HK1203958A1 - Sulfonamide compounds and uses as tnap inhibitors tnap - Google Patents
Sulfonamide compounds and uses as tnap inhibitors tnapInfo
- Publication number
- HK1203958A1 HK1203958A1 HK15104653.3A HK15104653A HK1203958A1 HK 1203958 A1 HK1203958 A1 HK 1203958A1 HK 15104653 A HK15104653 A HK 15104653A HK 1203958 A1 HK1203958 A1 HK 1203958A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tnap
- inhibitors
- sulfonamide compounds
- sulfonamide
- compounds
- Prior art date
Links
- -1 Sulfonamide compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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US201261601957P | 2012-02-22 | 2012-02-22 | |
PCT/US2013/027191 WO2013126608A1 (en) | 2012-02-22 | 2013-02-21 | Sulfonamide compounds and uses as tnap inhibitors |
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JP (2) | JP6302846B2 (xx) |
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CN (1) | CN104334527B (xx) |
AU (1) | AU2013222345B2 (xx) |
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CA (1) | CA2865071C (xx) |
HK (1) | HK1203958A1 (xx) |
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BR112013004685B1 (pt) | 2010-09-01 | 2021-09-21 | Thomas Jefferson University | Uso de um agonista de receptor gama de ácido retinóico (rar?) para reparação e regeneração muscular |
KR102083041B1 (ko) | 2012-02-22 | 2020-05-27 | 샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트 | 술폰아미드 화합물 및 tnap 억제제로서 용도 |
SG11201604820XA (en) | 2014-01-14 | 2016-07-28 | Millennium Pharm Inc | Heteroaryls and uses thereof |
EP3094326A4 (en) | 2014-01-14 | 2017-07-26 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
CN103755628B (zh) * | 2014-01-27 | 2015-07-29 | 河北科技大学 | 2-氨基-3-碘-5-溴吡啶的合成方法 |
WO2016054056A1 (en) * | 2014-10-01 | 2016-04-07 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Methods of treating pxe with tnap inhibitors |
EP3319970B1 (en) | 2015-07-08 | 2019-08-28 | Daiichi Sankyo Company, Limited | Pyrido-oxazinone derivatives as tnap inhibitors |
ITUA20161994A1 (it) * | 2016-03-24 | 2017-09-24 | Azienda Ospedaliera Univ Senese | Uso degli inibitori ddx3 come agenti anti-iperproliferativi |
ES2963348T3 (es) | 2016-06-08 | 2024-03-26 | Clementia Pharmaceuticals Inc | Métodos para tratar la osificación heterotópica |
CN110167946B (zh) * | 2016-12-23 | 2022-04-08 | 第一三共株式会社 | 具有tnap抑制活性的磺酰胺化合物 |
WO2018119449A1 (en) | 2016-12-23 | 2018-06-28 | Daiichi Sankyo Company, Limited | Oxazepine derivatives having tnap inhibitory activity |
WO2020014330A1 (en) * | 2018-07-10 | 2020-01-16 | Academia Sinica | A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis |
WO2020086504A1 (en) | 2018-10-23 | 2020-04-30 | Daiichi Sankyo Company, Limited | Biaryl derivative |
BR112022010908A2 (pt) | 2019-12-04 | 2022-09-06 | Univ Leland Stanford Junior | Métodos para aumentar a permeabilidade da barreira hematoencefálica, para distribuir um agente terapêutico ao cérebro e para identificar uma biomolécula que regula a permeabilidade da barreira hematoencefálica em um sujeito |
CN113683563B (zh) * | 2021-08-31 | 2024-01-30 | 合肥工业大学 | 一种多取代3-磺酰胺喹啉化合物的合成方法 |
CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院(深圳福田) | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
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JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
EP1258252B1 (en) * | 2000-02-03 | 2010-04-21 | Eisai R&D Management Co., Ltd. | Integrin expression inhibitors |
AU2002346620A1 (en) * | 2001-11-30 | 2003-06-17 | Department Of Veteran Affairs | Induction of apoptosis in cancer cells |
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US20040142981A1 (en) * | 2002-08-23 | 2004-07-22 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
US20040110802A1 (en) * | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
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WO2006039480A2 (en) * | 2004-09-29 | 2006-04-13 | The Burnham Institute For Medical Research | Tissue non-specific alkaline phosphate (tnap): a therapeutic target for arterial calcification |
SE0402735D0 (sv) * | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
GB0425026D0 (en) * | 2004-11-12 | 2004-12-15 | Biofocus Discovery Ltd | Compounds which bind to the active site of protein kinase enzymes |
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US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
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WO2010130638A1 (en) * | 2009-05-14 | 2010-11-18 | Evotec Ag | Sulfonamide compounds, pharmaceutical compositions and uses thereof |
BRPI1010600A2 (pt) * | 2009-05-15 | 2016-03-15 | Novartis Ag | aril piridina como inibidores de aldosterona sintase |
CN102481300B (zh) * | 2009-06-29 | 2015-04-15 | 安吉奥斯医药品有限公司 | 治疗性化合物和组合物 |
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WO2016054056A1 (en) * | 2014-10-01 | 2016-04-07 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Methods of treating pxe with tnap inhibitors |
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2013
- 2013-02-21 KR KR1020147025901A patent/KR102083041B1/ko active IP Right Grant
- 2013-02-21 CN CN201380021207.0A patent/CN104334527B/zh active Active
- 2013-02-21 RU RU2014137402A patent/RU2627701C2/ru active
- 2013-02-21 WO PCT/US2013/027191 patent/WO2013126608A1/en active Application Filing
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- 2013-02-21 BR BR112014020773-9A patent/BR112014020773A2/pt not_active Application Discontinuation
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2015
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2016
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2018
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- 2018-02-05 US US15/888,736 patent/US10370333B2/en active Active
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US9884826B2 (en) | 2018-02-06 |
KR102083041B1 (ko) | 2020-05-27 |
JP2018104434A (ja) | 2018-07-05 |
JP6302846B2 (ja) | 2018-03-28 |
US20190010126A1 (en) | 2019-01-10 |
EP2817292B1 (en) | 2019-12-18 |
KR20140129191A (ko) | 2014-11-06 |
BR112014020773A2 (pt) | 2020-10-27 |
JP6544545B2 (ja) | 2019-07-17 |
JP2015508102A (ja) | 2015-03-16 |
US9458147B2 (en) | 2016-10-04 |
EP2817292A4 (en) | 2015-08-26 |
CA2865071A1 (en) | 2013-08-29 |
US20150011551A1 (en) | 2015-01-08 |
RU2627701C2 (ru) | 2017-08-10 |
WO2013126608A1 (en) | 2013-08-29 |
CA2865071C (en) | 2020-06-23 |
US10370333B2 (en) | 2019-08-06 |
US20160355479A1 (en) | 2016-12-08 |
CN104334527A (zh) | 2015-02-04 |
AU2013222345A1 (en) | 2014-09-11 |
EP2817292A1 (en) | 2014-12-31 |
RU2014137402A (ru) | 2016-04-10 |
CN104334527B (zh) | 2017-05-24 |
AU2013222345B2 (en) | 2017-09-07 |
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