HK1210621A1 - Complex chromosome engineering for production of human antibodies in transgenic animals - Google Patents
Complex chromosome engineering for production of human antibodies in transgenic animalsInfo
- Publication number
- HK1210621A1 HK1210621A1 HK15111388.0A HK15111388A HK1210621A1 HK 1210621 A1 HK1210621 A1 HK 1210621A1 HK 15111388 A HK15111388 A HK 15111388A HK 1210621 A1 HK1210621 A1 HK 1210621A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- production
- human antibodies
- transgenic animals
- chromosome engineering
- complex chromosome
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title 1
- 210000000349 chromosome Anatomy 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/208—Pseudochromosomes, minichrosomosomes of mammalian origin, e.g. minichromosome
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261679288P | 2012-08-03 | 2012-08-03 | |
PCT/US2013/053618 WO2014022853A1 (en) | 2012-08-03 | 2013-08-05 | Complex chromosome engineering for production of human antibodies in transgenic animals |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1210621A1 true HK1210621A1 (en) | 2016-04-29 |
Family
ID=48949296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15111388.0A HK1210621A1 (en) | 2012-08-03 | 2015-11-18 | Complex chromosome engineering for production of human antibodies in transgenic animals |
Country Status (10)
Country | Link |
---|---|
US (1) | US9902970B2 (ja) |
EP (1) | EP2880055B1 (ja) |
JP (1) | JP6426606B2 (ja) |
KR (1) | KR102159163B1 (ja) |
CN (1) | CN104755493B (ja) |
AU (1) | AU2013296182B2 (ja) |
HK (1) | HK1210621A1 (ja) |
IN (1) | IN2015DN01700A (ja) |
NZ (1) | NZ703973A (ja) |
WO (1) | WO2014022853A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104904661B (zh) * | 2015-06-05 | 2018-07-24 | 杭州正因生物技术有限公司 | 一种人源化小鼠 |
US11072649B2 (en) * | 2015-11-25 | 2021-07-27 | Sab, Llc | Systems and methods for the production of human polyclonal antibodies |
US20190254264A1 (en) * | 2016-10-31 | 2019-08-22 | National University Corporation Tottori University | Human antibody-producing non-human animal and method for preparing human antibodies using same |
WO2019015677A1 (en) * | 2017-07-21 | 2019-01-24 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED IMMUNOGLOBULIN HEAVY CHAIN ANIMALS |
CN108486126A (zh) * | 2018-03-27 | 2018-09-04 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在人源化抗体中的应用 |
CN108486125B (zh) * | 2018-03-27 | 2024-01-05 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在制备人源单域抗体中的应用 |
CN110128524B (zh) * | 2019-06-04 | 2021-05-07 | 中国农业科学院兰州兽医研究所 | 猪IgA+ B细胞类别转换标志物序列及检测方法 |
US20210246197A1 (en) * | 2020-02-12 | 2021-08-12 | Sab, Llc. | Anti-thymocyte globulin |
CN116194475A (zh) | 2020-08-31 | 2023-05-30 | Sab有限责任公司 | 对冠状病毒蛋白具有特异性的有蹄类动物源性多克隆免疫球蛋白和其用途 |
WO2022104127A1 (en) * | 2020-11-13 | 2022-05-19 | SAB Biotherapeutics, Inc. | Ungulate-derived polyclonal immunoglobulin specific for egfr and uses thereof |
WO2023102398A2 (en) * | 2021-11-30 | 2023-06-08 | Sab, Llc | Ungulate-derived polyclonal immunoglobulin specific for influenza virus and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
NZ525664A (en) * | 2000-11-17 | 2008-08-29 | Kirin Holdings Kk | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
US7476536B2 (en) * | 2001-05-11 | 2009-01-13 | Kirin Pharma Kabushiki Kaisha | Artificial human chromosome containing human antibody a light chain gene |
CA2484655A1 (en) * | 2002-05-17 | 2003-11-27 | Hematech, Llc | Transgenic ungulates capable of human antibody production |
WO2005007696A2 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
WO2010003990A1 (en) * | 2008-07-10 | 2010-01-14 | Frewitt Fabrique De Machines S.A. | Bead mill with separator |
AU2009298458B2 (en) * | 2008-09-30 | 2015-10-08 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
JP5796846B2 (ja) * | 2009-11-17 | 2015-10-21 | エスエービー エルエルシー | ヒト人工染色体ベクター |
WO2012157589A1 (ja) * | 2011-05-13 | 2012-11-22 | 国立大学法人宮崎大学 | 細胞接着阻害剤、細胞増殖阻害剤、並びに癌の検査方法および検査用キット |
-
2013
- 2013-08-05 CN CN201380041315.4A patent/CN104755493B/zh active Active
- 2013-08-05 IN IN1700DEN2015 patent/IN2015DN01700A/en unknown
- 2013-08-05 AU AU2013296182A patent/AU2013296182B2/en active Active
- 2013-08-05 NZ NZ703973A patent/NZ703973A/en unknown
- 2013-08-05 EP EP13747631.3A patent/EP2880055B1/en active Active
- 2013-08-05 US US14/416,870 patent/US9902970B2/en active Active
- 2013-08-05 KR KR1020157005433A patent/KR102159163B1/ko active IP Right Grant
- 2013-08-05 WO PCT/US2013/053618 patent/WO2014022853A1/en active Application Filing
- 2013-08-05 JP JP2015525643A patent/JP6426606B2/ja active Active
-
2015
- 2015-11-18 HK HK15111388.0A patent/HK1210621A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2013296182A1 (en) | 2015-02-19 |
EP2880055A1 (en) | 2015-06-10 |
US9902970B2 (en) | 2018-02-27 |
KR20150039820A (ko) | 2015-04-13 |
WO2014022853A1 (en) | 2014-02-06 |
CN104755493B (zh) | 2020-12-25 |
AU2013296182B2 (en) | 2018-03-08 |
US20150211020A1 (en) | 2015-07-30 |
KR102159163B1 (ko) | 2020-09-23 |
NZ703973A (en) | 2018-04-27 |
EP2880055B1 (en) | 2017-06-28 |
CN104755493A (zh) | 2015-07-01 |
JP6426606B2 (ja) | 2018-11-21 |
JP2016504012A (ja) | 2016-02-12 |
IN2015DN01700A (ja) | 2015-05-22 |
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