HK1205184A1 - 超家族受體的剪接轉換寡聚物,以及它們治療疾病的用途 - Google Patents

超家族受體的剪接轉換寡聚物,以及它們治療疾病的用途

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Publication number
HK1205184A1
HK1205184A1 HK15105622.8A HK15105622A HK1205184A1 HK 1205184 A1 HK1205184 A1 HK 1205184A1 HK 15105622 A HK15105622 A HK 15105622A HK 1205184 A1 HK1205184 A1 HK 1205184A1
Authority
HK
Hong Kong
Prior art keywords
tnf
treatment
disease
superfamily receptors
splice switching
Prior art date
Application number
HK15105622.8A
Other languages
English (en)
Inventor
亨里克‧奧魯姆
彼得‧
‧薩扎尼
Original Assignee
Santaris Pharma As
Ercole Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2007/010556 external-priority patent/WO2008051306A1/en
Priority claimed from US11/799,117 external-priority patent/US7785834B2/en
Application filed by Santaris Pharma As, Ercole Biotech Inc filed Critical Santaris Pharma As
Publication of HK1205184A1 publication Critical patent/HK1205184A1/zh

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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/33Alteration of splicing

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
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  • Saccharide Compounds (AREA)
HK15105622.8A 2007-05-01 2015-06-15 超家族受體的剪接轉換寡聚物,以及它們治療疾病的用途 HK1205184A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2007/010556 WO2008051306A1 (en) 2006-10-20 2007-05-01 Soluble tnf receptors and their use in treatment of disease
US11/799,117 US7785834B2 (en) 2005-11-10 2007-05-01 Soluble TNF receptors and their use in treatment of disease

Publications (1)

Publication Number Publication Date
HK1205184A1 true HK1205184A1 (zh) 2015-12-11

Family

ID=39929868

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11104796.5A HK1150850A1 (zh) 2007-05-01 2011-05-16 超家族受體的剪接轉換寡聚物,以及它們治療疾病的用途
HK15105622.8A HK1205184A1 (zh) 2007-05-01 2015-06-15 超家族受體的剪接轉換寡聚物,以及它們治療疾病的用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK11104796.5A HK1150850A1 (zh) 2007-05-01 2011-05-16 超家族受體的剪接轉換寡聚物,以及它們治療疾病的用途

Country Status (10)

Country Link
US (1) US20120142759A1 (zh)
EP (1) EP2147103B1 (zh)
JP (2) JP2010524476A (zh)
KR (5) KR20180082646A (zh)
CN (2) CN104278033A (zh)
AU (6) AU2007352163A1 (zh)
CA (4) CA2684724A1 (zh)
HK (2) HK1150850A1 (zh)
MX (2) MX2009011856A (zh)
WO (1) WO2008131807A2 (zh)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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US6784291B2 (en) 2000-05-04 2004-08-31 Avi Biopharma, Inc. Splice-region antisense composition and method
CA2553104A1 (en) 2004-01-23 2005-08-11 Avi Biopharma, Inc. Antisense oligomers and methods for inducing immune tolerance and immunosuppression
WO2006086667A2 (en) 2005-02-09 2006-08-17 Avi Bio Pharma, Inc. Antisense composition and method for treating muscle atrophy
US7785834B2 (en) 2005-11-10 2010-08-31 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
EP4082551A1 (en) 2006-08-08 2022-11-02 Rheinische Friedrich-Wilhelms-Universität Bonn Structure and use of 5' phosphate oligonucleotides
JP5689413B2 (ja) 2008-05-21 2015-03-25 ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン 平滑末端を有する5’三リン酸オリゴヌクレオチドおよびその使用
US9364495B2 (en) 2009-10-20 2016-06-14 Roche Innovation Center Copenhagen A/S Oral delivery of therapeutically effective LNA oligonucleotides
EP2582397A4 (en) * 2010-06-15 2014-10-29 Isis Pharmaceuticals Inc COMPOUNDS AND METHODS FOR MODULATING THE INTERACTION BETWEEN PROTEINS AND TARGET NUCLEIC ACIDS
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
WO2013148260A1 (en) * 2012-03-30 2013-10-03 Washington University Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
EP2906255B1 (en) * 2012-10-12 2023-02-22 Ionis Pharmaceuticals, Inc. Antisense compounds and uses thereof
KR20150083920A (ko) 2012-11-15 2015-07-20 로슈 이노베이션 센터 코펜하겐 에이/에스 항 apob 안티센스 접합체 화합물
KR20150110562A (ko) 2013-01-30 2015-10-02 에프. 호프만-라 로슈 아게 Lna 올리고뉴클레오타이드 탄수화물 컨쥬게이트
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
TWI657819B (zh) 2013-07-19 2019-05-01 美商Ionis製藥公司 用於調節τ蛋白表現之組合物
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
EP3394258B1 (en) 2015-10-22 2021-09-22 Roche Innovation Center Copenhagen A/S In vitro toxicity screening assay
EP3472348B1 (en) 2016-06-17 2022-06-29 F. Hoffmann-La Roche AG In vitro nephrotoxicity screening assay
EP3472347B1 (en) 2016-06-17 2023-01-04 F. Hoffmann-La Roche AG In vitro nephrotoxicity screening assay
JOP20190065A1 (ar) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
EP3339408B1 (en) * 2016-12-22 2020-01-29 The Procter & Gamble Company Fabric softener composition having improved dispensing properties
WO2019032054A1 (en) * 2017-08-11 2019-02-14 Agency For Science, Technology And Research METHOD FOR SCREENING VARIANTS OR SPLICE EVENTS
EP4092117A1 (en) 2017-12-22 2022-11-23 Roche Innovation Center Copenhagen A/S Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
KR20200104345A (ko) 2017-12-22 2020-09-03 로슈 이노베이션 센터 코펜하겐 에이/에스 포스포로디티오에이트 뉴클레오시드간 연결을 포함하는 올리고뉴클레오티드
CN111448316A (zh) 2017-12-22 2020-07-24 罗氏创新中心哥本哈根有限公司 新的硫代亚磷酰胺
EP3620519A1 (en) 2018-09-04 2020-03-11 F. Hoffmann-La Roche AG Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
EP3914232A1 (en) 2019-01-25 2021-12-01 F. Hoffmann-La Roche AG Lipid vesicle for oral drug delivery
KR102470669B1 (ko) * 2022-06-03 2022-11-25 충남대학교 산학협력단 스플라이싱-스위치 올리고뉴클레오티드를 유효성분으로 포함하는 폴리프로모 1 유전자의 스플라이싱 조절용 조성물

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Publication number Priority date Publication date Assignee Title
US6410324B1 (en) * 2001-04-27 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of tumor necrosis factor receptor 2 expression
US6136603A (en) * 1999-03-26 2000-10-24 Isis Pharmaceuticals Inc. Antisense modulation of interleukin-5 signal transduction
CA2477014A1 (en) 2002-02-20 2003-08-28 Sirna Therapeutics, Inc. Rna interference mediated inhibition of tnf and tnf receptor superfamily gene expression using short interfering nucleic acid (sina)
CA2629323A1 (en) * 2005-11-10 2007-05-24 The University Of North Carolina At Chapel Hill Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease
AU2007309650A1 (en) * 2006-02-08 2008-05-02 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
US20090264353A1 (en) * 2007-10-19 2009-10-22 Santaris Pharma A/S Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease

Also Published As

Publication number Publication date
HK1150850A1 (zh) 2012-01-13
KR101738655B1 (ko) 2017-05-22
KR20150139979A (ko) 2015-12-14
AU2019208249A1 (en) 2019-08-15
WO2008131807A2 (en) 2008-11-06
CA2991580A1 (en) 2008-11-06
EP2147103A2 (en) 2010-01-27
KR20170056032A (ko) 2017-05-22
EP2147103B1 (en) 2018-12-12
CN104278033A (zh) 2015-01-14
AU2014203220A1 (en) 2014-07-10
US20120142759A1 (en) 2012-06-07
KR20150036814A (ko) 2015-04-07
JP2010524476A (ja) 2010-07-22
CA3165250A1 (en) 2008-11-06
AU2007352163A1 (en) 2008-11-06
CN101889086A (zh) 2010-11-17
JP2014050400A (ja) 2014-03-20
CA3072221A1 (en) 2008-11-06
AU2018200382A1 (en) 2018-02-08
MX2009011856A (es) 2010-06-23
WO2008131807A3 (en) 2009-02-12
MX346434B (es) 2017-03-21
KR20180082646A (ko) 2018-07-18
CN101889086B (zh) 2014-07-02
CA2684724A1 (en) 2008-11-06
AU2016203220A1 (en) 2016-06-09
KR20100101050A (ko) 2010-09-16
KR101531934B1 (ko) 2015-06-29
AU2021204434A1 (en) 2021-07-29

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