HK1211923A1 - Polycyclic estrogen receptor modulators and uses thereof - Google Patents
Polycyclic estrogen receptor modulators and uses thereofInfo
- Publication number
- HK1211923A1 HK1211923A1 HK15112674.1A HK15112674A HK1211923A1 HK 1211923 A1 HK1211923 A1 HK 1211923A1 HK 15112674 A HK15112674 A HK 15112674A HK 1211923 A1 HK1211923 A1 HK 1211923A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- polycyclic
- estrogen receptor
- receptor modulators
- modulators
- estrogen
- Prior art date
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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US201361784578P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/026632 WO2014151899A1 (en) | 2013-03-14 | 2014-03-13 | Polycyclic estrogen receptor modulators and uses thereof |
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HK1211923A1 true HK1211923A1 (en) | 2016-06-03 |
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HK15112674.1A HK1211923A1 (en) | 2013-03-14 | 2015-12-24 | Polycyclic estrogen receptor modulators and uses thereof |
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US (1) | US9586952B2 (ja) |
EP (1) | EP2970130A4 (ja) |
JP (1) | JP2016517420A (ja) |
KR (1) | KR20150129723A (ja) |
CN (1) | CN105121413B (ja) |
BR (1) | BR112015022566A2 (ja) |
CA (1) | CA2899969A1 (ja) |
HK (1) | HK1211923A1 (ja) |
MX (1) | MX2015011132A (ja) |
RU (1) | RU2015138964A (ja) |
WO (1) | WO2014151899A1 (ja) |
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BR112015031903A8 (pt) | 2013-06-19 | 2019-12-31 | Seragon Pharmaceuticals Inc | composto, sal farmaceuticamente aceitável, composição farmacêutica e uso de um composto |
CA2915534A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Azetidine estrogen receptor modulators and uses thereof |
KR20160085915A (ko) | 2013-12-06 | 2016-07-18 | 에프. 호프만-라 로슈 아게 | 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자 |
JP2017507964A (ja) | 2014-03-13 | 2017-03-23 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | エストロゲン受容体モジュレーターを用いた治療的組合せ |
US9855270B2 (en) | 2014-03-13 | 2018-01-02 | Genentech, Inc. | Methods and compositions for modulating estrogen receptor mutants |
AU2015303297A1 (en) | 2014-08-11 | 2016-12-01 | F. Hoffmann-La Roche Ag | Crystalline forms of an estrogen receptor modulator |
EP3303326B1 (en) | 2015-05-26 | 2020-12-16 | H. Hoffnabb-La Roche Ag | Heterocyclic estrogen receptor modulators and uses thereof |
EP3312184A4 (en) | 2015-06-16 | 2019-02-27 | Jiangsu Hengrui Medicine Co., Ltd. | PIPERIDINE DERIVATIVE AND ITS PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF |
WO2017060326A1 (en) | 2015-10-07 | 2017-04-13 | F. Hoffmann-La Roche Ag | Process for the preparation of (e)-3-(4-((e)-2-(2-chloro-4-fluorophenyl)-1-(1h-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid |
AU2016366680B2 (en) | 2015-12-09 | 2021-06-24 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective estrogen receptor downregulators |
EP3395809A4 (en) | 2015-12-22 | 2019-06-19 | Jiangsu Hengrui Medicine Co. Ltd. | BENZOPIPERIDIN DERIVATIVE, PRODUCTION METHOD AND MEDICAL USE THEREOF |
WO2017136688A1 (en) | 2016-02-05 | 2017-08-10 | Inventisbio Inc. | Selective estrogen receptor degraders and uses thereof |
IL295050A (en) | 2016-04-01 | 2022-09-01 | Recurium Ip Holdings Llc | Estrogen receptor modulators |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
IL267795B2 (en) | 2017-01-06 | 2023-02-01 | G1 Therapeutics Inc | Combined treatment for cancer |
JP2020507566A (ja) | 2017-02-10 | 2020-03-12 | ジー1 セラピューティクス, インコーポレイテッド | ベンゾチオフェンエストロゲン受容体モジュレーター |
NZ764463A (en) | 2017-11-14 | 2023-07-28 | Kind Pharmaceutical | Heterocyclic compound and application thereof in medicine |
CA3109090A1 (en) | 2018-08-17 | 2020-02-20 | F. Hoffmann-La Roche Ag | Diagnostic and therapeutic methods for the treatment of breast cancer |
JP2022543832A (ja) | 2019-08-06 | 2022-10-14 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 変異体を治療するためのエストロゲン受容体調節剤 |
MX2022008091A (es) | 2020-01-10 | 2022-07-11 | Jiangsu Hengrui Medicine Co | Derivado de tetrahidroisoquinolina triciclica, metodo de preparacion del mismo y aplicacion del mismo en medicina. |
EP4267578A1 (en) | 2020-12-23 | 2023-11-01 | Recurium IP Holdings, LLC | Estrogen receptor modulators |
KR102503296B1 (ko) * | 2021-05-18 | 2023-02-24 | 재단법인 대구경북첨단의료산업진흥재단 | 신규 에텐 화합물 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
WO2022245124A1 (ko) * | 2021-05-18 | 2022-11-24 | 재단법인 대구경북첨단의료산업진흥재단 | 신규 에텐 화합물 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
JP2024525643A (ja) | 2021-07-09 | 2024-07-12 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 三環式テトラヒドロイソキノリン系誘導体の塩の形態 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS58157779A (ja) * | 1982-03-13 | 1983-09-19 | Kanzaki Paper Mfg Co Ltd | フタリド誘導体、その製造方法およびその誘導体を用いた感熱記録体 |
JPS62211185A (ja) * | 1986-03-11 | 1987-09-17 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
JPH05212957A (ja) * | 1991-07-26 | 1993-08-24 | Yamada Chem Co Ltd | 感圧記録材料 |
US6528681B2 (en) | 2000-04-05 | 2003-03-04 | Bristol-Meyers Squibb Pharma Company | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators |
HUP0500573A2 (hu) * | 2001-08-11 | 2005-11-28 | Bristol-Myers Squibb Pharma Company | Trifenil-etilén származékok, mint szelektív ösztrogén receptor modulátorok és ezeket tartalmazó gyógyszerkészítmények |
DE602004014806D1 (de) * | 2003-10-08 | 2008-08-14 | Smithkline Beecham Corp | Triphenylethyleneverbindungen als selektive modulatoren des östrogenrezeptors |
GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
JP6154887B2 (ja) | 2012-03-20 | 2017-06-28 | セラゴン ファーマシューティカルズ,インク. | エストロゲン受容体モジュレーターおよびその使用 |
KR20160085915A (ko) | 2013-12-06 | 2016-07-18 | 에프. 호프만-라 로슈 아게 | 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자 |
US9855270B2 (en) | 2014-03-13 | 2018-01-02 | Genentech, Inc. | Methods and compositions for modulating estrogen receptor mutants |
-
2014
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- 2014-03-13 BR BR112015022566A patent/BR112015022566A2/pt not_active Application Discontinuation
- 2014-03-13 CN CN201480014573.8A patent/CN105121413B/zh not_active Expired - Fee Related
- 2014-03-13 KR KR1020157024740A patent/KR20150129723A/ko not_active Application Discontinuation
- 2014-03-13 US US14/851,215 patent/US9586952B2/en not_active Expired - Fee Related
- 2014-03-13 MX MX2015011132A patent/MX2015011132A/es unknown
- 2014-03-13 JP JP2016502200A patent/JP2016517420A/ja active Pending
- 2014-03-13 RU RU2015138964A patent/RU2015138964A/ru unknown
- 2014-03-13 WO PCT/US2014/026632 patent/WO2014151899A1/en active Application Filing
- 2014-03-13 CA CA2899969A patent/CA2899969A1/en not_active Abandoned
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2015
- 2015-12-24 HK HK15112674.1A patent/HK1211923A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2970130A1 (en) | 2016-01-20 |
BR112015022566A2 (pt) | 2017-07-18 |
KR20150129723A (ko) | 2015-11-20 |
CN105121413B (zh) | 2018-09-14 |
US9586952B2 (en) | 2017-03-07 |
RU2015138964A (ru) | 2017-04-18 |
JP2016517420A (ja) | 2016-06-16 |
CA2899969A1 (en) | 2014-09-25 |
EP2970130A4 (en) | 2016-08-03 |
CN105121413A (zh) | 2015-12-02 |
MX2015011132A (es) | 2015-11-30 |
WO2014151899A1 (en) | 2014-09-25 |
US20160355508A1 (en) | 2016-12-08 |
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