HK1218421A1 - 抗胰高血糖素受體抗體和其使用方法 - Google Patents

抗胰高血糖素受體抗體和其使用方法

Info

Publication number
HK1218421A1
HK1218421A1 HK16106367.4A HK16106367A HK1218421A1 HK 1218421 A1 HK1218421 A1 HK 1218421A1 HK 16106367 A HK16106367 A HK 16106367A HK 1218421 A1 HK1218421 A1 HK 1218421A1
Authority
HK
Hong Kong
Prior art keywords
methods
glucagon receptor
receptor antibodies
antibodies
glucagon
Prior art date
Application number
HK16106367.4A
Other languages
English (en)
Inventor
‧查帕羅里格斯
‧福爾杰
‧拉瓦利
林家揚
‧莫夏科
‧羅西
‧范布拉科姆
Original Assignee
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rinat Neuroscience Corp filed Critical Rinat Neuroscience Corp
Publication of HK1218421A1 publication Critical patent/HK1218421A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK16106367.4A 2013-05-07 2016-06-03 抗胰高血糖素受體抗體和其使用方法 HK1218421A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361820604P 2013-05-07 2013-05-07
US201461981115P 2014-04-17 2014-04-17
PCT/IB2014/061166 WO2014181229A2 (en) 2013-05-07 2014-05-02 Anti-glucagon receptor antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1218421A1 true HK1218421A1 (zh) 2017-02-17

Family

ID=50884431

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16106367.4A HK1218421A1 (zh) 2013-05-07 2016-06-03 抗胰高血糖素受體抗體和其使用方法

Country Status (15)

Country Link
US (2) US9248189B2 (zh)
EP (1) EP2994489A2 (zh)
JP (1) JP2016520058A (zh)
KR (1) KR20160005749A (zh)
CN (1) CN105189560A (zh)
AU (1) AU2014264295A1 (zh)
CA (1) CA2911412A1 (zh)
HK (1) HK1218421A1 (zh)
MX (1) MX2015015339A (zh)
PE (1) PE20151871A1 (zh)
PH (1) PH12015502547A1 (zh)
RU (1) RU2015147721A (zh)
SG (1) SG11201508264UA (zh)
TW (2) TW201702274A (zh)
WO (1) WO2014181229A2 (zh)

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JP2018502084A (ja) * 2014-12-23 2018-01-25 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル ベータ細胞への変換と組み合わせられたアルファ細胞の再生
MX2017012694A (es) 2015-04-02 2018-03-07 Remb Biotherapeutics Inc Metodos para tratar la obesidad y la enfermedad del higado graso no alcoholica o esteatohepatitis no alcoholica utilizando anticuerpos antagonistas del receptor de glucagon.
WO2017055966A1 (en) 2015-10-01 2017-04-06 Pfizer Inc. Low viscosity antibody compositions
US20190062441A1 (en) * 2015-10-07 2019-02-28 Remd Biotherapeutics, Inc. Methods For Treating Rare Genetic Disorders Using Glucagon Receptor Antagonistic Antibodies
US20190002577A1 (en) * 2016-01-04 2019-01-03 Remd Biotherapeutics, Inc. Methods Of Treating Type 2 Diabetes Mellitus Using Glucagon Receptor Antagonistic Antibodies
EP3475299A4 (en) * 2016-06-27 2020-03-18 President and Fellows of Harvard College COMPOUNDS USEFUL FOR TREATING METABOLIC DISORDERS
EP3474849A4 (en) * 2016-06-27 2020-07-29 The Broad Institute, Inc. COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF DIABETES
MX2019002437A (es) 2016-08-30 2019-10-09 Regeneron Pharma Metodos para tratar la resistencia severa a la insulina interfiriendo con la señalizacion del receptor de glucagon.
WO2018075792A1 (en) * 2016-10-20 2018-04-26 Regeneron Pharmaceuticals, Inc. Methods of lowering blood glucose levels
WO2018140729A1 (en) * 2017-01-27 2018-08-02 Ngm Biopharmaceuticals, Inc. Glucagon receptor binding proteins and methods of use thereof
CN110357959B (zh) 2018-04-10 2023-02-28 鸿运华宁（杭州）生物医药有限公司 Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
WO2020023847A1 (en) 2018-07-27 2020-01-30 Ngm Biopharmaceuticals, Inc. Use of glucagon receptor antagonists with immunotherapeutic agent
CN115947849A (zh) 2018-12-21 2023-04-11 江苏恒瑞医药股份有限公司 双特异性蛋白
CN110898225A (zh) * 2019-12-23 2020-03-24 黑龙江中医药大学 mTOR/S6K1及MAPK信号通路抑制在胰岛素抵抗改善中的应用
CN113045657B (zh) * 2019-12-26 2022-06-07 杭州济元基因科技有限公司 一种人源化抗人bcma单克隆抗体及其car-t细胞

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Also Published As

Publication number Publication date
US20140335091A1 (en) 2014-11-13
PE20151871A1 (es) 2015-12-24
JP2016520058A (ja) 2016-07-11
PH12015502547A1 (en) 2016-02-22
CN105189560A (zh) 2015-12-23
US20160311912A1 (en) 2016-10-27
KR20160005749A (ko) 2016-01-15
TW201446803A (zh) 2014-12-16
CA2911412A1 (en) 2014-11-13
RU2015147721A (ru) 2017-06-15
TW201702274A (zh) 2017-01-16
WO2014181229A2 (en) 2014-11-13
WO2014181229A3 (en) 2015-04-16
US9248189B2 (en) 2016-02-02
AU2014264295A1 (en) 2015-10-29
EP2994489A2 (en) 2016-03-16
MX2015015339A (es) 2016-07-15
SG11201508264UA (en) 2015-11-27

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