HK1208366A1 - Biofilm prevention, disruption and treatment with bacteriophage lysin - Google Patents
Biofilm prevention, disruption and treatment with bacteriophage lysinInfo
- Publication number
- HK1208366A1 HK1208366A1 HK15109108.3A HK15109108A HK1208366A1 HK 1208366 A1 HK1208366 A1 HK 1208366A1 HK 15109108 A HK15109108 A HK 15109108A HK 1208366 A1 HK1208366 A1 HK 1208366A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- disruption
- treatment
- bacteriophage lysin
- biofilm prevention
- biofilm
- Prior art date
Links
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 241001515965 unidentified phage Species 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/40—Viruses, e.g. bacteriophages
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261644799P | 2012-05-09 | 2012-05-09 | |
US201261736813P | 2012-12-13 | 2012-12-13 | |
PCT/US2013/040340 WO2013170022A1 (en) | 2012-05-09 | 2013-05-09 | Biofilm prevention, disruption and treatment with bacteriophage lysin |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1208366A1 true HK1208366A1 (en) | 2016-03-04 |
Family
ID=49551275
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15109108.3A HK1208366A1 (en) | 2012-05-09 | 2015-09-17 | Biofilm prevention, disruption and treatment with bacteriophage lysin |
HK16100031.3A HK1212208A1 (en) | 2012-05-09 | 2016-01-05 | Biofilm prevention, disruption and treatment with bacteriophage lysin |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16100031.3A HK1212208A1 (en) | 2012-05-09 | 2016-01-05 | Biofilm prevention, disruption and treatment with bacteriophage lysin |
Country Status (16)
Country | Link |
---|---|
US (4) | US9499594B2 (xx) |
EP (2) | EP3513807A1 (xx) |
JP (4) | JP6348901B2 (xx) |
KR (4) | KR20200023521A (xx) |
CN (2) | CN104780933B (xx) |
AU (3) | AU2013259427B2 (xx) |
BR (1) | BR112014027818B1 (xx) |
CA (2) | CA3187222A1 (xx) |
DK (1) | DK2846827T3 (xx) |
ES (1) | ES2729123T3 (xx) |
HK (2) | HK1208366A1 (xx) |
IL (2) | IL235526B2 (xx) |
IN (1) | IN2014MN02438A (xx) |
MX (2) | MX369056B (xx) |
RU (3) | RU2735103C2 (xx) |
WO (1) | WO2013170022A1 (xx) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
IL235527B2 (en) * | 2012-05-09 | 2023-10-01 | Contrafect Corp | Combinations of bacteriophage lysine and antibiotics against gram-positive bacteria |
WO2015200783A2 (en) | 2014-06-26 | 2015-12-30 | The Rockefeller University | Acinetobacter lysins |
CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
EP3120866A1 (en) * | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms |
WO2017134661A1 (en) | 2016-02-04 | 2017-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods for disrupting biofilms |
JP2019510076A (ja) * | 2016-02-19 | 2019-04-11 | フォルシュングスツェントルム ボルシュテル ライプニッツツェントルム フュール メディツィン ウント ビオヴィッセンシャフテン | 細菌感染症を治療するための手段と方法 |
RU2664708C1 (ru) * | 2017-06-08 | 2018-08-21 | Сергей Иванович Черныш | Способ разрушения и предотвращения образования бактериальных биопленок комплексом антимикробных пептидов насекомых |
EP3758738A4 (en) * | 2018-02-26 | 2021-12-08 | Contrafect Corporation | MODIFIED PLYSS2-LYSINE AND USES THEREOF |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
BR112021018219A2 (pt) * | 2019-03-22 | 2022-01-18 | Contrafect Corp | Método de tratamento de endocardite infecciosa |
JP2022526624A (ja) * | 2019-04-11 | 2022-05-25 | コントラフェクト コーポレイション | 骨及び関節の感染を治療及び予防する方法 |
KR102097128B1 (ko) * | 2019-06-19 | 2020-04-06 | 서울대학교산학협력단 | 황색포도상구균 제어에 효과적인 키메릭 엔도라이신 Lys109 |
CN111019876B (zh) * | 2019-12-30 | 2023-04-28 | 延安大学 | 一种铜绿假单胞菌工程菌的构建方法及应用 |
JP2023526386A (ja) * | 2020-05-19 | 2023-06-21 | コントラフェクト コーポレイション | グラム陽性細菌に対して使用される修飾PlySs2溶解素及び抗生物質の組合せ |
KR102426421B1 (ko) * | 2021-01-06 | 2022-07-29 | 주식회사 리신바이오 | 신규 재조합 엔도라이신 및 이의 용도 |
WO2024007055A1 (en) * | 2022-07-05 | 2024-01-11 | The University Of Adelaide | Method of production of modified phage and method of treatment using same |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8108587A (en) | 1986-10-08 | 1988-05-06 | David Bernstein | Method for exposing group a streptococcal antigens and an improved diagnostic test for the identification of group a streptococci |
US6264945B1 (en) | 1997-10-31 | 2001-07-24 | Vincent A Fischetti | Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections |
US6248324B1 (en) | 1997-10-31 | 2001-06-19 | Vincent Fischetti | Bacterial phage associated lysing enzymes for treating dermatological infections |
US6254866B1 (en) | 1997-10-31 | 2001-07-03 | New Horizons Diagnostics Corporation | Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract |
US20060292135A1 (en) | 1997-10-31 | 2006-12-28 | Lawrence Loomis | Use of bacterial phage-associated lysing proteins for preventing and treating bacterial infections in humans, animals and fowl |
US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
BR9917152A (pt) | 1999-02-25 | 2002-11-26 | New Horizons Diagnostics Inc | Composição para tratamento terapêutico ou profilático de infecção estreptocócica e método e uso respectivos |
US6056955A (en) | 1999-09-14 | 2000-05-02 | Fischetti; Vincent | Topical treatment of streptococcal infections |
US20040213765A1 (en) | 2001-07-13 | 2004-10-28 | Vincent Fischetti | Use of bacterial phage associated lytic enzymes to prevent food poisoning |
WO2004027020A2 (en) | 2002-05-17 | 2004-04-01 | New Horizons Diagnostics Corporation | Identification of a phage associated lytic enzyme to rapidly and specifically detect and kill bacillus anthracis |
US7569223B2 (en) | 2004-03-22 | 2009-08-04 | The Rockefeller University | Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions |
EP1744779A2 (en) | 2004-03-24 | 2007-01-24 | The Rockfeller University | Lytic enzymes and spore surface antigen for detection and treatment of "bacillus anthracis" bacteria and spores |
EP1621205A1 (en) * | 2004-07-28 | 2006-02-01 | OctoPlus Technologies B.V. | Antimicrobial peptides derived from CAP18 |
JP2008513406A (ja) * | 2004-09-22 | 2008-05-01 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
US8389469B2 (en) | 2005-06-06 | 2013-03-05 | The Rockefeller University | Bacteriophage lysins for Bacillus anthracis |
US7582291B2 (en) | 2005-06-30 | 2009-09-01 | The Rockefeller University | Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria |
JP2009506033A (ja) | 2005-08-24 | 2009-02-12 | ザ ロックフェラー ユニバーシティー | Ply−gbs突然変異ライシン |
US20080019956A1 (en) | 2006-07-24 | 2008-01-24 | Manoj Kumar | Enzymatic prevention and control of biofilm |
NO2185699T3 (xx) | 2007-08-22 | 2018-04-21 | ||
WO2009108406A2 (en) | 2008-01-10 | 2009-09-03 | Trustees Of Boston University | Engineered bacteriophages as adjuvants for antimicrobial agents and compositions and methods of use thereof |
ES2627321T3 (es) * | 2008-07-03 | 2017-07-27 | The Rockefeller University | Una lisina de bacteriófago quimérica con actividad contra bacterias estafilocócicas |
CA2739717A1 (en) * | 2008-10-10 | 2010-04-15 | Lusomedicamenta, S.A. | Antibacterial phage peptides and methods of use thereof |
KR101016918B1 (ko) | 2009-01-08 | 2011-02-25 | 주식회사 인트론바이오테크놀로지 | 박테리아 특이적 넓은 항균 활성을 갖는 신규한 리신 단백질 |
CN102414278B (zh) | 2009-05-01 | 2014-06-11 | 木本股份有限公司 | 脱模性组合物及表面保护膜 |
EP2338916A1 (en) * | 2009-12-23 | 2011-06-29 | Hyglos Invest GmbH | Chimeric polypeptides and their use in bacterial decoloniation |
EP2539446B1 (en) | 2010-01-25 | 2017-11-01 | Alere Scarborough Inc. | A25 bacteriophage lysin |
BR112012026880B1 (pt) * | 2010-04-27 | 2021-03-16 | Lysando Ag | método para eliminação ou redução de um biofilme bacteriano, variante de endolisina ou variante de bacteriocina e seus usos |
EP2397548A1 (en) * | 2010-06-18 | 2011-12-21 | Hyglos Invest GmbH | Methods of generating and screening for lytic chimeric polypeptides |
CN107189997A (zh) * | 2011-04-21 | 2017-09-22 | 洛克菲勒大学 | 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素 |
EP2699689A4 (en) * | 2011-04-21 | 2014-12-17 | Univ Utrecht Holding Bv | LYSINES OF BACTERIOPHAGES OF STREPTOCOCCUS FOR THE TREATMENT OF GRAM POSITIVE BACTERIA IN PET ANIMALS AND IN LIVESTOCK |
EP2702070B1 (en) | 2011-04-27 | 2015-09-30 | Lysando AG | New antimicrobial agents |
IL235527B2 (en) | 2012-05-09 | 2023-10-01 | Contrafect Corp | Combinations of bacteriophage lysine and antibiotics against gram-positive bacteria |
EP2835193A1 (en) | 2013-08-05 | 2015-02-11 | Refractory Intellectual Property GmbH & Co. KG | Refractory ceramic nozzle |
CN104073478A (zh) * | 2014-06-13 | 2014-10-01 | 上海交通大学 | 杀灭革兰氏阳性菌的酶抗生素及其制备、用途 |
CN104726439B (zh) * | 2015-04-13 | 2017-11-14 | 武汉菲吉乐科生物科技有限公司 | 一种广谱的链球菌裂解酶及其应用 |
CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
EP4151228A3 (en) * | 2015-09-17 | 2023-06-14 | Contrafect Corporation | Lysin polypeptides active against gram-negative bacteria |
-
2013
- 2013-05-09 KR KR1020207005447A patent/KR20200023521A/ko active Application Filing
- 2013-05-09 JP JP2015511701A patent/JP6348901B2/ja active Active
- 2013-05-09 RU RU2018102796A patent/RU2735103C2/ru active
- 2013-05-09 CN CN201380036474.5A patent/CN104780933B/zh active Active
- 2013-05-09 CN CN202010800525.9A patent/CN111803620A/zh active Pending
- 2013-05-09 EP EP19156777.5A patent/EP3513807A1/en active Pending
- 2013-05-09 KR KR1020217030507A patent/KR20210118980A/ko not_active IP Right Cessation
- 2013-05-09 AU AU2013259427A patent/AU2013259427B2/en active Active
- 2013-05-09 KR KR1020237030790A patent/KR20230135161A/ko active Application Filing
- 2013-05-09 US US14/399,588 patent/US9499594B2/en active Active
- 2013-05-09 ES ES13787555T patent/ES2729123T3/es active Active
- 2013-05-09 CA CA3187222A patent/CA3187222A1/en active Pending
- 2013-05-09 EP EP13787555.5A patent/EP2846827B1/en active Active
- 2013-05-09 IN IN2438MUN2014 patent/IN2014MN02438A/en unknown
- 2013-05-09 RU RU2014149348A patent/RU2646102C2/ru active
- 2013-05-09 MX MX2014013587A patent/MX369056B/es active IP Right Grant
- 2013-05-09 WO PCT/US2013/040340 patent/WO2013170022A1/en active Application Filing
- 2013-05-09 BR BR112014027818-0A patent/BR112014027818B1/pt active IP Right Grant
- 2013-05-09 DK DK13787555.5T patent/DK2846827T3/da active
- 2013-05-09 KR KR1020147034615A patent/KR102084388B1/ko active Application Filing
- 2013-05-09 CA CA2872911A patent/CA2872911C/en active Active
-
2014
- 2014-11-06 IL IL235526A patent/IL235526B2/en unknown
- 2014-11-07 MX MX2019012877A patent/MX2019012877A/es unknown
-
2015
- 2015-09-17 HK HK15109108.3A patent/HK1208366A1/xx unknown
-
2016
- 2016-01-05 HK HK16100031.3A patent/HK1212208A1/xx unknown
- 2016-10-14 US US15/293,586 patent/US20170127683A1/en not_active Abandoned
-
2018
- 2018-02-23 JP JP2018031017A patent/JP6873939B2/ja active Active
- 2018-03-09 AU AU2018201736A patent/AU2018201736B2/en active Active
-
2019
- 2019-04-22 US US16/391,272 patent/US11524046B2/en active Active
- 2019-09-18 IL IL26942619A patent/IL269426A/en unknown
-
2020
- 2020-06-16 AU AU2020204014A patent/AU2020204014A1/en not_active Abandoned
- 2020-08-07 JP JP2020134278A patent/JP2020189860A/ja active Pending
- 2020-10-12 RU RU2020133461A patent/RU2020133461A/ru unknown
-
2022
- 2022-08-18 JP JP2022130371A patent/JP7368018B2/ja active Active
- 2022-11-11 US US18/054,587 patent/US20230277617A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL269426A (en) | Prevention, disruption and treatment of biofilm with bacteriophage lysin | |
IL274832A (en) | Combinations of bacteriophage lysine and antibiotics against gram-positive bacteria | |
IL269797B (en) | Antimicrobial solid surfaces and treatments and methods for their preparation | |
EP3068289A4 (en) | Prevention and treatment of bed exits, falls, and other conditions | |
HK1203449A1 (en) | Azetidinium-containing copolymers and uses thereof | |
EP2934606A4 (en) | STERILIZATION UNITS, SYSTEMS AND METHODS | |
EP2830627A4 (en) | EYE TREATMENT SOLUTIONS, DISTRIBUTION DEVICES AND DISTRIBUTION REINFORCEMENT PROCEDURES | |
IL237068A (en) | 1,3-dioxanomorphides and 1,3-dioxanocodides | |
HK1198921A1 (en) | Antimicrobial compositions comprising dgla, 15-ohepa and/or 15-hetre and methods of use thereof dgla15-ohepa / 15-hetre | |
HK1205166A1 (en) | Polymer, composition and use | |
EP2908794A4 (en) | ANTIBACTERIAL MONOMERS, ANTIBACTERIAL RESINS AND DENTAL COMPOUNDS WITH THE ANTIBACTERIAL RESINS | |
EP2761029A4 (en) | NOVEL BACTERIOPHAGE AND ANTIBACTERIAL COMPOSITION THEREWITH | |
EP2867239A4 (en) | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF DIABETES | |
BR112014027960A2 (pt) | aparelho e unidade de manipulação manual. | |
HK1206348A1 (en) | Cyclohexane-1,2-indene-1,2-imidazol compounds and their use as bace inhibitors -12--12- bace | |
HK1217688A1 (zh) | -氯- 苯基- -茚- -酮及其用途 | |
EP2837627A4 (en) | AMIDOPYRIDINE DERIVATIVE AND USE THEREOF | |
HK1213142A1 (zh) | 分離軸、軸轂組件及其用途 | |
EP2800568A4 (en) | COMPOSITIONS, USE METHOD AND TREATMENT METHOD THEREFOR | |
EP2810684A4 (en) | EMBASE AND CATHETER WITH EMBASE | |
AP2015008726A0 (en) | Low-glycerin-formulations for hiv treatment and prevention | |
AU2012901222A0 (en) | Treatment and prophylaxis | |
HUP1300416A2 (en) | Bacteriophage against mrsa bacteria, its mutant integrase gene and the use thereof | |
EP2915536A4 (en) | ANTICROBREAM AND COMBINATION WITH THE ANTICREMENT | |
EP2944172A4 (en) | AXIS IN TWO PARTS, AXLE-HUB ASSEMBLY AND USE THEREOF |