HK1210478A1 - Rtrail mutant and monomethyl auristatin e conjugate thereof rtrail - Google Patents
Rtrail mutant and monomethyl auristatin e conjugate thereof rtrailInfo
- Publication number
- HK1210478A1 HK1210478A1 HK15111182.8A HK15111182A HK1210478A1 HK 1210478 A1 HK1210478 A1 HK 1210478A1 HK 15111182 A HK15111182 A HK 15111182A HK 1210478 A1 HK1210478 A1 HK 1210478A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- rtrail
- conjugate
- mutant
- monomethyl auristatin
- auristatin
- Prior art date
Links
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 title 1
- 108010093470 monomethyl auristatin E Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104166488A CN102936281B (zh) | 2012-10-25 | 2012-10-25 | 一种rTRAIL突变体及其海兔毒素偶联物 |
| PCT/CN2013/077566 WO2014063495A1 (zh) | 2012-10-25 | 2013-06-20 | 一种rTRAIL突变体及其海兔毒素偶联物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1210478A1 true HK1210478A1 (en) | 2016-04-22 |
Family
ID=47695213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15111182.8A HK1210478A1 (en) | 2012-10-25 | 2015-11-12 | Rtrail mutant and monomethyl auristatin e conjugate thereof rtrail |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9617326B2 (xx) |
| EP (1) | EP2924048B1 (xx) |
| JP (1) | JP6209616B2 (xx) |
| KR (1) | KR102050621B1 (xx) |
| CN (1) | CN102936281B (xx) |
| AU (1) | AU2013334334B2 (xx) |
| HK (1) | HK1210478A1 (xx) |
| WO (1) | WO2014063495A1 (xx) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102936281B (zh) | 2012-10-25 | 2013-12-25 | 浙江大学 | 一种rTRAIL突变体及其海兔毒素偶联物 |
| WO2014141094A1 (en) * | 2013-03-14 | 2014-09-18 | Adamed Sp. Z O.O. | Anticancer conjugate |
| CN104342444B (zh) * | 2013-07-23 | 2017-11-17 | 四川大学华西医院 | 一种重组trail蛋白及其制备方法和用途 |
| CN103408654B (zh) * | 2013-08-07 | 2014-12-31 | 浙江大学 | 一种rTRAIL突变体-单甲基化聚乙二醇马来酰亚胺偶联物及其应用 |
| CN104744584B (zh) * | 2015-03-25 | 2018-09-28 | 浙江大学 | 一种聚乙二醇-rTRAIL突变体三聚体-海兔毒素偶联物及其制备方法和应用 |
| CN107375941A (zh) * | 2017-07-17 | 2017-11-24 | 中国药科大学 | 一种抗人dll4单克隆抗体与海兔毒素衍生物mmae的偶联物 |
| WO2022080865A2 (ko) * | 2020-10-13 | 2022-04-21 | 신동준 | 반려견의 항암용 재조합 단백질 및 이를 포함하는 반려견을 위한 항암용 조성물 |
| CN117412761A (zh) * | 2021-05-19 | 2024-01-16 | 拜奥海芬治疗学有限公司 | 使用mate技术的用于递送细胞毒性药剂的抗体药物缀合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635483A (en) * | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| JP2005508162A (ja) * | 2001-10-02 | 2005-03-31 | ジェネンテック・インコーポレーテッド | Ａｐｏ−２リガンド変異体とその使用法 |
| EP1482972A4 (en) * | 2001-11-20 | 2005-11-23 | Seattle Genetics Inc | TREATMENT OF IMMUNOLOGICAL DISORDERS USING ANTI-CD30 ANTIBODIES |
| CN1205335C (zh) * | 2001-11-30 | 2005-06-08 | 中国人民解放军第二军医大学 | 肿瘤凋亡诱导配体基因、基因表达蛋白及其制备方法 |
| CN1239516C (zh) * | 2002-02-08 | 2006-02-01 | 中国医学科学院基础医学研究所 | 肿瘤坏死因子相关细胞凋亡诱导配体胞外区突变多肽及其制法与用途 |
| KR100814066B1 (ko) | 2005-04-27 | 2008-03-17 | 연세대학교 산학협력단 | Ｔｒａｉｌ을 분비하는 인간의 신경줄기세포, 이의제조방법 및 용도 |
| GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
| GB0724532D0 (en) * | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| JP2013505944A (ja) * | 2009-09-24 | 2013-02-21 | シアトル ジェネティックス， インコーポレイテッド | Ｄｒ５リガンド薬物結合体 |
| CN102898526A (zh) * | 2011-07-28 | 2013-01-30 | 山东先声麦得津生物制药有限公司 | 一种肿瘤坏死因子相关凋亡诱导配体融合蛋白及其制备和应用 |
| CN102936281B (zh) * | 2012-10-25 | 2013-12-25 | 浙江大学 | 一种rTRAIL突变体及其海兔毒素偶联物 |
-
2012
- 2012-10-25 CN CN2012104166488A patent/CN102936281B/zh active Active
-
2013
- 2013-06-20 US US14/437,987 patent/US9617326B2/en active Active
- 2013-06-20 EP EP13848770.7A patent/EP2924048B1/en not_active Not-in-force
- 2013-06-20 KR KR1020157013621A patent/KR102050621B1/ko active IP Right Grant
- 2013-06-20 WO PCT/CN2013/077566 patent/WO2014063495A1/zh active Application Filing
- 2013-06-20 AU AU2013334334A patent/AU2013334334B2/en not_active Ceased
- 2013-06-20 JP JP2015538259A patent/JP6209616B2/ja not_active Expired - Fee Related
-
2015
- 2015-11-12 HK HK15111182.8A patent/HK1210478A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014063495A1 (zh) | 2014-05-01 |
| EP2924048A1 (en) | 2015-09-30 |
| JP2015533838A (ja) | 2015-11-26 |
| KR20150079771A (ko) | 2015-07-08 |
| JP6209616B2 (ja) | 2017-10-04 |
| KR102050621B1 (ko) | 2019-11-29 |
| CN102936281B (zh) | 2013-12-25 |
| EP2924048B1 (en) | 2018-02-14 |
| CN102936281A (zh) | 2013-02-20 |
| AU2013334334A1 (en) | 2015-05-14 |
| US9617326B2 (en) | 2017-04-11 |
| AU2013334334B2 (en) | 2017-10-19 |
| US20150307587A1 (en) | 2015-10-29 |
| EP2924048A4 (en) | 2016-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20220619 |