HK1202333A1 - Combination of kinase inhibitors and uses thereof - Google Patents
Combination of kinase inhibitors and uses thereof Download PDFInfo
- Publication number
- HK1202333A1 HK1202333A1 HK15102758.1A HK15102758A HK1202333A1 HK 1202333 A1 HK1202333 A1 HK 1202333A1 HK 15102758 A HK15102758 A HK 15102758A HK 1202333 A1 HK1202333 A1 HK 1202333A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- combination
- kinase inhibitors
- kinase
- rtk
- treating
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558928P | 2011-11-11 | 2011-11-11 | |
| US201161558928P | 2011-11-11 | ||
| PCT/US2012/064719 WO2013071264A1 (en) | 2011-11-11 | 2012-11-12 | Combination of kinase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1202333A1 true HK1202333A1 (en) | 2015-09-25 |
Family
ID=48290670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15102758.1A HK1202333A1 (en) | 2011-11-11 | 2012-11-12 | Combination of kinase inhibitors and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9682141B2 (enExample) |
| EP (1) | EP2776837A4 (enExample) |
| JP (1) | JP6126615B2 (enExample) |
| CN (1) | CN104204804B (enExample) |
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| JP6434416B2 (ja) | 2012-11-08 | 2018-12-05 | ライゼン・ファーマシューティカルズ・エスアー | PDE4阻害剤とPI3δ阻害剤または二重PI3δ−γキナーゼ阻害剤とを含有する薬学的組成物 |
| CN104177346A (zh) * | 2013-05-21 | 2014-12-03 | 苏州科捷生物医药有限公司 | 喹唑啉类化合物及其用途 |
| EP3110801B1 (en) * | 2014-02-27 | 2019-01-30 | Council Of Scientific & Industrial Research | 6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors |
| CN103864800A (zh) * | 2014-04-03 | 2014-06-18 | 定陶县友帮化工有限公司 | 6-氯咪唑并[1,2-b]哒嗪的合成方法 |
| JP6377400B2 (ja) * | 2014-05-08 | 2018-08-22 | 株式会社小糸製作所 | 車両用灯具 |
| TW201613919A (en) | 2014-07-02 | 2016-04-16 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| WO2016176579A1 (en) * | 2015-04-29 | 2016-11-03 | Psivida Us, Inc. | Injectable sustained release intraocular device |
| BR112017023762A2 (pt) * | 2015-05-05 | 2018-07-31 | Psivida Us, Inc. | formulações de depósito injetáveis |
| WO2016210345A1 (en) * | 2015-06-25 | 2016-12-29 | The California Institute For Biomedical Research | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 |
| CN105085503A (zh) * | 2015-09-20 | 2015-11-25 | 徐敬媛 | 一种治疗呼吸道感染的药物组合物 |
| US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
| CN106483293A (zh) * | 2016-10-13 | 2017-03-08 | 广州华弘生物科技有限公司 | He4a 临床免疫检测试剂盒及其制备方法 |
| CN106632351A (zh) * | 2016-11-18 | 2017-05-10 | 山东友帮生化科技有限公司 | 6‑溴咪唑并[1,2‑a]吡嗪‑3‑羧酸乙酯的制法 |
| EP3348144A3 (en) * | 2017-01-17 | 2018-10-03 | OxiScience LLC | Composition for the prevention and elimination of odors |
| US11337965B2 (en) | 2017-08-25 | 2022-05-24 | Memorial Sloan Kettering Cancer Center | Kinase mutation-associated neurodegenerative disorders |
| JP7768505B2 (ja) | 2018-06-01 | 2025-11-12 | コーネル・ユニバーシティー | Pi3kに関連する疾患または障害に対する併用療法 |
| CN112469707B (zh) * | 2018-06-27 | 2024-06-21 | 利伯纳生物科学株式会社 | 脊髓性肌萎缩症的预防剂或治疗剂 |
| EP3867238B1 (en) | 2018-10-17 | 2023-06-07 | Array BioPharma Inc. | Protein tyrosine phosphatase inhibitors |
| EP3883935A4 (en) * | 2018-11-20 | 2022-08-10 | Georgetown University | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE, MYODEGENERATIVE AND LYSOSOMAL STORAGE DISORDERS |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| US20220202792A1 (en) * | 2019-04-26 | 2022-06-30 | University Of Houston System | Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues |
| CN110051859B (zh) * | 2019-06-06 | 2020-06-12 | 鲁南制药集团股份有限公司 | 一种阿昔替尼环糊精包合物 |
| CN111187181B (zh) * | 2019-11-22 | 2023-05-05 | 吉林大学 | 一种2-(4-氨基苯基)-2-甲基丙腈化合物的制备方法 |
| US20240350492A1 (en) | 2020-07-10 | 2024-10-24 | Ting Therapeutics Llc | Methods for the Prevention and Treatment of Hearing Loss |
| US12398156B2 (en) * | 2020-08-21 | 2025-08-26 | 1ST Biotherapeutics, Inc. | Compounds for prevention or treatment of neurodegenerative disorders |
| US20250230138A1 (en) * | 2022-02-08 | 2025-07-17 | Theras, Inc. | Compounds having a t-structure formed by at least four cycles for use in the treatment of cancer and other indications |
| WO2024008799A1 (en) * | 2022-07-06 | 2024-01-11 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of proliferative glomerulonephritis |
| TWI866545B (zh) * | 2022-10-20 | 2024-12-11 | 南韓商東亞St股份有限公司 | 氮雜環丁烷基苯并唑化合物及其等作為mer及axl抑制劑的用途 |
| CN116425743B (zh) * | 2022-12-30 | 2025-06-17 | 贵州医科大学 | 一种作为PI3Kα激酶抑制剂的苯并杂环类化合物及其制备方法与应用 |
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| WO2006110811A1 (en) * | 2005-04-12 | 2006-10-19 | Elan Pharma International Limited | Nanoparticulate quinazoline derivative formulations |
| TW200801012A (en) * | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| RS52939B (sr) * | 2007-04-10 | 2014-02-28 | Exelixis Inc. | Postupci za lečenje kancera upotrebom piridopirimidinonskih inhibitora pi3k alfa |
| EP2205242B1 (en) * | 2007-09-12 | 2015-04-15 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| JP2011525535A (ja) * | 2008-06-24 | 2011-09-22 | 武田薬品工業株式会社 | PI3K/mTOR阻害剤 |
| UA111579C2 (uk) | 2009-08-17 | 2016-05-25 | Інтеллікіне Ллк | ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ |
| EP2475789A4 (en) | 2009-09-09 | 2013-12-18 | Quintiles Transnat Corp | METHODS FOR PREDICTING SENSITIVITY OF DISEASE OR DISORDER TO RECEPTOR TYROSINE KINASE INHIBITOR THROUGH MUTATION ANALYSIS IN PIK3CA GENE |
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- 2012-11-12 EP EP12847622.3A patent/EP2776837A4/en not_active Withdrawn
- 2012-11-12 HK HK15102758.1A patent/HK1202333A1/xx unknown
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- 2012-11-12 CA CA2855666A patent/CA2855666A1/en not_active Abandoned
- 2012-11-12 JP JP2014541388A patent/JP6126615B2/ja active Active
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| US9682141B2 (en) | 2017-06-20 |
| US20150030588A1 (en) | 2015-01-29 |
| JP2014533284A (ja) | 2014-12-11 |
| CN104204804A (zh) | 2014-12-10 |
| WO2013071264A1 (en) | 2013-05-16 |
| EP2776837A1 (en) | 2014-09-17 |
| CN104204804B (zh) | 2016-09-28 |
| JP6126615B2 (ja) | 2017-05-10 |
| EP2776837A4 (en) | 2015-05-20 |
| CA2855666A1 (en) | 2013-05-16 |
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