MX346434B - Oligómeros de cambio de empalme de receptores de la superfamilia tnf y su uso en el tratamiento de enfermedades. - Google Patents

Oligómeros de cambio de empalme de receptores de la superfamilia tnf y su uso en el tratamiento de enfermedades.

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Publication number
MX346434B
MX346434B MX2012008375A MX2012008375A MX346434B MX 346434 B MX346434 B MX 346434B MX 2012008375 A MX2012008375 A MX 2012008375A MX 2012008375 A MX2012008375 A MX 2012008375A MX 346434 B MX346434 B MX 346434B
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MX
Mexico
Prior art keywords
treatment
splice switching
disease
ssos
tnf superfamily
Prior art date
Application number
MX2012008375A
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English (en)
Inventor
L Sazani Peter
Orum Henrik
Original Assignee
Santaris Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/799,117 external-priority patent/US7785834B2/en
Priority claimed from PCT/US2007/010556 external-priority patent/WO2008051306A1/en
Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Publication of MX346434B publication Critical patent/MX346434B/es

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Organic Chemistry (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a oligonucleótidos de 12-16 nucleobases de longitud, caracterizado porque comprende una secuencia de nucleobases contigua la cual consiste en la SEQ ID NO: 246 o un oligómero de 16 nucleobases de longitud, que comprende una secuencia de nucleobases contigua la cual consiste de la SEQ ID NO: 244: en donde las letras mayúsculas representan LNA; el sobreíndice "o" representa oxi LNA; el subíndice "s" representa un enlace de fosforotiato; letras minúsculas representan ADN mC representa 5-metilcitosina; y en donde el LNA es beta-D-oxi LNa.
MX2012008375A 2007-05-01 2007-10-19 Oligómeros de cambio de empalme de receptores de la superfamilia tnf y su uso en el tratamiento de enfermedades. MX346434B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/799,117 US7785834B2 (en) 2005-11-10 2007-05-01 Soluble TNF receptors and their use in treatment of disease
PCT/US2007/010556 WO2008051306A1 (en) 2006-10-20 2007-05-01 Soluble tnf receptors and their use in treatment of disease
PCT/EP2007/061211 WO2008131807A2 (en) 2007-05-01 2007-10-19 Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease

Publications (1)

Publication Number Publication Date
MX346434B true MX346434B (es) 2017-03-21

Family

ID=39929868

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012008375A MX346434B (es) 2007-05-01 2007-10-19 Oligómeros de cambio de empalme de receptores de la superfamilia tnf y su uso en el tratamiento de enfermedades.
MX2009011856A MX2009011856A (es) 2007-05-01 2007-10-19 Oligomeros de cambio de division de receptores de la superfamilia tnf y su uso en tratamientos o enfermedades.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2009011856A MX2009011856A (es) 2007-05-01 2007-10-19 Oligomeros de cambio de division de receptores de la superfamilia tnf y su uso en tratamientos o enfermedades.

Country Status (10)

Country Link
US (1) US20120142759A1 (es)
EP (1) EP2147103B1 (es)
JP (2) JP2010524476A (es)
KR (5) KR20180082646A (es)
CN (2) CN104278033A (es)
AU (6) AU2007352163A1 (es)
CA (4) CA3165250A1 (es)
HK (2) HK1150850A1 (es)
MX (2) MX346434B (es)
WO (1) WO2008131807A2 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6784291B2 (en) 2000-05-04 2004-08-31 Avi Biopharma, Inc. Splice-region antisense composition and method
AU2005208710A1 (en) 2004-01-23 2005-08-11 Avi Biopharma, Inc. Antisense oligomers and methods for inducing immune tolerance and immunosuppression
WO2006086667A2 (en) 2005-02-09 2006-08-17 Avi Bio Pharma, Inc. Antisense composition and method for treating muscle atrophy
US7785834B2 (en) 2005-11-10 2010-08-31 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
PT2056845T (pt) 2006-08-08 2017-11-17 Rheinische Friedrich-Wilhelms-Universität Bonn Estrutura e uso de oligonucleótidos com fosfato 5
JP5689413B2 (ja) 2008-05-21 2015-03-25 ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン 平滑末端を有する５’三リン酸オリゴヌクレオチドおよびその使用
WO2011048125A1 (en) 2009-10-20 2011-04-28 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
WO2011159836A2 (en) * 2010-06-15 2011-12-22 Isis Pharmaceuticals, Inc. Compounds and methods for modulating interaction between proteins and target nucleic acids
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
US10273474B2 (en) 2012-03-30 2019-04-30 Washington University Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2014059341A2 (en) * 2012-10-12 2014-04-17 Isis Pharmaceuticals, Inc. Antisense compounds and uses thereof
AU2013346767B2 (en) 2012-11-15 2019-04-11 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugates
DK2951305T3 (en) 2013-01-30 2018-10-29 Hoffmann La Roche LNA oligonucleotide KULHYDRATKONJUGATER
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
TW202246503A (zh) 2013-07-19 2022-12-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
EP3394258B1 (en) 2015-10-22 2021-09-22 Roche Innovation Center Copenhagen A/S In vitro toxicity screening assay
JP7049271B2 (ja) 2016-06-17 2022-04-06 エフ．ホフマン－ラ ロシュ アーゲー インビトロ腎毒性スクリーニングアッセイ
CN109312403B (zh) 2016-06-17 2023-06-27 豪夫迈·罗氏有限公司 体外肾毒性筛选测定法
JOP20190065A1 (ar) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
EP3339408B1 (en) * 2016-12-22 2020-01-29 The Procter & Gamble Company Fabric softener composition having improved dispensing properties
WO2019032054A1 (en) * 2017-08-11 2019-02-14 Agency For Science, Technology And Research METHOD FOR SCREENING VARIANTS OR SPLICE EVENTS
CA3085406A1 (en) 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
EP3728591A1 (en) 2017-12-22 2020-10-28 Roche Innovation Center Copenhagen A/S Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
CN111448316A (zh) 2017-12-22 2020-07-24 罗氏创新中心哥本哈根有限公司 新的硫代亚磷酰胺
EP3620519A1 (en) 2018-09-04 2020-03-11 F. Hoffmann-La Roche AG Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
JP2022518500A (ja) 2019-01-25 2022-03-15 エフ．ホフマン－ラ ロシュ アーゲー 経口薬物送達のための脂質小胞
KR102470669B1 (ko) * 2022-06-03 2022-11-25 충남대학교 산학협력단 스플라이싱-스위치 올리고뉴클레오티드를 유효성분으로 포함하는 폴리프로모 1 유전자의 스플라이싱 조절용 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410324B1 (en) * 2001-04-27 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of tumor necrosis factor receptor 2 expression
US6136603A (en) * 1999-03-26 2000-10-24 Isis Pharmaceuticals Inc. Antisense modulation of interleukin-5 signal transduction
WO2003070897A2 (en) * 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR SUPERFAMILY GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
AU2006315758A1 (en) * 2005-11-10 2007-05-24 Ercole Biotech, Inc. Splice switching oligomers for TNF superfamily receptors and their use in treatment of disease
US20090264353A1 (en) * 2007-10-19 2009-10-22 Santaris Pharma A/S Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease
CA2666981A1 (en) * 2006-10-20 2008-05-02 Ercole Biotech, Inc. Soluble tnf receptors and their use in treatment of disease

Also Published As

Publication number Publication date
JP2010524476A (ja) 2010-07-22
AU2016203220A1 (en) 2016-06-09
HK1205184A1 (en) 2015-12-11
CA3165250A1 (en) 2008-11-06
MX2009011856A (es) 2010-06-23
WO2008131807A3 (en) 2009-02-12
KR101738655B1 (ko) 2017-05-22
AU2014203220A1 (en) 2014-07-10
KR20150139979A (ko) 2015-12-14
EP2147103A2 (en) 2010-01-27
WO2008131807A2 (en) 2008-11-06
CA2684724A1 (en) 2008-11-06
KR20150036814A (ko) 2015-04-07
KR20180082646A (ko) 2018-07-18
US20120142759A1 (en) 2012-06-07
EP2147103B1 (en) 2018-12-12
KR20100101050A (ko) 2010-09-16
CN104278033A (zh) 2015-01-14
AU2007352163A1 (en) 2008-11-06
KR101531934B1 (ko) 2015-06-29
AU2021204434A1 (en) 2021-07-29
CA3072221A1 (en) 2008-11-06
CN101889086B (zh) 2014-07-02
AU2018200382A1 (en) 2018-02-08
KR20170056032A (ko) 2017-05-22
JP2014050400A (ja) 2014-03-20
AU2019208249A1 (en) 2019-08-15
CA2991580A1 (en) 2008-11-06
HK1150850A1 (en) 2012-01-13
CN101889086A (zh) 2010-11-17

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