HK1216432A1 - 製備 -二氧戊環核苷的方法 - Google Patents
製備 -二氧戊環核苷的方法Info
- Publication number
- HK1216432A1 HK1216432A1 HK16104317.0A HK16104317A HK1216432A1 HK 1216432 A1 HK1216432 A1 HK 1216432A1 HK 16104317 A HK16104317 A HK 16104317A HK 1216432 A1 HK1216432 A1 HK 1216432A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- manufacture
- methods
- dioxolane nucleosides
- nucleosides
- dioxolane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54154504P | 2004-02-03 | 2004-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1216432A1 true HK1216432A1 (zh) | 2016-11-11 |
Family
ID=34837503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16104317.0A HK1216432A1 (zh) | 2004-02-03 | 2016-04-15 | 製備 -二氧戊環核苷的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7785839B2 (zh) |
| EP (1) | EP1720840B1 (zh) |
| KR (1) | KR101157468B1 (zh) |
| CN (2) | CN105039489A (zh) |
| BR (1) | BRPI0507363A (zh) |
| CA (1) | CA2554782C (zh) |
| ES (1) | ES2568467T3 (zh) |
| HK (1) | HK1216432A1 (zh) |
| WO (1) | WO2005074654A2 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1467990B1 (en) * | 2002-01-25 | 2012-03-07 | Shire BioChem Inc. | Process for producing dioxolane nucleoside analogue precursors |
| ES2568467T3 (es) * | 2004-02-03 | 2016-04-29 | Emory University | Métodos para la fabricación de nucleósidos de 1,3-dioxolano |
| CN105385621B (zh) * | 2015-11-20 | 2018-10-02 | 浙江昌明药业有限公司 | 琼氏不动杆菌zjutfet-1及其应用 |
| WO2019245444A1 (en) | 2018-06-21 | 2019-12-26 | Medivir Ab | Base-modified cytidine nucleotides for leukemia therapy |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684164A (en) | 1988-04-11 | 1997-11-04 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
| NZ228645A (en) | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
| US5041449A (en) | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
| US5270315A (en) | 1988-04-11 | 1993-12-14 | Biochem Pharma Inc. | 4-(purinyl bases)-substituted-1,3-dioxlanes |
| US6069252A (en) * | 1990-02-01 | 2000-05-30 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers |
| US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| US6642245B1 (en) * | 1990-02-01 | 2003-11-04 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
| US5700937A (en) * | 1990-02-01 | 1997-12-23 | Emory University | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
| US5276151A (en) | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| US6703396B1 (en) * | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
| US5179104A (en) | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
| US5444063A (en) | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
| US5925643A (en) | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
| ZA923640B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9311709D0 (en) | 1993-06-07 | 1993-07-21 | Iaf Biochem Int | Stereoselective synthesis of nucleoside analogues using bicycle intermediate |
| JP3524606B2 (ja) * | 1994-12-28 | 2004-05-10 | 三洋電機株式会社 | 固形製剤充填装置 |
| GB9525606D0 (en) | 1995-12-14 | 1996-02-14 | Iaf Biochem Int | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
| US5792773A (en) | 1996-11-15 | 1998-08-11 | Yale University | L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection |
| DE69823984T2 (de) * | 1997-03-19 | 2005-05-12 | University Of Georgia Research Foundation, Inc. | Synthese, anti-hiv- und anti-hepatitis-b-virus-aktivitäten von 1,3-oxaselenolannukleosiden |
| RU2244712C2 (ru) | 1998-08-12 | 2005-01-20 | Гайлид Сайенсиз, Инк. | Способ получения 1,3-оксатиоланового нуклеозида, способ получения производного 1,3-оксатиоланил-5-она |
| AP2001002207A0 (en) | 1998-12-23 | 2001-09-30 | Shire Biochem Inc | Antiviral nucleoside analogues. |
| JP2002538780A (ja) | 1999-02-11 | 2002-11-19 | シェア バイオケム インコーポレーテッド | ヌクレオシド類似体の立体選択的合成 |
| US6512845B1 (en) * | 1999-07-20 | 2003-01-28 | Canon Kabushiki Kaisha | Iterative approximation of color patch area |
| AU3144801A (en) | 2000-02-11 | 2001-08-20 | Shire Biochem Inc. | Stereoselective synthesis of nucleoside analogues |
| MXPA03003278A (es) * | 2000-10-13 | 2005-07-01 | Shire Biochem Inc | Analogos de dioxolano para suministro intercelular mejorado. |
| EP1467990B1 (en) | 2002-01-25 | 2012-03-07 | Shire BioChem Inc. | Process for producing dioxolane nucleoside analogue precursors |
| IL166682A0 (en) | 2002-08-06 | 2006-01-15 | Pharmasset Ltd | Processes for preparing 1,3-dioxolane nucleosides |
| ES2568467T3 (es) * | 2004-02-03 | 2016-04-29 | Emory University | Métodos para la fabricación de nucleósidos de 1,3-dioxolano |
-
2005
- 2005-02-03 ES ES05722747.2T patent/ES2568467T3/es active Active
- 2005-02-03 KR KR1020067017856A patent/KR101157468B1/ko active IP Right Grant
- 2005-02-03 WO PCT/US2005/003620 patent/WO2005074654A2/en active Application Filing
- 2005-02-03 BR BRPI0507363-4A patent/BRPI0507363A/pt active Search and Examination
- 2005-02-03 CN CN201510291744.8A patent/CN105039489A/zh active Pending
- 2005-02-03 CN CNA2005800119950A patent/CN101044122A/zh active Pending
- 2005-02-03 US US11/051,287 patent/US7785839B2/en active Active
- 2005-02-03 EP EP05722747.2A patent/EP1720840B1/en active Active
- 2005-02-03 CA CA2554782A patent/CA2554782C/en not_active Expired - Fee Related
-
2010
- 2010-08-27 US US12/870,319 patent/US8420354B2/en active Active
-
2016
- 2016-04-15 HK HK16104317.0A patent/HK1216432A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1720840A4 (en) | 2009-01-21 |
| CN101044122A (zh) | 2007-09-26 |
| CA2554782C (en) | 2013-08-13 |
| WO2005074654A3 (en) | 2005-09-22 |
| US20110130559A1 (en) | 2011-06-02 |
| EP1720840B1 (en) | 2016-02-03 |
| ES2568467T3 (es) | 2016-04-29 |
| US8420354B2 (en) | 2013-04-16 |
| KR20070085075A (ko) | 2007-08-27 |
| US7785839B2 (en) | 2010-08-31 |
| CN105039489A (zh) | 2015-11-11 |
| KR101157468B1 (ko) | 2012-07-06 |
| EP1720840A2 (en) | 2006-11-15 |
| US20060036092A1 (en) | 2006-02-16 |
| CA2554782A1 (en) | 2005-08-18 |
| WO2005074654A2 (en) | 2005-08-18 |
| BRPI0507363A (pt) | 2007-07-03 |
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