HK1213001A1 - 與肝細胞生長因子結合的設計錨蛋白重複蛋白 - Google Patents

與肝細胞生長因子結合的設計錨蛋白重複蛋白

Info

Publication number
HK1213001A1
HK1213001A1 HK16100966.2A HK16100966A HK1213001A1 HK 1213001 A1 HK1213001 A1 HK 1213001A1 HK 16100966 A HK16100966 A HK 16100966A HK 1213001 A1 HK1213001 A1 HK 1213001A1
Authority
HK
Hong Kong
Prior art keywords
growth factor
hepatocyte growth
ankyrin repeat
repeat proteins
designed ankyrin
Prior art date
Application number
HK16100966.2A
Other languages
English (en)
Inventor
加比‧特裡西
塔利莎‧巴克
道格拉斯‧菲力浦斯
弗雷德‧
‧默茨
卡什帕‧
‧賓茨
Original Assignee
Molecular Partners Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Partners Ag filed Critical Molecular Partners Ag
Publication of HK1213001A1 publication Critical patent/HK1213001A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16100966.2A 2013-05-31 2016-01-28 與肝細胞生長因子結合的設計錨蛋白重複蛋白 HK1213001A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13170056 2013-05-31
PCT/EP2014/061368 WO2014191574A1 (en) 2013-05-31 2014-06-02 Designed ankyrin repeat proteins binding to hepatocyte growth factor

Publications (1)

Publication Number Publication Date
HK1213001A1 true HK1213001A1 (zh) 2016-06-24

Family

ID=48536726

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16100966.2A HK1213001A1 (zh) 2013-05-31 2016-01-28 與肝細胞生長因子結合的設計錨蛋白重複蛋白

Country Status (6)

Country Link
US (1) US11453708B2 (zh)
EP (1) EP3004152B1 (zh)
JP (1) JP6486908B2 (zh)
CN (1) CN105209483B (zh)
HK (1) HK1213001A1 (zh)
WO (1) WO2014191574A1 (zh)

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TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
WO2016023898A2 (en) * 2014-08-11 2016-02-18 Medimmune Limited Intracellular antigen binding
ES2953482T3 (es) * 2015-04-02 2023-11-13 Molecular Partners Ag Dominios de repetición de anquirina diseñados con especificidad de unión para la albúmina sérica
NZ751689A (en) 2016-09-22 2021-07-30 Molecular Partners Ag Recombinant binding proteins and their use
JP7380999B2 (ja) * 2018-09-06 2023-11-15 国立大学法人 東京大学 環状ペプチド
GB201902392D0 (en) * 2019-02-21 2019-04-10 Cambridge Entpr Ltd Modular binding proteins
UY38739A (es) 2019-06-04 2020-12-31 Molecular Partners Ag Proteínas multiespecíficas
US20220298212A1 (en) * 2019-06-04 2022-09-22 Molecular Partners Ag Recombinant 4-1bb binding proteins and their use
WO2020245173A1 (en) * 2019-06-04 2020-12-10 Molecular Partners Ag Recombinant fap binding proteins and their use
KR20220113491A (ko) 2019-12-11 2022-08-12 몰리큘라 파트너스 아게 재조합 펩티드-mhc 복합체 결합 단백질 및 이의 생성 및 용도
TW202208404A (zh) 2020-05-06 2022-03-01 瑞士商分子組合公司 新穎錨蛋白重複結合蛋白質及其用途
AU2021271129A1 (en) 2020-05-14 2022-12-15 Molecular Partners Ag Multispecific proteins
WO2021229076A1 (en) * 2020-05-14 2021-11-18 Molecular Partners Ag Recombinant cd40 binding proteins and their use
US11981710B2 (en) 2020-08-18 2024-05-14 Athebio Ag N-terminal capping modules of ankyrin repeat domains
EP3957649A1 (en) * 2020-08-18 2022-02-23 Athebio AG Improved n-terminal capping modules of ankyrin repeat domains
WO2022061240A1 (en) * 2020-09-21 2022-03-24 The Board Of Trustees Of The Leland Stanford Junior University Heteromultimeric proteins for reducing ige-dependent allergic effector cell activation
JP2023554351A (ja) 2020-12-16 2023-12-27 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規の徐放性プロドラッグ
BR112023018293A2 (pt) 2021-03-09 2023-10-31 Molecular Partners Ag Acopladores de célula t multiespecíficos à base de darpin
JP2024509890A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト プロテアーゼ切断可能なプロドラッグ
JP2024508969A (ja) 2021-03-09 2024-02-28 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規のＤＡＲＰｉｎに基づくＣＤ３３エンゲージャ
AU2022233791A1 (en) 2021-03-09 2023-09-28 Molecular Partners Ag Novel darpin based cd123 engagers
WO2022219185A1 (en) * 2021-04-16 2022-10-20 Athebio Ag N-terminal capping modules of ankyrin repeat domains
CN118354784A (zh) 2021-12-14 2024-07-16 分子合作伙伴股份公司 具有双重结合特异性的经设计的重复结构域及其用途
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs

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Publication number Priority date Publication date Assignee Title
JP5291279B2 (ja) 2000-09-08 2013-09-18 ウニヴェルジテート・チューリッヒ 反復モジュールを含む反復タンパク質の集合体
PL1863519T3 (pl) 2005-03-31 2014-03-31 Massachusetts Gen Hospital Modulowanie aktywności HGF/HGFR do leczenia obrzęku wskutek niedrożności naczyń chłonnych
US8846577B2 (en) 2005-07-08 2014-09-30 University Of Zurich Phage display using cotranslational translocation of fusion polypeptides
US9365629B2 (en) 2007-09-24 2016-06-14 University Of Zurich Designed armadillo repeat proteins
CN107011425B (zh) 2008-11-03 2021-01-01 分子组合公司 抑制vegf-a受体相互作用的结合蛋白
UY32663A (es) 2009-05-28 2010-12-31 Glaxo Group Ltd Proteinas de union a antigeno
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
SG190362A1 (en) * 2010-11-24 2013-06-28 Glaxo Group Ltd Multispecific antigen binding proteins targeting hgf
DK2643349T3 (da) 2010-11-26 2019-11-25 Molecular Partners Ag Designede repeat-proteiner, der binder til serumalbumin
CN104105704A (zh) * 2011-04-29 2014-10-15 詹森生物科技公司 Il4/il13结合重复蛋白及用途
RU2014150224A (ru) 2012-06-28 2016-08-20 Молекьюлар Партнерс Аг Сконструированный белок с анкириновым повтором, связывающийся с фактором роста тромбоцитов
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.

Also Published As

Publication number Publication date
JP2016521688A (ja) 2016-07-25
US20160251404A1 (en) 2016-09-01
US11453708B2 (en) 2022-09-27
JP6486908B2 (ja) 2019-03-20
EP3004152A1 (en) 2016-04-13
CN105209483B (zh) 2021-07-27
EP3004152B1 (en) 2020-09-30
WO2014191574A1 (en) 2014-12-04
CN105209483A (zh) 2015-12-30

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