HK1201585A1 - Use of an anti alpha synuclein antibody to diagnose an elevated level of alpha synuclein in the brain - Google Patents

Use of an anti alpha synuclein antibody to diagnose an elevated level of alpha synuclein in the brain

Info

Publication number
HK1201585A1
HK1201585A1 HK15102107.9A HK15102107A HK1201585A1 HK 1201585 A1 HK1201585 A1 HK 1201585A1 HK 15102107 A HK15102107 A HK 15102107A HK 1201585 A1 HK1201585 A1 HK 1201585A1
Authority
HK
Hong Kong
Prior art keywords
alpha synuclein
diagnose
brain
elevated level
antibody
Prior art date
Application number
HK15102107.9A
Other languages
English (en)
Chinese (zh)
Inventor
Andreas Weihofen
Thomas Engber
Jan Grimm
Original Assignee
Biogen Internat Neuroscience Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Internat Neuroscience Gmbh filed Critical Biogen Internat Neuroscience Gmbh
Publication of HK1201585A1 publication Critical patent/HK1201585A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/38Pediatrics
    • G01N2800/385Congenital anomalies
    • G01N2800/387Down syndrome; Trisomy 18; Trisomy 13

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK15102107.9A 2011-11-02 2015-03-02 Use of an anti alpha synuclein antibody to diagnose an elevated level of alpha synuclein in the brain HK1201585A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161554924P 2011-11-02 2011-11-02
PCT/US2012/062430 WO2013066818A1 (en) 2011-11-02 2012-10-29 USE OF AN ANTI-α-SYNUCLEIN ANTIBODY TO DIAGNOSE AN ELEVATED LEVEL OF α-SYNUCLEIN IN THE BRAIN

Publications (1)

Publication Number Publication Date
HK1201585A1 true HK1201585A1 (en) 2015-09-04

Family

ID=48192661

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15102107.9A HK1201585A1 (en) 2011-11-02 2015-03-02 Use of an anti alpha synuclein antibody to diagnose an elevated level of alpha synuclein in the brain

Country Status (14)

Country Link
US (3) US20140295465A1 (ko)
EP (1) EP2773957B1 (ko)
JP (1) JP6263473B2 (ko)
KR (1) KR102036938B1 (ko)
CN (2) CN107091931A (ko)
AU (1) AU2012332814B2 (ko)
BR (1) BR112014010664A2 (ko)
CA (1) CA2854131C (ko)
EA (1) EA034213B1 (ko)
HK (1) HK1201585A1 (ko)
IL (1) IL232373B (ko)
MX (1) MX356797B (ko)
WO (1) WO2013066818A1 (ko)
ZA (1) ZA201403879B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2949666B1 (en) 2008-12-19 2018-12-19 Biogen International Neuroscience GmbH Human anti-alpha-synuclein antibodies
AU2012272790B2 (en) 2011-06-23 2016-10-06 Biogen International Neuroscience Gmbh Anti-alpha synuclein binding molecules
CN107074938A (zh) 2014-10-16 2017-08-18 豪夫迈·罗氏有限公司 抗‑α‑突触核蛋白抗体和使用方法
JP6273338B1 (ja) * 2016-12-05 2018-01-31 磁量生技股▲ふん▼有限公司 パーキンソン病からパーキンソン病認知症を特定する方法
EP3567054A4 (en) * 2017-01-06 2021-03-10 ABL Bio Inc. ANTI-ALPHA SYN ANTIBODIES AND USES THEREOF
CN110494445B (zh) * 2017-01-06 2023-10-20 Abl生物公司 抗α-SYN抗体及其用途
WO2018151821A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
GB201803553D0 (en) 2018-03-06 2018-04-18 Univ Newcastle Detection of pathological protein aggregation
WO2020009482A1 (ko) * 2018-07-03 2020-01-09 에이비엘바이오 주식회사 항 알파-시누클레인 항체 및 그 용도
EP3629021A1 (en) * 2018-09-26 2020-04-01 Euroimmun Medizinische Labordiagnostika AG Diagnosis of a neuroautoimmune disease
KR102252879B1 (ko) * 2019-11-15 2021-05-17 성균관대학교산학협력단 혈장 내 aimp2를 이용한 파킨슨 질환의 진단 방법, 이를 위한 조성물 및 이를 포함하는 키트

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
FR2686087A1 (fr) 1992-01-13 1993-07-16 Inst Nat Sante Rech Med Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications.
WO1999050300A1 (en) * 1998-03-30 1999-10-07 The Trustees Of The University Of Pennsylvania Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders
AU7186501A (en) * 2000-07-07 2002-01-21 Panacea Pharmaceuticals Inc Methods for preventing neural tissue damage and for the treatment of alpha-synuclein diseases
GB0203446D0 (en) * 2002-02-14 2002-04-03 Univ Lancaster Detection and/or monitoring of synuclein-related diseases
CA2657953A1 (en) 2005-07-19 2007-01-25 University Of Rochester Alpha-synuclein antibodies and methods related thereto
EA029481B1 (ru) 2007-01-05 2018-04-30 Юнивэсэти Оф Цюрих Способ получения человеческого рекомбинантного антитела, специфично связывающего вариант эндогенного белка, формирующий аномальные патологические белковые структуры путем агрегации, олигомеризации или образования фибрилл
CN101308144A (zh) * 2007-05-16 2008-11-19 首都医科大学宣武医院 检测受试者体液内疾病相关蛋白聚合能力的方法
WO2009133521A2 (en) 2008-04-29 2009-11-05 Bioartic Neuroscience Ab Antibodies and vaccines for use in therapeutic and diagnostic methods for alpha-synuclein-related disorders
EP2949666B1 (en) * 2008-12-19 2018-12-19 Biogen International Neuroscience GmbH Human anti-alpha-synuclein antibodies
CN101692092B (zh) * 2009-09-24 2013-04-10 首都医科大学宣武医院 定量检测人血清中自体α-突触核蛋白抗体的方法

Also Published As

Publication number Publication date
EA034213B1 (ru) 2020-01-17
MX356797B (es) 2018-06-14
NZ625217A (en) 2016-07-29
JP6263473B2 (ja) 2018-01-31
EP2773957A1 (en) 2014-09-10
EA201490883A1 (ru) 2014-10-30
AU2012332814B2 (en) 2017-12-14
BR112014010664A2 (pt) 2017-04-25
EP2773957B1 (en) 2017-11-29
US20190094245A1 (en) 2019-03-28
EP2773957A4 (en) 2015-06-24
WO2013066818A1 (en) 2013-05-10
IL232373A0 (en) 2014-06-30
US20140295465A1 (en) 2014-10-02
CA2854131A1 (en) 2013-05-10
ZA201403879B (en) 2018-11-28
US20180011112A1 (en) 2018-01-11
AU2012332814A1 (en) 2014-06-12
CN107091931A (zh) 2017-08-25
KR20140095074A (ko) 2014-07-31
IL232373B (en) 2018-08-30
CA2854131C (en) 2020-07-07
CN104040342A (zh) 2014-09-10
MX2014005378A (es) 2015-01-19
KR102036938B1 (ko) 2019-10-25
JP2014533357A (ja) 2014-12-11

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