HK1208731A1 - 用於檢測多特異性結合物的方法 - Google Patents

用於檢測多特異性結合物的方法

Info

Publication number
HK1208731A1
HK1208731A1 HK15109419.7A HK15109419A HK1208731A1 HK 1208731 A1 HK1208731 A1 HK 1208731A1 HK 15109419 A HK15109419 A HK 15109419A HK 1208731 A1 HK1208731 A1 HK 1208731A1
Authority
HK
Hong Kong
Prior art keywords
detection
multispecific binder
multispecific
binder
Prior art date
Application number
HK15109419.7A
Other languages
English (en)
Inventor
Kay-Gunnar Stubenrauch
Markus Zadak
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1208731A1 publication Critical patent/HK1208731A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK15109419.7A 2012-07-13 2015-09-24 用於檢測多特異性結合物的方法 HK1208731A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12176342 2012-07-13
PCT/EP2013/064683 WO2014009474A1 (en) 2012-07-13 2013-07-11 Method for the detection of a multispecific binder

Publications (1)

Publication Number Publication Date
HK1208731A1 true HK1208731A1 (zh) 2016-03-11

Family

ID=48782335

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15109419.7A HK1208731A1 (zh) 2012-07-13 2015-09-24 用於檢測多特異性結合物的方法

Country Status (12)

Country Link
US (1) US9488662B2 (zh)
EP (1) EP2872893B1 (zh)
JP (1) JP6226976B2 (zh)
KR (1) KR20150038046A (zh)
CN (1) CN104471397B (zh)
BR (1) BR112015000665A2 (zh)
CA (1) CA2873829A1 (zh)
ES (1) ES2627482T3 (zh)
HK (1) HK1208731A1 (zh)
MX (1) MX346146B (zh)
RU (1) RU2636822C2 (zh)
WO (1) WO2014009474A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013113663A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
CN105683755B (zh) * 2013-11-05 2019-08-13 豪夫迈·罗氏有限公司 陷阱分子和检测分子的用途及其相关试剂盒和组合物
RU2678108C2 (ru) 2014-04-23 2019-01-23 Нитирей Байосайенсиз Инк. Комбинированный продукт для детекции маркера-мишени
MX2018005036A (es) * 2015-10-29 2018-08-01 Hoffmann La Roche Anticuerpos y metodos de uso de anti-regiones de fragmentos cristalizables (fc) variantes.
JP6807944B2 (ja) * 2015-11-30 2021-01-06 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｆｃ領域改変抗体を測定するためのイムノアッセイ法
WO2019235420A1 (ja) 2018-06-04 2019-12-12 中外製薬株式会社 複合体を検出する方法
EP3969907A1 (en) * 2019-05-13 2022-03-23 F. Hoffmann-La Roche AG Interference-suppressed pharmacokinetic immunoassay
WO2024163318A1 (en) * 2023-01-30 2024-08-08 Amgen Inc. System and method for analyzing antibody co-formulations

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US5219730A (en) 1982-09-28 1993-06-15 New York University Idiotype-anti-idiotype immunoassay
US4828981A (en) 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
EP0170302A1 (fr) 1984-06-27 1986-02-05 l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
EP0243471A4 (en) 1985-10-22 1989-07-11 Cooper Lipotech Inc SOLID PHASE LIPOSOME IMMUNOANALYSIS SYSTEM.
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
JP2992974B2 (ja) 1988-11-03 1999-12-20 イゲン，インコーポレーテッド 電気化学ルミネセンス検定
IL100866A (en) 1991-02-06 1995-10-31 Igen Inc Luminescence test method and device based on magnetic tiny particles, containing many magnets
EP0651761B1 (en) 1992-07-13 2002-10-09 Bionebraska, Inc. Method for modification of recombinant polypeptides
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US6753189B1 (en) 1998-06-04 2004-06-22 Mizuho Medy Co., Ltd. Detection apparatus and method for the same
AU774575C (en) 1999-11-16 2005-09-08 Genentech Inc. Elisa for VEGF
US7718387B2 (en) 2001-09-20 2010-05-18 Board Of Regents, The University Of Texas System Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays
WO2006096697A2 (en) 2005-03-08 2006-09-14 Tanox, Inc. Methods for determining the bivalency of protein and antibody therapeutics
KR101551984B1 (ko) 2006-10-04 2015-09-09 제넨테크, 인크. Ｖｅｇｆ용 ｅｌｉｓａ
EP1917854A1 (en) 2006-11-06 2008-05-07 F. Hoffmann-La Roche Ag Method for producing anti idiotypic antibodies
CA2681974C (en) * 2007-03-29 2019-12-31 Genmab A/S Bispecific antibodies and methods for production thereof
TWI570135B (zh) 2007-04-27 2017-02-11 建南德克公司 高效、穩定且非免疫抑制之抗－ｃｄ４抗體
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
JP5634405B2 (ja) * 2008-10-07 2014-12-03 ユィロス・パテント・アクチボラグＧｙｒｏｓ Ｐａｔｅｎｔ ＡＢ 試料中のアナライトの検出のための半逐次アッセイ
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
SG175004A1 (en) 2009-04-02 2011-11-28 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
WO2010115589A1 (en) 2009-04-07 2010-10-14 Roche Glycart Ag Trivalent, bispecific antibodies
PE20120540A1 (es) 2009-05-27 2012-05-09 Hoffmann La Roche Anticuerpos triespecificos o tetraespecificos
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
CN102207504A (zh) 2011-03-23 2011-10-05 北京华创远航科技有限公司 一种酶联检测试剂盒及其制备方法
BR112014011535A2 (pt) 2011-12-19 2017-05-09 Hoffmann La Roche método para a determinação in vitro e imunológica de presença da presença e/ou da quantidade de um parceiro de ligação, método in vitro e utilização de um anticorpo
WO2013113663A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder

Also Published As

Publication number Publication date
CA2873829A1 (en) 2014-01-16
JP6226976B2 (ja) 2017-11-08
MX2014014566A (es) 2015-02-20
WO2014009474A1 (en) 2014-01-16
MX346146B (es) 2017-03-09
RU2636822C2 (ru) 2017-11-28
US20150198608A1 (en) 2015-07-16
US9488662B2 (en) 2016-11-08
CN104471397B (zh) 2018-03-23
KR20150038046A (ko) 2015-04-08
JP2015522171A (ja) 2015-08-03
EP2872893B1 (en) 2017-03-29
ES2627482T3 (es) 2017-07-28
EP2872893A1 (en) 2015-05-20
BR112015000665A2 (pt) 2017-06-27
CN104471397A (zh) 2015-03-25
RU2015104737A (ru) 2016-08-27

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