HK1211923A1 - Polycyclic estrogen receptor modulators and uses thereof - Google Patents

Polycyclic estrogen receptor modulators and uses thereof

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Publication number
HK1211923A1
HK1211923A1 HK15112674.1A HK15112674A HK1211923A1 HK 1211923 A1 HK1211923 A1 HK 1211923A1 HK 15112674 A HK15112674 A HK 15112674A HK 1211923 A1 HK1211923 A1 HK 1211923A1
Authority
HK
Hong Kong
Prior art keywords
polycyclic
estrogen receptor
receptor modulators
modulators
estrogen
Prior art date
Application number
HK15112674.1A
Other languages
English (en)
Chinese (zh)
Inventor
Nicholas D Smith
Steven P Govek
Mehmet Kahraman
Celine Bonnefous
Jackaline D Julien
Original Assignee
Seragon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seragon Pharmaceuticals Inc filed Critical Seragon Pharmaceuticals Inc
Publication of HK1211923A1 publication Critical patent/HK1211923A1/xx

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015031903A8 (pt) 2013-06-19 2019-12-31 Seragon Pharmaceuticals Inc composto, sal farmaceuticamente aceitável, composição farmacêutica e uso de um composto
CA2915534A1 (en) 2013-06-19 2014-12-24 Seragon Pharmaceuticals, Inc. Azetidine estrogen receptor modulators and uses thereof
KR20160085915A (ko) 2013-12-06 2016-07-18 에프. 호프만-라 로슈 아게 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자
JP2017507964A (ja) 2014-03-13 2017-03-23 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト エストロゲン受容体モジュレーターを用いた治療的組合せ
US9855270B2 (en) 2014-03-13 2018-01-02 Genentech, Inc. Methods and compositions for modulating estrogen receptor mutants
AU2015303297A1 (en) 2014-08-11 2016-12-01 F. Hoffmann-La Roche Ag Crystalline forms of an estrogen receptor modulator
EP3303326B1 (en) 2015-05-26 2020-12-16 H. Hoffnabb-La Roche Ag Heterocyclic estrogen receptor modulators and uses thereof
EP3312184A4 (en) 2015-06-16 2019-02-27 Jiangsu Hengrui Medicine Co., Ltd. PIPERIDINE DERIVATIVE AND ITS PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
WO2017060326A1 (en) 2015-10-07 2017-04-13 F. Hoffmann-La Roche Ag Process for the preparation of (e)-3-(4-((e)-2-(2-chloro-4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid
AU2016366680B2 (en) 2015-12-09 2021-06-24 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective estrogen receptor downregulators
EP3395809A4 (en) 2015-12-22 2019-06-19 Jiangsu Hengrui Medicine Co. Ltd. BENZOPIPERIDIN DERIVATIVE, PRODUCTION METHOD AND MEDICAL USE THEREOF
WO2017136688A1 (en) 2016-02-05 2017-08-10 Inventisbio Inc. Selective estrogen receptor degraders and uses thereof
IL295050A (en) 2016-04-01 2022-09-01 Recurium Ip Holdings Llc Estrogen receptor modulators
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
IL267795B2 (en) 2017-01-06 2023-02-01 G1 Therapeutics Inc Combined treatment for cancer
JP2020507566A (ja) 2017-02-10 2020-03-12 ジー1 セラピューティクス, インコーポレイテッド ベンゾチオフェンエストロゲン受容体モジュレーター
NZ764463A (en) 2017-11-14 2023-07-28 Kind Pharmaceutical Heterocyclic compound and application thereof in medicine
CA3109090A1 (en) 2018-08-17 2020-02-20 F. Hoffmann-La Roche Ag Diagnostic and therapeutic methods for the treatment of breast cancer
JP2022543832A (ja) 2019-08-06 2022-10-14 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー 変異体を治療するためのエストロゲン受容体調節剤
MX2022008091A (es) 2020-01-10 2022-07-11 Jiangsu Hengrui Medicine Co Derivado de tetrahidroisoquinolina triciclica, metodo de preparacion del mismo y aplicacion del mismo en medicina.
EP4267578A1 (en) 2020-12-23 2023-11-01 Recurium IP Holdings, LLC Estrogen receptor modulators
KR102503296B1 (ko) * 2021-05-18 2023-02-24 재단법인 대구경북첨단의료산업진흥재단 신규 에텐 화합물 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
WO2022245124A1 (ko) * 2021-05-18 2022-11-24 재단법인 대구경북첨단의료산업진흥재단 신규 에텐 화합물 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
JP2024525643A (ja) 2021-07-09 2024-07-12 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 三環式テトラヒドロイソキノリン系誘導体の塩の形態

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58157779A (ja) * 1982-03-13 1983-09-19 Kanzaki Paper Mfg Co Ltd フタリド誘導体、その製造方法およびその誘導体を用いた感熱記録体
JPS62211185A (ja) * 1986-03-11 1987-09-17 Yamada Kagaku Kogyo Kk 発色性記録材料
JPH05212957A (ja) * 1991-07-26 1993-08-24 Yamada Chem Co Ltd 感圧記録材料
US6528681B2 (en) 2000-04-05 2003-03-04 Bristol-Meyers Squibb Pharma Company Halogenated triphenylethylene derivatives as selective estrogen receptor modulators
HUP0500573A2 (hu) * 2001-08-11 2005-11-28 Bristol-Myers Squibb Pharma Company Trifenil-etilén származékok, mint szelektív ösztrogén receptor modulátorok és ezeket tartalmazó gyógyszerkészítmények
DE602004014806D1 (de) * 2003-10-08 2008-08-14 Smithkline Beecham Corp Triphenylethyleneverbindungen als selektive modulatoren des östrogenrezeptors
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
JP6154887B2 (ja) 2012-03-20 2017-06-28 セラゴン ファーマシューティカルズ,インク. エストロゲン受容体モジュレーターおよびその使用
KR20160085915A (ko) 2013-12-06 2016-07-18 에프. 호프만-라 로슈 아게 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자
US9855270B2 (en) 2014-03-13 2018-01-02 Genentech, Inc. Methods and compositions for modulating estrogen receptor mutants

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