HK1202289A1 - 用於製備螺旋吲哚酮及其中間產物之化學程序 - Google Patents

用於製備螺旋吲哚酮及其中間產物之化學程序

Info

Publication number
HK1202289A1
HK1202289A1 HK15102724.2A HK15102724A HK1202289A1 HK 1202289 A1 HK1202289 A1 HK 1202289A1 HK 15102724 A HK15102724 A HK 15102724A HK 1202289 A1 HK1202289 A1 HK 1202289A1
Authority
HK
Hong Kong
Prior art keywords
spiroindolones
intermediates
preparing
chemical process
chemical
Prior art date
Application number
HK15102724.2A
Other languages
English (en)
Inventor
Michael Crowe
Michael Foulkes
Giancarlo Francese
Dominique Grimler
Ernst Kuesters
Kurt Laumen
Yunzhong Li
Changxue Lin
Jovana Nazor
Thomas Ruch
Derek Smith
Shiwei Song
Shangjun Teng
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1202289A1 publication Critical patent/HK1202289A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
HK15102724.2A 2012-03-23 2015-03-17 用於製備螺旋吲哚酮及其中間產物之化學程序 HK1202289A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012000359 2012-03-23
PCT/EP2013/056170 WO2013139987A1 (en) 2012-03-23 2013-03-22 Chemical process for preparing spiroindolones and intermediates thereof

Publications (1)

Publication Number Publication Date
HK1202289A1 true HK1202289A1 (zh) 2015-09-25

Family

ID=48048006

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102724.2A HK1202289A1 (zh) 2012-03-23 2015-03-17 用於製備螺旋吲哚酮及其中間產物之化學程序

Country Status (21)

Country Link
US (1) US9598712B2 (zh)
EP (2) EP2828256B1 (zh)
JP (1) JP6117906B2 (zh)
KR (1) KR102057590B1 (zh)
AP (1) AP2014007906A0 (zh)
AU (1) AU2013237330C1 (zh)
BR (1) BR112014022909B1 (zh)
CA (1) CA2866222C (zh)
CY (1) CY1122087T1 (zh)
DK (1) DK2828256T5 (zh)
ES (2) ES2962530T3 (zh)
HK (1) HK1202289A1 (zh)
HR (1) HRP20191632T1 (zh)
HU (1) HUE046421T2 (zh)
LT (1) LT2828256T (zh)
MX (1) MX354023B (zh)
PL (1) PL2828256T3 (zh)
PT (1) PT2828256T (zh)
RU (1) RU2662815C2 (zh)
SI (1) SI2828256T1 (zh)
WO (1) WO2013139987A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53837A (fr) 2014-12-18 2021-11-10 Hoffmann La Roche Tetrahydro-pyrido[3,4-b]indoles modulateurs des récepteurs des oestrogènes et leurs utilisations
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
JP6916969B1 (ja) 2018-06-21 2021-08-11 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ３−（（１Ｒ，３Ｒ）−１−（２，６−ジフルオロ−４−（（１−（３−フルオロプロピル）アゼチジン−３−イル）アミノ）フェニル）−３−メチル−１，３，４，９−テトラヒドロ−２Ｈ−ピリド［３，４−ｂ］インドール−２−イル）−２，２−ジフルオロプロパン−１−オールの固体形態及び置換されたフェニル又はピリジニル部分を含む縮合三環式化合物を調製するための方法とそれらの使用方法
CA3179751A1 (en) * 2020-04-10 2021-10-14 Codexis, Inc. Engineered transaminase polypeptides
US20240026401A1 (en) * 2020-09-28 2024-01-25 Codexis, Inc. Engineered biocatalysts and methods for synthesizing chiral amines

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US2947758A (en) * 1959-04-28 1960-08-02 Searle & Co 3-(omega-hydrazino) alkylindoles
GB974895A (en) * 1961-04-06 1964-11-11 Parke Davis & Co Process for the production of amine compounds
GB974893A (en) * 1961-04-06 1964-11-11 Parke Davis & Co Amine compounds and means of producing the same
US3183170A (en) * 1961-10-03 1965-05-11 Sanraku Ocean Kabushiki Kaisha Method of l-amino acid manufacture
BE795457A (fr) * 1972-02-16 1973-08-16 Clin Midy Amines indoliques, leur preparation et leur application en therapeutiques
US4073795A (en) * 1976-06-22 1978-02-14 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4331818A (en) * 1980-03-19 1982-05-25 The Procter & Gamble Company Chiral phospine ligand
DE3307095A1 (de) * 1983-03-01 1984-09-06 Degussa Ag, 6000 Frankfurt Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung
US4518692A (en) * 1983-09-01 1985-05-21 Genetics Institute, Inc. Production of L-amino acids by transamination
HU193902B (en) * 1983-09-01 1987-12-28 Genetics Inst Process for preparing l-amino acids by means of transamination
US4859591A (en) 1984-07-05 1989-08-22 W. R. Grace & Co.-Conn. Transamination process for producing amino acids
US4826766A (en) 1985-09-23 1989-05-02 Genetics Institute, Inc. Production of amino acids using coupled aminotransferases
CA2533838A1 (en) 2003-08-11 2005-02-24 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
US7541091B2 (en) 2004-05-18 2009-06-02 M & G Usa Corporation Compartmentalized resin pellets for oxygen scavenging
CA2583426A1 (en) * 2004-10-05 2006-04-13 Ajinomoto Co., Inc. Process for producing amino acid derivative from hydroxyimino acid
WO2008050207A1 (en) * 2006-10-25 2008-05-02 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
US7588923B2 (en) 2007-03-02 2009-09-15 Richmond Chemical Corporation Method to increase the yield and improve purification of products from transaminase reactions
JP5438098B2 (ja) * 2008-04-29 2014-03-12 ノバルティス アーゲー 寄生虫性疾患の処置のためのスピロ−インドール誘導体
AT507050B1 (de) * 2008-06-17 2010-06-15 Angewandte Biokatalyse Kompete Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen
EP3354727B1 (en) 2009-01-08 2020-10-07 Codexis, Inc. Transaminase polypeptides
US20140199734A1 (en) 2010-07-14 2014-07-17 Dsm Ip Assets B.V. (r)- selective amination
HUE036985T2 (hu) * 2012-03-23 2018-08-28 Codexis Inc Biokatalizátor és eljárások triptamin és triptamin-analógok származékainak szintetizálására

Also Published As

Publication number Publication date
CY1122087T1 (el) 2020-11-25
JP6117906B2 (ja) 2017-04-19
BR112014022909B1 (pt) 2021-11-03
HRP20191632T1 (hr) 2019-12-13
EP2828256A1 (en) 2015-01-28
AU2013237330B2 (en) 2015-12-03
KR102057590B1 (ko) 2019-12-19
MX2014011489A (es) 2015-05-11
ES2962530T3 (es) 2024-03-19
RU2014142621A (ru) 2016-05-20
PL2828256T3 (pl) 2019-12-31
AU2013237330C1 (en) 2016-08-25
PT2828256T (pt) 2019-10-18
LT2828256T (lt) 2019-09-25
US9598712B2 (en) 2017-03-21
RU2662815C2 (ru) 2018-07-31
WO2013139987A1 (en) 2013-09-26
AP2014007906A0 (en) 2014-08-31
KR20140137374A (ko) 2014-12-02
EP3578557B1 (en) 2023-09-20
US20150045562A1 (en) 2015-02-12
MX354023B (es) 2018-02-08
AU2013237330A1 (en) 2014-09-25
DK2828256T5 (da) 2019-12-09
DK2828256T3 (da) 2019-10-07
ES2748460T3 (es) 2020-03-16
HUE046421T2 (hu) 2020-02-28
EP2828256B1 (en) 2019-07-03
JP2015512381A (ja) 2015-04-27
EP3578557A1 (en) 2019-12-11
SI2828256T1 (sl) 2019-11-29
CA2866222C (en) 2022-01-11
BR112014022909A2 (pt) 2017-07-18
CA2866222A1 (en) 2013-09-26

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