HK1209426A1 - 培美曲塞及其賴氨酸鹽的製備方法 - Google Patents
培美曲塞及其賴氨酸鹽的製備方法Info
- Publication number
- HK1209426A1 HK1209426A1 HK15110234.8A HK15110234A HK1209426A1 HK 1209426 A1 HK1209426 A1 HK 1209426A1 HK 15110234 A HK15110234 A HK 15110234A HK 1209426 A1 HK1209426 A1 HK 1209426A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pemetrexed
- preparation
- lysin salt
- lysin
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000398A ITRM20120398A1 (it) | 2012-08-08 | 2012-08-08 | Procedimento di sintesi pemetrexed e suo sale di lisina. |
| PCT/IB2013/056497 WO2014024164A1 (en) | 2012-08-08 | 2013-08-08 | Process for the preparation of pemetrexed and lysin salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1209426A1 true HK1209426A1 (zh) | 2016-04-01 |
Family
ID=47018368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15110234.8A HK1209426A1 (zh) | 2012-08-08 | 2015-10-19 | 培美曲塞及其賴氨酸鹽的製備方法 |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP2882753B1 (zh) |
| KR (1) | KR102288417B1 (zh) |
| CN (1) | CN104736540B (zh) |
| AU (1) | AU2013301156B2 (zh) |
| BR (1) | BR112015002429A8 (zh) |
| CY (1) | CY1118514T1 (zh) |
| DK (1) | DK2882753T3 (zh) |
| ES (1) | ES2607890T3 (zh) |
| HK (1) | HK1209426A1 (zh) |
| HR (1) | HRP20170011T1 (zh) |
| HU (1) | HUE032304T2 (zh) |
| IN (1) | IN2015DN00833A (zh) |
| IT (1) | ITRM20120398A1 (zh) |
| LT (1) | LT2882753T (zh) |
| MX (1) | MX362858B (zh) |
| PL (1) | PL2882753T3 (zh) |
| PT (1) | PT2882753T (zh) |
| RS (1) | RS55515B1 (zh) |
| RU (1) | RU2609006C2 (zh) |
| SI (1) | SI2882753T1 (zh) |
| SM (1) | SMT201600474B (zh) |
| TW (1) | TWI609017B (zh) |
| WO (1) | WO2014024164A1 (zh) |
| ZA (1) | ZA201501549B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107641124A (zh) * | 2016-07-22 | 2018-01-30 | 上海创诺制药有限公司 | 一种培美曲塞二酸新晶型及其制备方法 |
| CN109836425B (zh) * | 2017-11-24 | 2023-01-24 | 江苏创诺制药有限公司 | 一种合成培美酸的制备工艺 |
| CN110128428A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞丙氨酸盐 |
| CN110128426B (zh) * | 2018-02-09 | 2021-12-14 | 鲁南制药集团股份有限公司 | 培美曲塞谷氨酸盐 |
| CN110128427A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞缬氨酸盐 |
| CN111333658A (zh) * | 2020-05-06 | 2020-06-26 | 贵州联科中贝制药科技有限公司 | 一种培美曲塞二钠水合物的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005128A1 (en) | 1988-10-31 | 1990-05-17 | Mitsui Toatsu Chemicals, Inc. | Process for preparing organic group-substituted sodium aluminum hydride |
| KR0162654B1 (ko) | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| IL96531A (en) | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| CZ283281B6 (cs) * | 1992-09-25 | 1998-02-18 | Eli Lilly And Company | Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů |
| US5416211A (en) | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
| DE19725647A1 (de) | 1997-06-18 | 1998-12-24 | Basf Ag | Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme |
| ZA987550B (en) | 1997-09-26 | 2000-02-21 | Lilly Co Eli | Processes and intermediates useful to make antifolates. |
| ATE249462T1 (de) | 2000-02-25 | 2003-09-15 | Lilly Co Eli | Neue kristalline form von n-(4-(2-(2-amino-4,7- dihydro-4-oxo-3h-pyrrolo(2,3-d)-pyrimidin-5- yl)ethyl)benzoyl)-l-glutaminsäure und verfahren für ihre herstellung |
| WO2008021410A2 (en) * | 2006-08-14 | 2008-02-21 | Sicor Inc. | Highly pure pemetrexed diacid and processes for the preparation thereof |
| WO2008021385A2 (en) | 2006-08-14 | 2008-02-21 | Sicor Inc. | Processes for preparing intermediates of pemetrexed |
| CN101591247B (zh) * | 2008-05-30 | 2012-09-05 | 上海希迪制药有限公司 | 合成4-(4-甲酯基苯基)丁醛的方法 |
| IT1401677B1 (it) * | 2010-07-22 | 2013-08-02 | Chemi Spa | Nuovo processo per la sintesi di pemetrexed sale disodico |
| JP2013540104A (ja) | 2010-07-28 | 2013-10-31 | イーグル・ファーマシューティカルズ・インコーポレーテッド | 延長された保存安定性を有するペメトレキセドを含有する医薬組成物 |
| WO2012056285A1 (en) * | 2010-10-25 | 2012-05-03 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of pemetrexed |
-
2012
- 2012-08-08 IT IT000398A patent/ITRM20120398A1/it unknown
-
2013
- 2013-08-06 TW TW102128058A patent/TWI609017B/zh active
- 2013-08-08 BR BR112015002429A patent/BR112015002429A8/pt not_active Application Discontinuation
- 2013-08-08 LT LTEP13777144.0T patent/LT2882753T/lt unknown
- 2013-08-08 WO PCT/IB2013/056497 patent/WO2014024164A1/en active Application Filing
- 2013-08-08 RS RS20161202A patent/RS55515B1/sr unknown
- 2013-08-08 PL PL13777144T patent/PL2882753T3/pl unknown
- 2013-08-08 MX MX2015001712A patent/MX362858B/es active IP Right Grant
- 2013-08-08 EP EP13777144.0A patent/EP2882753B1/en active Active
- 2013-08-08 PT PT137771440T patent/PT2882753T/pt unknown
- 2013-08-08 RU RU2015108042A patent/RU2609006C2/ru active
- 2013-08-08 DK DK13777144.0T patent/DK2882753T3/en active
- 2013-08-08 SI SI201330427A patent/SI2882753T1/sl unknown
- 2013-08-08 HU HUE13777144A patent/HUE032304T2/en unknown
- 2013-08-08 IN IN833DEN2015 patent/IN2015DN00833A/en unknown
- 2013-08-08 CN CN201380041935.8A patent/CN104736540B/zh active Active
- 2013-08-08 KR KR1020157005932A patent/KR102288417B1/ko active IP Right Grant
- 2013-08-08 ES ES13777144.0T patent/ES2607890T3/es active Active
- 2013-08-08 AU AU2013301156A patent/AU2013301156B2/en active Active
-
2015
- 2015-03-06 ZA ZA2015/01549A patent/ZA201501549B/en unknown
- 2015-10-19 HK HK15110234.8A patent/HK1209426A1/zh unknown
-
2016
- 2016-12-28 SM SM201600474T patent/SMT201600474B/it unknown
- 2016-12-28 CY CY20161101351T patent/CY1118514T1/el unknown
-
2017
- 2017-01-05 HR HRP20170011TT patent/HRP20170011T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM20120398A1 (it) | 2014-02-09 |
| CN104736540A (zh) | 2015-06-24 |
| PL2882753T3 (pl) | 2017-04-28 |
| EP2882753A1 (en) | 2015-06-17 |
| TWI609017B (zh) | 2017-12-21 |
| PT2882753T (pt) | 2016-12-27 |
| BR112015002429A2 (pt) | 2017-07-04 |
| ZA201501549B (en) | 2016-01-27 |
| WO2014024164A1 (en) | 2014-02-13 |
| TW201412741A (zh) | 2014-04-01 |
| IN2015DN00833A (zh) | 2015-06-12 |
| RU2015108042A (ru) | 2016-09-27 |
| RS55515B1 (sr) | 2017-05-31 |
| CN104736540B (zh) | 2017-08-25 |
| SMT201600474B (it) | 2017-03-08 |
| KR102288417B1 (ko) | 2021-08-11 |
| AU2013301156B2 (en) | 2017-08-31 |
| MX2015001712A (es) | 2015-08-14 |
| LT2882753T (lt) | 2016-12-12 |
| RU2609006C2 (ru) | 2017-01-30 |
| BR112015002429A8 (pt) | 2019-07-30 |
| MX362858B (es) | 2019-02-20 |
| CY1118514T1 (el) | 2017-07-12 |
| HRP20170011T1 (hr) | 2017-03-10 |
| KR20150045458A (ko) | 2015-04-28 |
| ES2607890T3 (es) | 2017-04-04 |
| SI2882753T1 (sl) | 2017-02-28 |
| DK2882753T3 (en) | 2017-01-16 |
| HUE032304T2 (en) | 2017-09-28 |
| AU2013301156A1 (en) | 2015-02-05 |
| EP2882753B1 (en) | 2016-10-05 |
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