HK1208030A1 - Novel pyrazine derivatives as cb2 receptor agonists cb2 - Google Patents

Novel pyrazine derivatives as cb2 receptor agonists cb2

Info

Publication number
HK1208030A1
HK1208030A1 HK15108717.8A HK15108717A HK1208030A1 HK 1208030 A1 HK1208030 A1 HK 1208030A1 HK 15108717 A HK15108717 A HK 15108717A HK 1208030 A1 HK1208030 A1 HK 1208030A1
Authority
HK
Hong Kong
Prior art keywords
receptor agonists
pyrazine derivatives
novel pyrazine
novel
derivatives
Prior art date
Application number
HK15108717.8A
Other languages
English (en)
Chinese (zh)
Inventor
巴萊蒂.德瓦蘇祿
尤偉.格雷瑟
馬蒂亞斯.內特科文
斯蒂芬.勒韋爾
馬克.羅杰斯-埃文斯
坦賈.舒爾茲-加施
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1208030A1 publication Critical patent/HK1208030A1/xx

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    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
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    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • AHUMAN NECESSITIES
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    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07ORGANIC CHEMISTRY
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    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07ORGANIC CHEMISTRY
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    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
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  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15108717.8A 2012-12-07 2015-09-08 Novel pyrazine derivatives as cb2 receptor agonists cb2 HK1208030A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12196024 2012-12-07
PCT/EP2013/075444 WO2014086807A1 (en) 2012-12-07 2013-12-04 Novel pyrazine derivatives as cb2 receptor agonists

Publications (1)

Publication Number Publication Date
HK1208030A1 true HK1208030A1 (en) 2016-02-19

Family

ID=47290805

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15108717.8A HK1208030A1 (en) 2012-12-07 2015-09-08 Novel pyrazine derivatives as cb2 receptor agonists cb2

Country Status (33)

Country Link
US (1) US9512141B2 (uk)
EP (1) EP2928882B1 (uk)
JP (1) JP6322646B2 (uk)
KR (1) KR20150092156A (uk)
CN (1) CN104837830B (uk)
AR (1) AR093804A1 (uk)
AU (1) AU2013354115B2 (uk)
BR (1) BR112015009603A2 (uk)
CA (1) CA2885418A1 (uk)
CL (1) CL2015001318A1 (uk)
CR (1) CR20150210A (uk)
CY (1) CY1118808T1 (uk)
DK (1) DK2928882T3 (uk)
EA (1) EA025840B1 (uk)
ES (1) ES2621958T3 (uk)
HK (1) HK1208030A1 (uk)
HR (1) HRP20170572T1 (uk)
HU (1) HUE030836T2 (uk)
IL (1) IL237982A (uk)
IN (1) IN2015DN03145A (uk)
LT (1) LT2928882T (uk)
MA (1) MA38217B1 (uk)
MX (1) MX2015006036A (uk)
PE (1) PE20151060A1 (uk)
PH (1) PH12015501072B1 (uk)
PL (1) PL2928882T3 (uk)
PT (1) PT2928882T (uk)
RS (1) RS55951B1 (uk)
SG (1) SG11201504011UA (uk)
SI (1) SI2928882T1 (uk)
TW (1) TW201427960A (uk)
UA (1) UA116894C2 (uk)
WO (1) WO2014086807A1 (uk)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2629751T3 (es) 2013-03-07 2017-08-14 F. Hoffmann-La Roche Ag Derivados de pirazol novedosos
EA027569B1 (ru) 2013-03-26 2017-08-31 Ф.Хоффманн-Ля Рош Аг Производные пиридина
UA116801C2 (uk) 2013-05-02 2018-05-10 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ ЯК АГОНІСТИ РЕЦЕПТОРА CB2
RS57461B1 (sr) 2013-05-02 2018-09-28 Hoffmann La Roche Derivati purina kao agonisti cb2 receptora
KR20220140651A (ko) 2013-09-06 2022-10-18 에프. 호프만-라 로슈 아게 신규의 트라이아졸로[4,5-d]피리미딘 유도체
SG11201608108SA (en) * 2014-04-04 2016-10-28 Hoffmann La Roche Pyridine-2-amides useful as cb2 agonists
CA2999216A1 (en) 2015-12-09 2017-06-15 F. Hoffmann-La Roche Ag Phenyl derivatives as cannabinoid receptor 2 agonists
WO2018234284A1 (en) 2017-06-20 2018-12-27 F. Hoffmann-La Roche Ag PYRIDINE DERIVATIVES
CN112638430B (zh) 2018-06-27 2023-05-16 豪夫迈·罗氏有限公司 放射性标记的大麻素受体2配体
SG11202009103WA (en) * 2018-06-27 2020-10-29 Hoffmann La Roche Novel pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
WO2020002270A1 (en) 2018-06-27 2020-01-02 F. Hoffmann-La Roche Ag Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
WO2022128050A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammation and pain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629346B2 (en) * 2006-06-19 2009-12-08 Hoffmann-La Roche Inc. Pyrazinecarboxamide derivatives as CB1 antagonists
ES2344128T3 (es) * 2006-10-04 2010-08-18 F. Hoffmann-La Roche Ag Derivados de pirazina-2-carboxamida como moduladores de receptores cb2.
WO2012031817A1 (en) 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Determination of abca1 protein levels in cells
US9321727B2 (en) 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
US9403808B2 (en) * 2011-10-28 2016-08-02 Hoffmann-La Roche Inc. Pyrazine derivatives

Also Published As

Publication number Publication date
EA025840B1 (ru) 2017-02-28
CN104837830A (zh) 2015-08-12
IN2015DN03145A (uk) 2015-10-02
US20150299220A1 (en) 2015-10-22
HUE030836T2 (en) 2017-06-28
KR20150092156A (ko) 2015-08-12
PH12015501072A1 (en) 2015-08-03
EA201590827A1 (ru) 2015-09-30
AU2013354115B2 (en) 2017-10-05
WO2014086807A1 (en) 2014-06-12
ES2621958T3 (es) 2017-07-05
DK2928882T3 (en) 2017-02-20
JP2016505557A (ja) 2016-02-25
PH12015501072B1 (en) 2015-08-03
AR093804A1 (es) 2015-06-24
CA2885418A1 (en) 2014-06-12
RS55951B1 (sr) 2017-09-29
AU2013354115A1 (en) 2015-04-09
MA38217A1 (fr) 2017-02-28
CN104837830B (zh) 2018-07-20
SG11201504011UA (en) 2015-07-30
JP6322646B2 (ja) 2018-05-09
CR20150210A (es) 2015-05-29
EP2928882A1 (en) 2015-10-14
US9512141B2 (en) 2016-12-06
MA38217B1 (fr) 2017-11-30
SI2928882T1 (sl) 2017-05-31
BR112015009603A2 (pt) 2017-07-04
CL2015001318A1 (es) 2015-10-02
HRP20170572T1 (hr) 2017-06-16
PL2928882T3 (pl) 2017-07-31
MX2015006036A (es) 2015-08-07
PE20151060A1 (es) 2015-07-25
LT2928882T (lt) 2017-03-27
IL237982A (en) 2017-06-29
EP2928882B1 (en) 2017-01-18
TW201427960A (zh) 2014-07-16
CY1118808T1 (el) 2018-01-10
PT2928882T (pt) 2017-03-16
UA116894C2 (uk) 2018-05-25

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