SG10201802390XA - Methods of differentiating stem cells into one or more cell lineages - Google Patents
Methods of differentiating stem cells into one or more cell lineagesInfo
- Publication number
- SG10201802390XA SG10201802390XA SG10201802390XA SG10201802390XA SG10201802390XA SG 10201802390X A SG10201802390X A SG 10201802390XA SG 10201802390X A SG10201802390X A SG 10201802390XA SG 10201802390X A SG10201802390X A SG 10201802390XA SG 10201802390X A SG10201802390X A SG 10201802390XA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- stem cells
- cell lineages
- differentiating stem
- differentiating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG2012078325 | 2012-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201802390XA true SG10201802390XA (en) | 2018-05-30 |
Family
ID=54292965
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201802390XA SG10201802390XA (en) | 2012-10-19 | 2013-10-21 | Methods of differentiating stem cells into one or more cell lineages |
SG11201503045YA SG11201503045YA (en) | 2012-10-19 | 2013-10-21 | Methods of differentiating stem cells into one or more cell lineages |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201503045YA SG11201503045YA (en) | 2012-10-19 | 2013-10-21 | Methods of differentiating stem cells into one or more cell lineages |
Country Status (6)
Country | Link |
---|---|
US (1) | US20150329821A1 (en) |
EP (1) | EP2909312A4 (en) |
JP (1) | JP6494515B2 (en) |
CN (1) | CN104995294A (en) |
SG (2) | SG10201802390XA (en) |
WO (1) | WO2014062138A1 (en) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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US10240126B2 (en) * | 2013-06-12 | 2019-03-26 | Kyoto University | Induced pluripotent stem cell selection method and method for inducing differentiation to blood cells |
CA2943035A1 (en) * | 2014-05-06 | 2015-11-12 | F. Hoffmann-La Roche Ag | Method for differentiation of pluripotent stem cells into cardiomyocytes |
CN106795487B (en) * | 2014-08-04 | 2021-11-19 | 武田药品工业株式会社 | Method for proliferating pancreatic progenitor cells |
EP3194569A4 (en) * | 2014-09-19 | 2018-03-07 | Agency For Science, Technology And Research | Differentiation of hepatocyte-like cells from stem cells |
US20170304369A1 (en) * | 2014-10-08 | 2017-10-26 | Agency For Science, Technology And Research | Methods of differentiating stem cells into liver cell lineages |
US10626372B1 (en) | 2015-01-26 | 2020-04-21 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
US10787640B2 (en) | 2015-03-03 | 2020-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Producing mesodermal cell types and methods of using the same |
US20180058987A1 (en) * | 2015-03-23 | 2018-03-01 | New York University | Systems and methods for selecting cellular strains |
EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
CN108368520B (en) | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | Genome engineering of pluripotent cells |
US10858628B2 (en) | 2015-11-04 | 2020-12-08 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
CN105441381B (en) * | 2015-12-31 | 2019-03-05 | 四川大学 | Method of the external evoked human adipose mesenchymal stem cells to functional hepatocyte differentiation |
CN105688968A (en) * | 2016-01-20 | 2016-06-22 | 陕西科技大学 | Bismuth vanadate/boron nitride composite photocatalytic material and preparation method thereof |
CN106987555B (en) * | 2016-01-20 | 2021-10-19 | 中国科学院上海营养与健康研究所 | Small molecule compound composition for efficiently inducing differentiation of human pluripotent stem cells to myocardial cells |
CA3013054A1 (en) * | 2016-01-27 | 2017-08-03 | Memorial Sloan-Kettering Cancer Center | Differentiation of cortical neurons from human pluripotent stem cells |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
EP3423069A4 (en) * | 2016-03-02 | 2020-04-08 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgf-beta inhibition |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
JP7080179B2 (en) | 2016-03-15 | 2022-06-03 | ザ チルドレンズ メディカル センター コーポレーション | Methods and Compositions for Hematopoietic Stem Cell Growth |
WO2017170328A1 (en) * | 2016-03-31 | 2017-10-05 | 学校法人慶應義塾 | Differentiation-promoted pluripotent stem cell and use thereof |
JP7201223B2 (en) * | 2016-04-08 | 2023-01-10 | 国立大学法人京都大学 | Method for selectively inducing endoderm cells from pluripotent stem cells |
MA45479A (en) * | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN ENDODERMAL CELLS OF MIDDLE INTESTINE |
CA3033381A1 (en) * | 2016-08-10 | 2018-02-15 | Indiana University Research And Technology Corporation | Method for generating mesoderm and/or endothelial colony forming cell-like cells having in vivo blood vessel forming capacity |
WO2018101466A1 (en) | 2016-12-02 | 2018-06-07 | タカラバイオ株式会社 | Method for producing endothelial cells |
AU2017373767B2 (en) | 2016-12-05 | 2021-09-16 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
US20200140826A1 (en) * | 2017-01-17 | 2020-05-07 | Agency For Science, Research And Technology | Maintenance and Expansion of Pancreatic Progenitor Cells |
KR102448428B1 (en) * | 2017-01-27 | 2022-09-30 | 가부시키가이샤 가네카 | A method for preparing a population of cells of any one of the three germ layers from a population of endoderm cells, and pluripotent cells |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
CN109112104B (en) * | 2017-06-26 | 2022-08-02 | 深圳华大生命科学研究院 | Culture medium and culture method for differentiation of ESC to ectodermal precursor cells |
EP3679124A1 (en) * | 2017-09-07 | 2020-07-15 | Stemonix Inc. | Efficient differentiation of human stem cells to definitive endoderm |
IL274436B2 (en) * | 2017-11-15 | 2024-01-01 | Semma Therapeutics Inc | Islet cell manufacturing compositions and methods of use |
AU2019273134A1 (en) * | 2018-05-25 | 2020-12-03 | Morphocell Technologies Inc. | Process for making cell populations of the hepatic lineage from endodermal cells and cellular compositions comprising same |
EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
WO2020037323A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
CN111500525B (en) * | 2019-01-30 | 2023-05-02 | 中国科学院广州生物医药与健康研究院 | Composition and application thereof |
EP3972990A4 (en) * | 2019-05-22 | 2023-10-11 | The Cleveland Clinic Foundation | Generating dorsal foregut, and anterior domain, endoderm cells |
US11655449B2 (en) * | 2019-06-03 | 2023-05-23 | Board Of Regents, The University Of Texas System | Culture conditions to prolong/enhanced endodermal cell type for cell transplantation |
US20220275341A1 (en) * | 2019-08-28 | 2022-09-01 | Children's Hospital Medical Center | Organoid mesoderm lineage diversification |
JP2023528665A (en) | 2020-06-09 | 2023-07-05 | ジェネトン | Treatment of dilated cardiomyopathy |
KR20230044455A (en) * | 2020-07-30 | 2023-04-04 | 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 | Bladder organoids and methods for their preparation |
CN112553145B (en) * | 2020-12-25 | 2024-04-02 | 汕头大学医学院 | Efficient induced differentiation method for definitive endoderm cells |
CN112680405B (en) * | 2021-01-19 | 2022-05-10 | 中山大学 | Human endoderm differentiation medium and culture method |
AU2022366819A1 (en) * | 2021-10-15 | 2024-05-02 | Thymmune Therapeutics, Inc. | Thymic cells and methods of making |
CN114149961B (en) * | 2022-02-09 | 2022-04-22 | 天九再生医学(天津)科技有限公司 | Multi-lineage liver organoid and construction method and application thereof |
WO2023240248A2 (en) | 2022-06-09 | 2023-12-14 | Umoja Biopharma, Inc. | Compositions and methods for nk cell differentiation |
WO2024026391A1 (en) | 2022-07-27 | 2024-02-01 | Umoja Biopharma, Inc. | Differentiation of stem cells in suspension culture |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060003446A1 (en) * | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
CA2549605C (en) * | 2003-12-23 | 2013-05-07 | Cythera, Inc. | Definitive endoderm |
CA2576872C (en) * | 2004-08-13 | 2013-11-12 | University Of Georgia Research Foundation, Inc. | Compositions and methods for self-renewal and differentiation in human embryonic stem cells |
CA2654196A1 (en) * | 2006-06-02 | 2007-12-13 | University Of Georgia Research Foundation, Inc. | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
US8642334B2 (en) * | 2009-02-17 | 2014-02-04 | Memorial Sloan Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
EP2233566A1 (en) * | 2009-03-17 | 2010-09-29 | Vrije Universiteit Brussel | Generation of pancreatic progenitor cells |
KR101755214B1 (en) * | 2009-08-12 | 2017-07-07 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
EP2563908B1 (en) * | 2010-04-25 | 2019-01-09 | Icahn School of Medicine at Mount Sinai | Generation of anterior foregut endoderm from pluripotent cells |
US20120152093A1 (en) * | 2010-10-12 | 2012-06-21 | George Koumbis | Assembly and noise suppressor for firearms |
-
2013
- 2013-10-21 US US14/437,147 patent/US20150329821A1/en not_active Abandoned
- 2013-10-21 JP JP2015537668A patent/JP6494515B2/en active Active
- 2013-10-21 SG SG10201802390XA patent/SG10201802390XA/en unknown
- 2013-10-21 WO PCT/SG2013/000453 patent/WO2014062138A1/en active Application Filing
- 2013-10-21 SG SG11201503045YA patent/SG11201503045YA/en unknown
- 2013-10-21 EP EP13848074.4A patent/EP2909312A4/en not_active Withdrawn
- 2013-10-21 CN CN201380066462.7A patent/CN104995294A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20150329821A1 (en) | 2015-11-19 |
WO2014062138A1 (en) | 2014-04-24 |
EP2909312A1 (en) | 2015-08-26 |
CN104995294A (en) | 2015-10-21 |
EP2909312A4 (en) | 2016-06-22 |
JP2015534805A (en) | 2015-12-07 |
SG11201503045YA (en) | 2015-05-28 |
JP6494515B2 (en) | 2019-04-03 |
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