HK1213001A1 - 與肝細胞生長因子結合的設計錨蛋白重複蛋白 - Google Patents
與肝細胞生長因子結合的設計錨蛋白重複蛋白Info
- Publication number
- HK1213001A1 HK1213001A1 HK16100966.2A HK16100966A HK1213001A1 HK 1213001 A1 HK1213001 A1 HK 1213001A1 HK 16100966 A HK16100966 A HK 16100966A HK 1213001 A1 HK1213001 A1 HK 1213001A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- growth factor
- hepatocyte growth
- ankyrin repeat
- repeat proteins
- designed ankyrin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13170056 | 2013-05-31 | ||
PCT/EP2014/061368 WO2014191574A1 (en) | 2013-05-31 | 2014-06-02 | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1213001A1 true HK1213001A1 (zh) | 2016-06-24 |
Family
ID=48536726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16100966.2A HK1213001A1 (zh) | 2013-05-31 | 2016-01-28 | 與肝細胞生長因子結合的設計錨蛋白重複蛋白 |
Country Status (6)
Country | Link |
---|---|
US (1) | US11453708B2 (zh) |
EP (1) | EP3004152B1 (zh) |
JP (1) | JP6486908B2 (zh) |
CN (1) | CN105209483B (zh) |
HK (1) | HK1213001A1 (zh) |
WO (1) | WO2014191574A1 (zh) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
WO2016023898A2 (en) * | 2014-08-11 | 2016-02-18 | Medimmune Limited | Intracellular antigen binding |
ES2953482T3 (es) * | 2015-04-02 | 2023-11-13 | Molecular Partners Ag | Dominios de repetición de anquirina diseñados con especificidad de unión para la albúmina sérica |
NZ751689A (en) | 2016-09-22 | 2021-07-30 | Molecular Partners Ag | Recombinant binding proteins and their use |
JP7380999B2 (ja) * | 2018-09-06 | 2023-11-15 | 国立大学法人 東京大学 | 環状ペプチド |
GB201902392D0 (en) * | 2019-02-21 | 2019-04-10 | Cambridge Entpr Ltd | Modular binding proteins |
UY38739A (es) | 2019-06-04 | 2020-12-31 | Molecular Partners Ag | Proteínas multiespecíficas |
US20220298212A1 (en) * | 2019-06-04 | 2022-09-22 | Molecular Partners Ag | Recombinant 4-1bb binding proteins and their use |
WO2020245173A1 (en) * | 2019-06-04 | 2020-12-10 | Molecular Partners Ag | Recombinant fap binding proteins and their use |
KR20220113491A (ko) | 2019-12-11 | 2022-08-12 | 몰리큘라 파트너스 아게 | 재조합 펩티드-mhc 복합체 결합 단백질 및 이의 생성 및 용도 |
TW202208404A (zh) | 2020-05-06 | 2022-03-01 | 瑞士商分子組合公司 | 新穎錨蛋白重複結合蛋白質及其用途 |
AU2021271129A1 (en) | 2020-05-14 | 2022-12-15 | Molecular Partners Ag | Multispecific proteins |
WO2021229076A1 (en) * | 2020-05-14 | 2021-11-18 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
US11981710B2 (en) | 2020-08-18 | 2024-05-14 | Athebio Ag | N-terminal capping modules of ankyrin repeat domains |
EP3957649A1 (en) * | 2020-08-18 | 2022-02-23 | Athebio AG | Improved n-terminal capping modules of ankyrin repeat domains |
WO2022061240A1 (en) * | 2020-09-21 | 2022-03-24 | The Board Of Trustees Of The Leland Stanford Junior University | Heteromultimeric proteins for reducing ige-dependent allergic effector cell activation |
JP2023554351A (ja) | 2020-12-16 | 2023-12-27 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規の徐放性プロドラッグ |
BR112023018293A2 (pt) | 2021-03-09 | 2023-10-31 | Molecular Partners Ag | Acopladores de célula t multiespecíficos à base de darpin |
JP2024509890A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | プロテアーゼ切断可能なプロドラッグ |
JP2024508969A (ja) | 2021-03-09 | 2024-02-28 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規のDARPinに基づくCD33エンゲージャ |
AU2022233791A1 (en) | 2021-03-09 | 2023-09-28 | Molecular Partners Ag | Novel darpin based cd123 engagers |
WO2022219185A1 (en) * | 2021-04-16 | 2022-10-20 | Athebio Ag | N-terminal capping modules of ankyrin repeat domains |
CN118354784A (zh) | 2021-12-14 | 2024-07-16 | 分子合作伙伴股份公司 | 具有双重结合特异性的经设计的重复结构域及其用途 |
WO2024028278A1 (en) | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5291279B2 (ja) | 2000-09-08 | 2013-09-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
PL1863519T3 (pl) | 2005-03-31 | 2014-03-31 | Massachusetts Gen Hospital | Modulowanie aktywności HGF/HGFR do leczenia obrzęku wskutek niedrożności naczyń chłonnych |
US8846577B2 (en) | 2005-07-08 | 2014-09-30 | University Of Zurich | Phage display using cotranslational translocation of fusion polypeptides |
US9365629B2 (en) | 2007-09-24 | 2016-06-14 | University Of Zurich | Designed armadillo repeat proteins |
CN107011425B (zh) | 2008-11-03 | 2021-01-01 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
UY32663A (es) | 2009-05-28 | 2010-12-31 | Glaxo Group Ltd | Proteinas de union a antigeno |
TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
SG190362A1 (en) * | 2010-11-24 | 2013-06-28 | Glaxo Group Ltd | Multispecific antigen binding proteins targeting hgf |
DK2643349T3 (da) | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
CN104105704A (zh) * | 2011-04-29 | 2014-10-15 | 詹森生物科技公司 | Il4/il13结合重复蛋白及用途 |
RU2014150224A (ru) | 2012-06-28 | 2016-08-20 | Молекьюлар Партнерс Аг | Сконструированный белок с анкириновым повтором, связывающийся с фактором роста тромбоцитов |
EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
-
2014
- 2014-06-02 EP EP14727816.2A patent/EP3004152B1/en active Active
- 2014-06-02 CN CN201480028078.2A patent/CN105209483B/zh active Active
- 2014-06-02 JP JP2016516198A patent/JP6486908B2/ja active Active
- 2014-06-02 US US14/891,792 patent/US11453708B2/en active Active
- 2014-06-02 WO PCT/EP2014/061368 patent/WO2014191574A1/en active Application Filing
-
2016
- 2016-01-28 HK HK16100966.2A patent/HK1213001A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2016521688A (ja) | 2016-07-25 |
US20160251404A1 (en) | 2016-09-01 |
US11453708B2 (en) | 2022-09-27 |
JP6486908B2 (ja) | 2019-03-20 |
EP3004152A1 (en) | 2016-04-13 |
CN105209483B (zh) | 2021-07-27 |
EP3004152B1 (en) | 2020-09-30 |
WO2014191574A1 (en) | 2014-12-04 |
CN105209483A (zh) | 2015-12-30 |
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