HK1215566A1 - 抗新生血管的化合物、其中間體及其用途 - Google Patents
抗新生血管的化合物、其中間體及其用途Info
- Publication number
- HK1215566A1 HK1215566A1 HK16103268.1A HK16103268A HK1215566A1 HK 1215566 A1 HK1215566 A1 HK 1215566A1 HK 16103268 A HK16103268 A HK 16103268A HK 1215566 A1 HK1215566 A1 HK 1215566A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- angiogenesis compound
- angiogenesis
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310122138 | 2013-04-09 | ||
PCT/CN2014/074977 WO2014166386A1 (zh) | 2013-04-09 | 2014-04-09 | 抗新生血管的化合物、其中间体及其用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1215566A1 true HK1215566A1 (zh) | 2016-09-02 |
Family
ID=51688942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16103268.1A HK1215566A1 (zh) | 2013-04-09 | 2016-03-21 | 抗新生血管的化合物、其中間體及其用途 |
Country Status (12)
Country | Link |
---|---|
US (2) | US9540381B2 (zh) |
EP (1) | EP2985283B1 (zh) |
JP (1) | JP6152921B2 (zh) |
KR (1) | KR101854203B1 (zh) |
CN (2) | CN104334543B (zh) |
AU (1) | AU2014252584B2 (zh) |
CA (1) | CA2908849C (zh) |
ES (1) | ES2899726T3 (zh) |
HK (1) | HK1215566A1 (zh) |
NZ (1) | NZ713187A (zh) |
SG (1) | SG11201508330WA (zh) |
WO (1) | WO2014166386A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101854203B1 (ko) | 2013-04-09 | 2018-06-20 | 광저우 후이 보 루이 바이오로지컬 파마슈티컬 테크놀로지 코., 엘티디. | 신생혈관형성 억제 화합물, 그의 중간체 및 용도 |
JP7008064B2 (ja) * | 2016-05-27 | 2022-01-25 | 杭州英創医薬科技有限公司 | Fgfr4阻害剤としてのヘテロ環式化合物 |
CN107812006A (zh) * | 2017-11-13 | 2018-03-20 | 全椒先奇医药科技有限公司 | 一种治疗急性肾衰药物组合物及其应用 |
US20230301904A1 (en) * | 2020-04-24 | 2023-09-28 | Guangzhou Kangrui Biological Pharmaceutical Technology Co., Ltd. | Formulation for Treating Ophthalmic Conditions |
CN111743885B (zh) * | 2020-08-17 | 2022-03-15 | 山东省科学院生物研究所 | 一种对羟基苯乙酸在预防和/或治疗心血管疾病中的应用 |
CN112194598B (zh) * | 2020-10-15 | 2021-12-21 | 郑州猫眼农业科技有限公司 | 3-(叔丁氧基羰基-r氧基羰基甲基-氨基)-丙酸酯的制备方法 |
WO2023143611A1 (zh) * | 2022-01-30 | 2023-08-03 | 兰泰克生物技术公司 | 一种治疗癌症的方法 |
CN114634421A (zh) * | 2022-02-24 | 2022-06-17 | 济宁晟泰药业有限公司 | 一种达沙替尼中间体的制备方法 |
CN117164580A (zh) * | 2022-05-27 | 2023-12-05 | 苏州泽璟生物制药股份有限公司 | 一种kras g12c抑制剂的制备方法及其中间体 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4757743A (en) * | 1987-04-29 | 1988-07-19 | Vickers, Incorporated | Power transmission |
CZ303692B6 (cs) | 1999-02-10 | 2013-03-13 | Astrazeneca Ab | Chinazolinové deriváty jako inhibitory angiogeneze |
CA2553423C (en) * | 2004-01-23 | 2012-03-20 | Amgen Inc. | Heterocyclic compounds for use in the treatment of cancer and the inhibition of angiogenesis |
DE102005016634A1 (de) * | 2005-04-12 | 2006-10-19 | Merck Patent Gmbh | Neuartige Aza-Hetercyclen als Kinase-Inhibitoren |
GT200600411A (es) * | 2005-09-13 | 2007-05-21 | Novartis Ag | Combinaciones que comprenden un inhibidor del receptor del factor de crecimiento endotelial vascular |
US8110687B2 (en) * | 2005-12-08 | 2012-02-07 | Millennium Pharmaceuticals, Inc. | Bicyclic compounds with kinase inhibitory activity |
GB0604937D0 (en) * | 2006-03-10 | 2006-04-19 | Novartis Ag | Organic compounds |
GB0605120D0 (en) * | 2006-03-14 | 2006-04-26 | Novartis Ag | Organic Compounds |
JP2009537632A (ja) * | 2006-05-19 | 2009-10-29 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 過剰増殖性障害および血管新生障害の処置に有用なピリドンカルボキサミド誘導体 |
CN106146473B (zh) * | 2013-03-28 | 2020-04-14 | 宁波市方昌医药有限公司 | 一种抗血管新生化合物 |
KR101854203B1 (ko) | 2013-04-09 | 2018-06-20 | 광저우 후이 보 루이 바이오로지컬 파마슈티컬 테크놀로지 코., 엘티디. | 신생혈관형성 억제 화합물, 그의 중간체 및 용도 |
-
2014
- 2014-04-09 KR KR1020157032078A patent/KR101854203B1/ko active IP Right Grant
- 2014-04-09 SG SG11201508330WA patent/SG11201508330WA/en unknown
- 2014-04-09 CN CN201480000555.4A patent/CN104334543B/zh active Active
- 2014-04-09 JP JP2016506767A patent/JP6152921B2/ja active Active
- 2014-04-09 WO PCT/CN2014/074977 patent/WO2014166386A1/zh active Application Filing
- 2014-04-09 CN CN201710702483.3A patent/CN107245071A/zh active Pending
- 2014-04-09 NZ NZ713187A patent/NZ713187A/en unknown
- 2014-04-09 EP EP14782609.3A patent/EP2985283B1/en active Active
- 2014-04-09 US US14/392,101 patent/US9540381B2/en active Active
- 2014-04-09 CA CA2908849A patent/CA2908849C/en active Active
- 2014-04-09 ES ES14782609T patent/ES2899726T3/es active Active
- 2014-04-09 AU AU2014252584A patent/AU2014252584B2/en active Active
-
2016
- 2016-03-21 HK HK16103268.1A patent/HK1215566A1/zh unknown
- 2016-10-20 US US15/298,545 patent/US10064864B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2014166386A1 (zh) | 2014-10-16 |
US9540381B2 (en) | 2017-01-10 |
EP2985283B1 (en) | 2021-10-06 |
JP6152921B2 (ja) | 2017-06-28 |
CA2908849A1 (en) | 2014-10-16 |
ES2899726T3 (es) | 2022-03-14 |
US20160075708A1 (en) | 2016-03-17 |
NZ713187A (en) | 2017-04-28 |
EP2985283A1 (en) | 2016-02-17 |
CN104334543B (zh) | 2017-08-25 |
KR20150139962A (ko) | 2015-12-14 |
AU2014252584B2 (en) | 2016-10-13 |
AU2014252584A8 (en) | 2015-11-12 |
EP2985283A4 (en) | 2016-09-14 |
JP2016515636A (ja) | 2016-05-30 |
CN107245071A (zh) | 2017-10-13 |
KR101854203B1 (ko) | 2018-06-20 |
SG11201508330WA (en) | 2015-11-27 |
CA2908849C (en) | 2017-11-07 |
AU2014252584A1 (en) | 2015-11-05 |
CN104334543A (zh) | 2015-02-04 |
US20170119768A1 (en) | 2017-05-04 |
US10064864B2 (en) | 2018-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHRG | Changes in the register |
Free format text: CORRECTION OF THE NAME OF THE INVENTOR: FROM LUO, HONGRONG |