
EA201591693A1 (ru) 2016-03-31
MX2015013137A (es) 2016-05-05
US9643971B2 (en) 2017-05-09
WO2014151462A4 (en) 2014-11-13
AU2014234095A1 (en) 2015-10-08
EP2968329A1 (en) 2016-01-20
SG11201507140PA (en) 2015-10-29
CA2905950A1 (en) 2014-09-25
ZA201507064B (en) 2017-01-25
EP2968329A4 (en) 2016-09-28
JP2016516714A (ja) 2016-06-09
KR20150143498A (ko) 2015-12-23
CN105209041A (zh) 2015-12-30
WO2014151462A1 (en) 2014-09-25
BR112015023671A2 (pt) 2017-07-18
US20160046635A1 (en) 2016-02-18

Similar Documents

Publication Publication Date Title
RU2734506C2 (ru) Новые модулирующие регуляцию дыхания соединения и способы их получения и применения
US20150291597A1 (en) Novel orally bioavailable breathing control modulating compounds, and methods of using same
WO2012166909A1 (en) Compositions and methods for treating breathing control disorders or diseases
US9643971B2 (en) Breathing control modulating compounds, and methods of using same
WO2009151744A1 (en) S-nitrosomercapto compounds and related derivatives
US20100105685A1 (en) S-Nitrosothiol Compounds and Related Derivatives
WO2025038783A1 (en) Adenosine ligands for the treatment of neurological disorders or chronic heart failure
US10543187B2 (en) Compositions and methods for stimulating ventilatory and/or respiratory drive
BR112017028487B1 (pt) Composto de modulação do controle da respiração e composição farmacêutica
NZ738082B2 (en) Novel breathing control modulating compounds, and methods of making and using same
CN107304180B (zh) 苯甲酰胺类衍生物、其制备方法及其在医药上的用途