HK1207382A1 - Methods for the synthesis of ethylfumarates and their use as intermediates - Google Patents

Methods for the synthesis of ethylfumarates and their use as intermediates Download PDF

Info

Publication number
HK1207382A1
HK1207382A1 HK15108108.5A HK15108108A HK1207382A1 HK 1207382 A1 HK1207382 A1 HK 1207382A1 HK 15108108 A HK15108108 A HK 15108108A HK 1207382 A1 HK1207382 A1 HK 1207382A1
Authority
HK
Hong Kong
Prior art keywords
reaction
diketopiperazine
activated
fumarate
yield
Prior art date
Application number
HK15108108.5A
Other languages
English (en)
Chinese (zh)
Inventor
Kelly Kraft
John Freeman
Paul SERWINSKI
Vinnie PAVIA
Otto PHANTSIEL
Navneet Kaur
Original Assignee
Mannkind, Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind, Corp filed Critical Mannkind, Corp
Publication of HK1207382A1 publication Critical patent/HK1207382A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15108108.5A 2012-04-27 2013-03-15 Methods for the synthesis of ethylfumarates and their use as intermediates HK1207382A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261639536P 2012-04-27 2012-04-27
US61/639536 2012-04-27
PCT/US2013/032162 WO2013162764A1 (en) 2012-04-27 2013-03-15 Methods for the synthesis of ethylfumarates and their use as intermediates

Publications (1)

Publication Number Publication Date
HK1207382A1 true HK1207382A1 (en) 2016-01-29

Family

ID=49477848

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15108108.5A HK1207382A1 (en) 2012-04-27 2013-03-15 Methods for the synthesis of ethylfumarates and their use as intermediates

Country Status (16)

Country Link
US (6) US9193691B2 (cs)
EP (1) EP2841422B1 (cs)
JP (1) JP6241682B2 (cs)
KR (1) KR20150023315A (cs)
CN (2) CN107879938A (cs)
AU (2) AU2013252901B2 (cs)
BR (1) BR112014026809A2 (cs)
CA (1) CA2871126C (cs)
HK (1) HK1207382A1 (cs)
IL (1) IL235247A0 (cs)
IN (1) IN2014DN09774A (cs)
MX (1) MX361470B (cs)
RU (1) RU2014143116A (cs)
SG (1) SG11201406970QA (cs)
WO (1) WO2013162764A1 (cs)
ZA (1) ZA201408429B (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ES2425392T3 (es) 2002-03-20 2013-10-15 Mannkind Corporation Cartucho para un aparato de inhalación
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
PL2322180T3 (pl) 2004-08-23 2015-10-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
CN104324366B (zh) 2005-09-14 2016-10-05 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
KR20180079458A (ko) 2009-06-12 2018-07-10 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
BR112014026809A2 (pt) * 2012-04-27 2017-06-27 Mannkind Corp métodos para a síntese de etilfumaratos ativados e seu uso como intermediários
SG10201605800UA (en) 2012-07-12 2016-09-29 Mannkind Corp Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
KR102465025B1 (ko) 2013-07-18 2022-11-09 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN117646042B (zh) * 2023-11-13 2025-04-11 浙江工业大学 一种富马酸单酯的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407203A (en) 1965-03-22 1968-10-22 Union Carbide Corp Novel process for the preparation of diketopiperazines
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
DE10019879A1 (de) 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
PL2322180T3 (pl) 2004-08-23 2015-10-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
KR20080096809A (ko) * 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
JP5788806B2 (ja) * 2008-12-29 2015-10-07 マンカインド コーポレイション 薬物送達剤用置換ジケトピペラジン及びその塩、これらを含む治療用組成物、微粒子組成物及び乾燥粉末組成物、並びに、その調整方法
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2427430B1 (en) * 2009-05-04 2014-09-10 The Royal Institution for the Advancement of Learning/McGill University 5-oxo-ete receptor antagonist compounds
CN101851213A (zh) * 2010-06-21 2010-10-06 于清 3，6-双(4-双反丁烯二酰基氨丁基)-2，5-二酮哌嗪及其盐取代物的合成方法
CN103534242B (zh) 2011-02-10 2016-04-20 曼坎德公司 N-保护的双-3,6-(4-氨基烷基)-2,5-二酮哌嗪的形成
BR112014026809A2 (pt) * 2012-04-27 2017-06-27 Mannkind Corp métodos para a síntese de etilfumaratos ativados e seu uso como intermediários

Also Published As

Publication number Publication date
EP2841422B1 (en) 2019-08-28
US10858325B2 (en) 2020-12-08
US20190010131A1 (en) 2019-01-10
US20210114994A1 (en) 2021-04-22
AU2018201397A1 (en) 2018-03-22
US9193691B2 (en) 2015-11-24
EP2841422A4 (en) 2016-04-13
BR112014026809A2 (pt) 2017-06-27
AU2013252901A1 (en) 2014-11-06
EP2841422A1 (en) 2015-03-04
CA2871126C (en) 2020-07-14
AU2013252901B2 (en) 2017-11-30
SG11201406970QA (en) 2014-11-27
MX2014013075A (es) 2015-08-14
WO2013162764A1 (en) 2013-10-31
ZA201408429B (en) 2021-05-26
US20230057608A1 (en) 2023-02-23
IN2014DN09774A (cs) 2015-07-31
CA2871126A1 (en) 2013-10-31
US10071969B2 (en) 2018-09-11
US20250109109A1 (en) 2025-04-03
AU2018201397B2 (en) 2019-05-02
US20130289278A1 (en) 2013-10-31
RU2014143116A (ru) 2016-06-20
US11479535B2 (en) 2022-10-25
CN104797563B (zh) 2017-12-15
CN104797563A (zh) 2015-07-22
US20160159753A1 (en) 2016-06-09
CN107879938A (zh) 2018-04-06
IL235247A0 (en) 2014-12-31
JP2015519321A (ja) 2015-07-09
JP6241682B2 (ja) 2017-12-06
MX361470B (es) 2018-12-06
US12202807B2 (en) 2025-01-21
KR20150023315A (ko) 2015-03-05

Similar Documents

Publication Publication Date Title
HK1207382A1 (en) Methods for the synthesis of ethylfumarates and their use as intermediates
CN101346355B (zh) 制备4-（苯并咪唑基甲基氨基）-苯甲脒的盐的改良方法
US7214702B2 (en) Process for producing a dipeptidyl peptidase IV inhibitor
CN102993102B (zh) [1-甲基-2-(7’-庚异羟肟酸基)-5-n，n-二(2’-氯乙基)]-1h-苯并咪唑的合成方法
EP4212509B1 (en) Method for preparing water-soluble magnolol derivative and honokiol derivative, methods for preparing intermediates of water-soluble magnolol derivative and honokiol derivative, and related monohydroxy protected intermediate
HUT74935A (en) Novel high enantio-selective process for producing pure enantiomeric cyclopentane and cyclopentene-beta-amino acids
JP2018090551A (ja) Ｌ−カルノシン誘導体またはその塩、及びｌ−カルノシンまたはその塩の製造方法
WO2020134727A1 (zh) 一种四肽化合物及制备方法和用途
WO2022083728A1 (zh) 一种普瑞巴林的中间体及其制备方法
US7858779B2 (en) Process for preparing oxcarbazepine
CN111333513B (zh) 一种2,4-二氟-3-硝基苯甲酸的制备方法
EP4043439A1 (en) An improved process for the synthesis of ivacaftor [
JP2019167317A (ja) Ｌ−カルノシン誘導体及びｌ−カルノシンの製造方法
HK40088053B (en) Method for preparing water-soluble magnolol derivative and honokiol derivative, methods for preparing intermediates of water-soluble magnolol derivative and honokiol derivative, and related monohydroxy protected intermediate
HK40088053A (en) Method for preparing water-soluble magnolol derivative and honokiol derivative, methods for preparing intermediates of water-soluble magnolol derivative and honokiol derivative, and related monohydroxy protected intermediate
US20130317235A1 (en) Process for the preparation of (1s, 3s, 5s)-2-[2(s)-2-amino-2-(3-hydroxy-1-adamantan-1-yl acetyl]-2-azabicyclo [3.1.0] hexane-3-carbonitrile
JP2009221122A (ja) 蛍光誘導体の製造方法
HK1112911A (en) Method for sulfonating 1,2-benzisoxazole-3-acetic acid
EP1935888A1 (en) Method for sulfonating 1,2-benzisoxazole-3-acetic acid