HK1211927A1 - Aggrecanase inhibitors - Google Patents

Aggrecanase inhibitors

Info

Publication number
HK1211927A1
HK1211927A1 HK15112729.6A HK15112729A HK1211927A1 HK 1211927 A1 HK1211927 A1 HK 1211927A1 HK 15112729 A HK15112729 A HK 15112729A HK 1211927 A1 HK1211927 A1 HK 1211927A1
Authority
HK
Hong Kong
Prior art keywords
aggrecanase inhibitors
aggrecanase
inhibitors
Prior art date
Application number
HK15112729.6A
Other languages
English (en)
Chinese (zh)
Inventor
Timothy Barrett Durham
Jothirajah Marimuthu
Michael Robert Wiley
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1211927A1 publication Critical patent/HK1211927A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/417Imidazole-alkylamines, e.g. histamine, phentolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15112729.6A 2012-10-26 2015-12-28 Aggrecanase inhibitors HK1211927A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261718965P 2012-10-26 2012-10-26
PCT/US2013/065591 WO2014066151A1 (en) 2012-10-26 2013-10-18 Aggrecanase inhibitors

Publications (1)

Publication Number Publication Date
HK1211927A1 true HK1211927A1 (en) 2016-06-03

Family

ID=49515523

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15112729.6A HK1211927A1 (en) 2012-10-26 2015-12-28 Aggrecanase inhibitors

Country Status (20)

Country Link
US (1) US9206139B2 (pt)
EP (1) EP2912021B1 (pt)
JP (1) JP6251279B2 (pt)
KR (1) KR101689983B1 (pt)
CN (1) CN104755464B (pt)
AR (1) AR092971A1 (pt)
AU (1) AU2013334989B2 (pt)
BR (1) BR112015009032B1 (pt)
CA (1) CA2886526C (pt)
DK (1) DK2912021T3 (pt)
EA (1) EA026037B1 (pt)
ES (1) ES2645970T3 (pt)
HK (1) HK1211927A1 (pt)
HU (1) HUE034616T2 (pt)
MX (1) MX364207B (pt)
NZ (1) NZ706772A (pt)
PL (1) PL2912021T3 (pt)
PT (1) PT2912021T (pt)
TW (1) TWI620738B (pt)
WO (1) WO2014066151A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA123036C2 (uk) 2014-10-16 2021-02-03 Монсанто Текнолоджі Ллс Сконструйований інсектицидний білок, який має активність проти лускокрилих
JO3501B1 (ar) * 2014-12-22 2020-07-05 Servier Lab مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام)
GB201610056D0 (en) * 2016-06-09 2016-07-27 Galapagos Nv And Laboratoires Servier Les Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis
GB201610055D0 (en) 2016-06-09 2016-07-27 Galapagos Nv And Laboratoires Servier Les Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis
WO2021011720A2 (en) * 2019-07-18 2021-01-21 Avidence Therapeutics, Inc. Anti-osteoarthritis compounds and related compositions and methods
EP3822265A1 (en) 2019-11-15 2021-05-19 Bayer AG Substituted hydantoinamides as adamts7 antagonists
EP3822268A1 (en) 2019-11-15 2021-05-19 Bayer Aktiengesellschaft Substituted hydantoinamides as adamts7 antagonists
WO2021214637A1 (en) * 2020-04-20 2021-10-28 St. Jude Children's Research Hospital Composition and methods for treating respiratory diseases
CN115720578A (zh) * 2020-07-09 2023-02-28 深圳信立泰药业股份有限公司 并三环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60234028D1 (de) * 2001-05-25 2009-11-26 Bristol Myers Squibb Co Hydantion-derivate als hemmer von matrix-metalloproteinasen
SE0202539D0 (sv) * 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
US7799795B2 (en) * 2005-06-27 2010-09-21 Amgen Inc. Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders
PE20070505A1 (es) * 2005-07-11 2007-05-15 Wyeth Corp Inhibidores de glutamato de metaloproteinasas de matriz y agrecanasas
PE20071240A1 (es) * 2006-01-17 2008-01-14 Schering Corp Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
US9206139B2 (en) 2015-12-08
EA201590621A1 (ru) 2015-07-30
MX364207B (es) 2019-04-16
JP6251279B2 (ja) 2017-12-20
ES2645970T3 (es) 2017-12-11
KR101689983B1 (ko) 2016-12-26
DK2912021T3 (en) 2017-10-02
BR112015009032A2 (pt) 2017-07-04
AU2013334989A1 (en) 2015-04-23
TW201427955A (zh) 2014-07-16
EP2912021A1 (en) 2015-09-02
CN104755464B (zh) 2017-03-29
CA2886526A1 (en) 2014-05-01
CN104755464A (zh) 2015-07-01
HUE034616T2 (en) 2018-02-28
WO2014066151A1 (en) 2014-05-01
EP2912021B1 (en) 2017-08-16
BR112015009032B1 (pt) 2022-06-28
CA2886526C (en) 2018-03-27
KR20150058480A (ko) 2015-05-28
PL2912021T3 (pl) 2018-01-31
US20150218107A1 (en) 2015-08-06
AR092971A1 (es) 2015-05-06
NZ706772A (en) 2018-05-25
MX2015005297A (es) 2015-07-17
PT2912021T (pt) 2017-11-14
EA026037B1 (ru) 2017-02-28
TWI620738B (zh) 2018-04-11
AU2013334989B2 (en) 2016-02-18
JP2015535248A (ja) 2015-12-10

Similar Documents

Publication Publication Date Title
HRP20181862T1 (hr) Inhibitori dna-pk
IL255206A0 (en) Inhibitors of neprilysin
HK1210775A1 (en) Imidazotriazinecarbonitriles useful as kinase inhibitors
HK1208442A1 (en) Substituted pyrrolopyrimidinylamino-benzothiazolones as mknk kinase inhibitors mknk
ZA201503041B (en) Gdf-8 inhibitors
IL235737A0 (en) Neprilysin inhibitors
HK1211927A1 (en) Aggrecanase inhibitors
SG11201500973WA (en) Amino-quinolines as kinase inhibitors
HK1209422A1 (en) Fbxo3 inhibitors fbxo3
EP2882430A4 (en) ANTIBACTERIAL INHIBITORS