HK1202583A1 - Populations of hematopoietic progenitors and methods of enriching stem cells therefor - Google Patents

Populations of hematopoietic progenitors and methods of enriching stem cells therefor

Info

Publication number
HK1202583A1
HK1202583A1 HK15103113.9A HK15103113A HK1202583A1 HK 1202583 A1 HK1202583 A1 HK 1202583A1 HK 15103113 A HK15103113 A HK 15103113A HK 1202583 A1 HK1202583 A1 HK 1202583A1
Authority
HK
Hong Kong
Prior art keywords
populations
methods
stem cells
hematopoietic progenitors
cells therefor
Prior art date
Application number
HK15103113.9A
Other languages
English (en)
Chinese (zh)
Inventor
Gordon Keller
Juan Carlos Zuniga-Pflucker
Marion J Kennedy
Christopher Michael Sturgeon
Andrea Ditadi
Geneve Sheandra Awong
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Publication of HK1202583A1 publication Critical patent/HK1202583A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/35—Polyols, e.g. glycerin, inositol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/14—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2303—Interleukin-3 (IL-3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2311—Interleukin-11 (IL-11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK15103113.9A 2011-11-21 2015-03-27 Populations of hematopoietic progenitors and methods of enriching stem cells therefor HK1202583A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161562094P 2011-11-21 2011-11-21
PCT/CA2012/001076 WO2013075222A1 (fr) 2011-11-21 2012-11-21 Populations de progéniteurs hématopoïétiques et procédés d'enrichissement de cellules souches associé en ceux-ci

Publications (1)

Publication Number Publication Date
HK1202583A1 true HK1202583A1 (en) 2015-10-02

Family

ID=48468944

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103113.9A HK1202583A1 (en) 2011-11-21 2015-03-27 Populations of hematopoietic progenitors and methods of enriching stem cells therefor

Country Status (9)

Country Link
US (1) US9834754B2 (fr)
EP (1) EP2782996B1 (fr)
JP (5) JP6344821B2 (fr)
CN (2) CN110241083A (fr)
AU (3) AU2012324017A1 (fr)
CA (1) CA2856322C (fr)
HK (1) HK1202583A1 (fr)
SG (2) SG10201709546YA (fr)
WO (1) WO2013075222A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016537337A (ja) 2013-11-13 2016-12-01 コーネル ユニヴァーシティ 生後の造血内皮細胞ならびにそれらの単離および使用
WO2015167226A1 (fr) * 2014-04-29 2015-11-05 국립암센터 Cellules souches dérivées du système har-nds, procédé pour les séparer, et utilisation
CA2974381A1 (fr) * 2015-01-26 2016-08-04 Fate Therapeutics, Inc. Procedes et compositions pour induire la differenciation de cellules hematopoietiques
WO2016127259A1 (fr) 2015-02-11 2016-08-18 The Hospital For Sick Children Macrophages de type alvéolaire et leur procédé de production
CN105316293A (zh) * 2015-09-23 2016-02-10 广东颐养抗衰老研究院 一种体外获得造血干/祖细胞的方法
DK3365435T3 (da) 2015-10-20 2021-04-06 Fujifilm Cellular Dynamics Inc Produktion af hæmatopoietiske prækursorceller med multi-afstamning med genetisk programmering
ES2953925T3 (es) 2015-11-04 2023-11-17 Fate Therapeutics Inc Ingeniería genómica de células pluripotentes
EP3371301A4 (fr) 2015-11-04 2019-06-26 Fate Therapeutics, Inc. Procédés et compositions pour induire la différenciation de cellules hématopoïétiques
WO2018048828A1 (fr) 2016-09-06 2018-03-15 The Children's Medical Center Corporation Cellules immunitaires dérivées de cellules souches pluripotentes induites
AU2017340634B2 (en) 2016-10-05 2022-06-02 FUJIFILM Cellular Dynamics, Inc. Generating mature lineages from induced pluripotent stem cells with MECP2 disruption
EP3578650A4 (fr) 2017-02-06 2021-03-24 National Cancer Center Japan Nouveau récepteur des lymphocytes t
EP3617307A4 (fr) * 2017-04-26 2021-01-27 Kyoto University Marqueur de cellules progénitrices hématopoïétiques
JP2021514185A (ja) * 2018-02-14 2021-06-10 サニーブルック リサーチ インスティチュート Ｔ細胞系列の細胞を発生させるための方法
EP3822342A4 (fr) 2018-07-13 2022-08-03 Kyoto University Procédé de production de lymphocytes gamma delta t
JP7382603B2 (ja) 2018-08-10 2023-11-17 国立大学法人京都大学 Ｃｄ３陽性細胞の製造方法
SG11202104197PA (en) * 2018-10-24 2021-05-28 Hebecell Corp Methods and systems for manufacturing hematopoietic lineage cells
CN113207297B (zh) * 2018-12-20 2024-09-24 住友化学株式会社 包含胚胎型成红细胞的细胞群体及其制备方法、细胞培养组合物以及化合物试验方法
WO2020138256A1 (fr) 2018-12-27 2020-07-02 国立大学法人京都大学 Objet modifié par un récepteur de lymphocytes t
WO2020154412A1 (fr) * 2019-01-22 2020-07-30 Washington University Compositions et procédés de génération de cellules souches hématopoïétiques (csh)
US20220252575A1 (en) 2019-03-29 2022-08-11 Public University Corporation Yokohama City University Screening method and toxicity evaluation method
CN113646424A (zh) * 2019-03-29 2021-11-12 富士胶片株式会社 具有分化成特定细胞的能力的多能干细胞的制造方法及其应用
RU2722669C1 (ru) * 2019-07-01 2020-06-02 Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ - ИМБП РАН) Способ получения ассоциатов гемопоэтических и стромальных клеток-предшественников, способных подавлять активацию и пролиферацию аллогенных лимфоцитов
IL293189A (en) 2019-11-25 2022-07-01 Univ Kyoto A primary cell bank of t cells
KR20220130158A (ko) 2020-01-23 2022-09-26 더 칠드런스 메디칼 센터 코포레이션 인간 만능 줄기 세포로부터의 무-간질 t 세포 분화
CN113552363B (zh) * 2020-04-03 2024-03-08 中国科学院广州生物医药与健康研究院 Cd44作为造血干/祖细胞的标志物及其应用
EP4251741A1 (fr) 2020-11-30 2023-10-04 CRISPR Therapeutics AG Cellules tueuses naturelles génétiquement modifiées
EP4271798A1 (fr) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions et procédés de différenciation de cellules souches en cellules nk
WO2023210661A1 (fr) * 2022-04-25 2023-11-02 国立大学法人金沢大学 COMPOSITION POUR RÉGULER L'ACTIVATION DES CELLULES CAR-T, LA PROLIFÉRATION DES CELLULES SOUCHES HÉMATOPOÏÉTIQUES ET LA DIFFÉRENCIATION DES CELLULES iPS, ET SON UTILISATION
WO2023247722A1 (fr) * 2022-06-22 2023-12-28 Fondazione Telethon Ets Procédé d'isolement de cellules endothéliales hémogéniques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0503918D0 (en) * 2005-02-25 2005-04-06 Erasmus University Cell
JP2009506770A (ja) * 2005-09-02 2009-02-19 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 前駆細胞株の誘導法
CN102388130B (zh) * 2009-02-27 2014-08-27 细胞动力国际有限公司 多能细胞的分化

Also Published As

Publication number Publication date
JP2017104129A (ja) 2017-06-15
EP2782996A1 (fr) 2014-10-01
CN110241083A (zh) 2019-09-17
US9834754B2 (en) 2017-12-05
JP2023029655A (ja) 2023-03-03
SG11201402502RA (en) 2015-01-29
EP2782996A4 (fr) 2015-04-08
CN104053769A (zh) 2014-09-17
CA2856322A1 (fr) 2013-05-30
AU2018202355B2 (en) 2019-07-25
AU2016222344A1 (en) 2016-09-22
JP2019136045A (ja) 2019-08-22
JP6344821B2 (ja) 2018-06-20
WO2013075222A1 (fr) 2013-05-30
JP2014533494A (ja) 2014-12-15
CA2856322C (fr) 2021-10-12
EP2782996B1 (fr) 2019-03-27
AU2018202355A1 (en) 2018-04-26
SG10201709546YA (en) 2017-12-28
US20140322808A1 (en) 2014-10-30
AU2012324017A1 (en) 2013-06-06
JP2021100436A (ja) 2021-07-08

Similar Documents

Publication Publication Date Title
HK1202583A1 (en) Populations of hematopoietic progenitors and methods of enriching stem cells therefor
HK1203081A1 (en) Compositions and methods for enhanced generation of hematopoietic stem progenitor cells
EP2744905A4 (fr) Procédés et compositions pour introduire un arndb exogène dans des cellules végétales
HK1198262A1 (en) Measuring volume and constituents of cells
ZA201400141B (en) Keto-isovalerate decarboxylase enzymes and methods of use thereof
IL236672A0 (en) System and methods for preparing vegetable cells from animal fats
IL232450B (en) Methods for distinguishing between stem cells, cell populations of sorted extracorporeal cells and preparations containing them, and uses of these preparations
EP2691512A4 (fr) Populations enrichies de cellules de lignée cardiomyocytaire issues de cellules souches pluripotentes
SG10201802390XA (en) Methods of differentiating stem cells into one or more cell lineages
EP2811011A4 (fr) Nécessaire de culture cellulaire et son procédé d'utilisation
EP2710139A4 (fr) Analyse et tri de cellules motiles
EP2671945A4 (fr) Procédé de culture de cellules souches pluripotentes humaines
IL227919A0 (en) Methods and preparations for the production of stem cells related to highly active nerve cells specific to the patient
PL2686421T3 (pl) Generowanie komórek nk i progenitorów komórek nk
IL240871B (en) Preparations and methods for obtaining cell cultures from tens of mesenchymal stem cells
SG11201401188QA (en) Method for producing megakaryocytes and/or platelets from pluripotent stem cells
EP2723851A4 (fr) Lignées de progéniteurs endodermiques à auto-renouvellement générées à partir de cellules souches pluripotentes humaines et leurs procédés d'utilisation
EP2900808A4 (fr) Procédés de différenciation de cellules souches en chondrocytes
EP2606123A4 (fr) Procédés de générations d'oligodentrocytes et de populations cellulaires les comprenant
EP2698365B8 (fr) Synthèse et analyse de nouveau composé apte à induire la différenciation de cellule souche mésenchymateuse humaine en hépatocyte
GB2500161B (en) Enhancement of allogeneic hematopoietic stem cell transplantation
HK1198122A1 (en) Eosinophil peroxidase compositions and methods of their use
EP2729486A4 (fr) Ligands de ciblage de cellules souches leucémiques et méthodes d'utilisation
IL229462B (en) Formulation and method for transferring and harvesting human stem cells that can develop in different directions
SG11201406622UA (en) An in vitro method for culturing stem cells