HK1216851A1 - 用於提高細胞存活力的組合物和使用該組合物的方法 - Google Patents

用於提高細胞存活力的組合物和使用該組合物的方法

Info

Publication number
HK1216851A1
HK1216851A1 HK16104836.2A HK16104836A HK1216851A1 HK 1216851 A1 HK1216851 A1 HK 1216851A1 HK 16104836 A HK16104836 A HK 16104836A HK 1216851 A1 HK1216851 A1 HK 1216851A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
cell viability
improving cell
improving
Prior art date
Application number
HK16104836.2A
Other languages
English (en)
Inventor
喬舒亞．
．科恩
賈斯廷．克萊
Original Assignee
Amylyx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51569584&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1216851(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amylyx Pharmaceuticals Inc filed Critical Amylyx Pharmaceuticals Inc
Publication of HK1216851A1 publication Critical patent/HK1216851A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
HK16104836.2A 2013-03-24 2016-04-27 用於提高細胞存活力的組合物和使用該組合物的方法 HK1216851A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361804690P 2013-03-24 2013-03-24
US14/140,083 US9872865B2 (en) 2013-03-24 2013-12-24 Compositions for improving cell viability and methods of use thereof
PCT/US2014/018040 WO2014158547A1 (en) 2013-03-24 2014-02-24 Compositions for improving cell viability and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1216851A1 true HK1216851A1 (zh) 2016-12-09

Family

ID=51569584

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16104836.2A HK1216851A1 (zh) 2013-03-24 2016-04-27 用於提高細胞存活力的組合物和使用該組合物的方法

Country Status (20)

Country Link
US (7) US9872865B2 (zh)
EP (2) EP2978419B1 (zh)
JP (5) JP6495237B2 (zh)
KR (6) KR102607635B1 (zh)
CN (3) CN105050593B (zh)
AU (4) AU2014242123B2 (zh)
CA (1) CA2908683A1 (zh)
CY (1) CY1123092T1 (zh)
DK (1) DK2978419T3 (zh)
ES (1) ES2796250T3 (zh)
HK (1) HK1216851A1 (zh)
HR (1) HRP20200990T1 (zh)
HU (1) HUE051105T2 (zh)
LT (1) LT2978419T (zh)
ME (1) ME03747B (zh)
PL (1) PL2978419T3 (zh)
PT (1) PT2978419T (zh)
RS (1) RS60596B1 (zh)
SI (1) SI2978419T1 (zh)
WO (1) WO2014158547A1 (zh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9872865B2 (en) 2013-03-24 2018-01-23 Amylyx Pharmaceuticals Inc. Compositions for improving cell viability and methods of use thereof
KR20180012858A (ko) * 2015-06-15 2018-02-06 엔엠디 파마 에이피에스 신경근 장애의 치료에 사용하기 위한 화합물
KR101743960B1 (ko) * 2015-07-06 2017-06-08 서울대학교산학협력단 G단백질 결합형 수용체19 작용제를 유효성분으로 함유하는 알츠하이머 질환 또는 치매를 예방, 치료 또는 지연하기 위한 약학적 조성물
WO2017044807A2 (en) * 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
BR112019004540A2 (pt) 2016-09-12 2019-05-28 Hoffman Steven método para tratar demência em um paciente, composição farmacêutica, método para tratar demência em um paciente, método para reduzir a probabilidade de desenvolver demência em um paciente, composição para uso no tratamento de demência em um paciente, composição e composição para uso na redução da probabilidade de desenvolver demência em um paciente submetido a uma terapia longa de um fármaco não-esteroide anti-inflamatório ou aspirina
US20210293794A1 (en) * 2017-02-24 2021-09-23 University Of Hawii Cancer Center Metabolic biomarkers for the identification and characterization of alzheimers disease
US11591284B2 (en) 2017-12-14 2023-02-28 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US11147788B2 (en) 2017-12-14 2021-10-19 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
US11730714B2 (en) 2017-12-14 2023-08-22 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
EA202191683A1 (ru) * 2018-12-18 2021-09-01 Сантен Фармасьютикал Ко., Лтд. Средство, содержащее 4-фенилбутират, для профилактики или лечения пресбиопии
CA3140042A1 (en) 2019-05-14 2020-11-19 Tyme, Inc. Compositions and methods for treating cancer
MX2022007276A (es) * 2019-12-16 2023-04-25 Amylyx Pharmaceuticals Inc Tratamiento de la esclerosis amiotrofica lateral y enfermedades relacionadas.
US11583542B2 (en) * 2019-12-16 2023-02-21 Amylyx Pharmaceuticals, Inc. Compositions of bile acids and phenylbutyrate compounds
CN115103676A (zh) * 2020-02-13 2022-09-23 普瑞尼亚神经治疗有限公司 使用普利多匹定和另一种激活剂治疗肌萎缩侧索的组合疗法
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
WO2022188029A1 (zh) * 2021-03-09 2022-09-15 兆科药业（广州）有限公司 一种含牛磺熊去氧胆酸、苯丁酸钠的复方散剂/颗粒剂、制备方法、用途以及其药物组合物
WO2022191296A1 (ja) * 2021-03-10 2022-09-15 昭和電工マテリアルズ株式会社 培地組成物、細胞培養物の製造方法、及び細胞懸濁物
CN113332267A (zh) * 2021-03-31 2021-09-03 中山大学孙逸仙纪念医院 苯丁酸钠在制备预防或治疗帕金森病的药物中的应用
CN113349300A (zh) * 2021-06-07 2021-09-07 湖南农业大学 4-苯基丁酸在制备猪肠道保健产品中的应用
CA3237768A1 (en) * 2021-11-08 2023-05-11 Amylyx Pharmaceuticals, Inc. Combination of turso and sodium phenyl butyrate for the treatment of neurodegenerative diseases
US20230190709A1 (en) * 2021-12-02 2023-06-22 MarvelBiome, Inc. Methods and uses of microbiome compositions, components, or metabolites for treating vagus nerve associated diseases, disorders, and conditions
US20230277630A1 (en) 2022-03-02 2023-09-07 Amylyx Pharmaceuticals, Inc. Methods and compositions for treating amyotrophic lateral sclerosis
US20230364110A1 (en) 2022-05-12 2023-11-16 Amylyx Pharmaceuticals, Inc. Methods and compositions for treating amyotrophic lateral sclerosis
US20230372263A1 (en) 2022-05-17 2023-11-23 Amylyx Pharmaceuticals, Inc. Methods and compositions for treating amyotrophic lateral sclerosis
WO2024015286A1 (en) * 2022-07-11 2024-01-18 AI Therapeutics, Inc. Apilimod combination therapy
WO2024015281A1 (en) * 2022-07-11 2024-01-18 AI Therapeutics, Inc. Apilimod combination therapy
WO2024054412A1 (en) 2022-09-07 2024-03-14 Amylyx Pharmaceuticals, Inc. Methods and compositions for treating amyotrophic lateral sclerosis
WO2024072778A1 (en) 2022-09-29 2024-04-04 Amylyx Pharmaceuticals, Inc. Methods and compositions for treating amyotrophic lateral sclerosis
WO2024095118A1 (en) 2022-10-31 2024-05-10 Novartis Ag Dosing regimen of a csf-1r inhibitor for use in the treatment of amyotrophic lateral sclerosis

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225031A1 (en) 2002-05-21 2003-12-04 Quay Steven C. Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid
JP2006514097A (ja) 2003-04-02 2006-04-27 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 細胞生育促進方法
CN101048164B (zh) 2004-11-01 2012-05-09 柳署弘 降低肌萎缩性侧索硬化中神经变性的组合物
KR101358078B1 (ko) 2004-11-01 2014-02-06 주식회사 유스팜인터내셔널 근위축성 측삭 경화증의 신경퇴행을 감소시키기 위한 방법및 조성물
US20060135612A1 (en) 2004-12-17 2006-06-22 U.S. Department Of Veterans Affairs Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent
US20080194531A1 (en) 2005-02-10 2008-08-14 Steer Clifford J Methods for Treating Visual Disorders
EP2001484A4 (en) 2006-03-22 2010-04-21 Harvard College METHOD AND COMPOSITIONS FOR TREATING HYPERCHOLESTERINEMIA AND ATHEROSCLEROSIS
US7737175B2 (en) 2007-06-01 2010-06-15 Duke University Methods and compositions for regulating HDAC4 activity
ES2332687B1 (es) 2008-03-13 2011-01-10 Proyecto De Biomedicina Cima, S.L. Nuevos usos de 4pba y sus sales farmaceuticamente aceptables.
CA2723833A1 (en) 2008-05-12 2009-11-19 Umut Ozcan Methods and compositions for the treatment of obesity
US20110142799A1 (en) 2008-06-23 2011-06-16 President And Fellows Of Harvard College Modulation of neurodegenerative disease by modulating xbp-1 activity
WO2010086864A1 (en) 2009-02-02 2010-08-05 Galmed International Ltd. Methods and compositions for treating alzheimer's disease
EP2422787A1 (en) 2010-08-17 2012-02-29 Neurotec Pharma, S.L. Diazoxide for use in the treatment of amyotrophic lateral sclerosis (als)
WO2013067096A2 (en) 2011-11-01 2013-05-10 Metselex, Inc. Prevention or attenuation of neuropathic pain and kidney injury by tauroursodeoxycholic acid
EP2599477A1 (en) 2011-11-30 2013-06-05 Lunamed AG 4-Phenylbutyric acid sustained release formulation
US20150072967A1 (en) 2012-03-20 2015-03-12 Metselex, Inc. Tauroursodeoxycholic acid attentuates or abolishes formation and deposition of amyloid-b peptide
US9872865B2 (en) 2013-03-24 2018-01-23 Amylyx Pharmaceuticals Inc. Compositions for improving cell viability and methods of use thereof
EP3016654B1 (en) 2013-07-01 2018-09-05 Bruschettini S.r.l. Tauroursodeoxycholic acid (tudca) for use in the treatment of neurodegenerative disorders
US10142799B2 (en) 2014-08-19 2018-11-27 Qualcomm Incorporated Multicasting traffic using multi-connectivity

Also Published As

Publication number Publication date
DK2978419T3 (da) 2020-05-04
CA2908683A1 (en) 2014-10-02
AU2019200658B2 (en) 2020-12-24
JP7080944B2 (ja) 2022-06-06
US20200171052A1 (en) 2020-06-04
JP2016515575A (ja) 2016-05-30
US20220110948A1 (en) 2022-04-14
KR102460746B1 (ko) 2022-10-31
CN110787169A (zh) 2020-02-14
US20200230156A1 (en) 2020-07-23
US20140288030A1 (en) 2014-09-25
ES2796250T3 (es) 2020-11-26
EP2978419A1 (en) 2016-02-03
KR102223250B1 (ko) 2021-03-08
HUE051105T2 (hu) 2021-03-01
PL2978419T3 (pl) 2020-10-19
JP2019123721A (ja) 2019-07-25
AU2021201770B2 (en) 2022-05-26
HRP20200990T1 (hr) 2020-10-16
CN110787169B (zh) 2023-10-20
KR20220066178A (ko) 2022-05-23
SI2978419T1 (sl) 2020-11-30
KR20230164242A (ko) 2023-12-01
CN105050593A (zh) 2015-11-11
JP7242945B2 (ja) 2023-03-20
JP2022122929A (ja) 2022-08-23
CN105050593B (zh) 2019-12-03
JP6766198B2 (ja) 2020-10-07
AU2014242123A1 (en) 2015-09-17
CY1123092T1 (el) 2021-10-29
CN109999043A (zh) 2019-07-12
KR102607635B1 (ko) 2023-11-30
EP2978419B1 (en) 2020-04-15
AU2022221410A1 (en) 2022-09-15
LT2978419T (lt) 2020-08-10
CN109999043B (zh) 2023-01-20
KR20210156312A (ko) 2021-12-24
KR20220148337A (ko) 2022-11-04
AU2014242123B2 (en) 2018-11-01
JP6495237B2 (ja) 2019-04-03
KR20210025134A (ko) 2021-03-08
EP3750531A1 (en) 2020-12-16
JP2023085274A (ja) 2023-06-20
ME03747B (me) 2021-04-20
KR20150135471A (ko) 2015-12-02
WO2014158547A1 (en) 2014-10-02
EP2978419A4 (en) 2016-11-16
US20220160733A1 (en) 2022-05-26
AU2021201770A1 (en) 2021-04-15
RS60596B1 (sr) 2020-08-31
US11071742B2 (en) 2021-07-27
US10857162B2 (en) 2020-12-08
PT2978419T (pt) 2020-06-19
KR102396714B1 (ko) 2022-05-12
US10251896B2 (en) 2019-04-09
US20180098999A1 (en) 2018-04-12
AU2019200658A1 (en) 2019-02-21
JP2021008473A (ja) 2021-01-28
US20190255072A1 (en) 2019-08-22
US9872865B2 (en) 2018-01-23

Similar Documents

Publication Publication Date Title
HK1216851A1 (zh) 用於提高細胞存活力的組合物和使用該組合物的方法
HK1219975A1 (zh) 用於病毒生產的細胞系和使用方法
HK1221978A1 (zh) 組合物及其使用方法
HK1210494A1 (zh) 用於細胞培養的裝置和方法
EP2834322A4 (en) BIOCHARBON COMPOSITIONS AND METHODS OF USE
IL244296A0 (en) Cell-permeable conjugates and methods of using them
EP2968549A4 (en) CELL CULTURE METHODS
EP2836224A4 (en) COMPOSITIONS OF BIOZOOSE AND RELATED METHODS
EP2971014A4 (en) CELL CULTURE METHODS
EP2971040A4 (en) CELL CULTURE METHODS
EP2964235A4 (en) ANTIMICROBIAL-ANTIBIOFILM COMPOSITIONS AND METHODS OF USE
EP2912178A4 (en) SUPER AMPLIFIER AND METHOD FOR USE THEREOF
GB201200458D0 (en) Methods of preparing cells and compositions
EP2968244A4 (en) COMPOSITIONS AND METHODS FOR USING ALIGAL COMPOUNDS
IL239631A0 (en) Anti-integrin cell 1 antibody preparations and methods of using them
IL245272A0 (en) pif-transfected cells and methods of use
EP2906041A4 (en) COMPOSITIONS AND METHODS OF USING INAPPETENCE COMPOUND
IL233961A0 (en) The composition of a phytogenic supplement and methods of its use
HK1210436A1 (zh) 新型細胞組合物和方法
EP2971002A4 (en) CELL CELL EXPRESSION CASSETTE COMPOSITIONS AND METHODS OF USE
HK1219292A1 (zh) +細胞組合物及其使用方法
GB201307377D0 (en) Devices and methods for culture of cells
EP2841164A4 (en) COMPOSITIONS AND USE PROCEDURES FOR THE SKIN
GB201310349D0 (en) Composition and method of use thereof
GB201301928D0 (en) Composition and method of use thereof