HK1201260A1 - New indanyloxydihydrobenzofuranylacetic acid derivatives and their use as gpr40 receptor agonists gpr40 - Google Patents
New indanyloxydihydrobenzofuranylacetic acid derivatives and their use as gpr40 receptor agonists gpr40Info
- Publication number
- HK1201260A1 HK1201260A1 HK15101722.6A HK15101722A HK1201260A1 HK 1201260 A1 HK1201260 A1 HK 1201260A1 HK 15101722 A HK15101722 A HK 15101722A HK 1201260 A1 HK1201260 A1 HK 1201260A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- gpr40
- acid derivatives
- receptor agonists
- new
- new indanyloxydihydrobenzofuranylacetic
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/4164—1,3-Diazoles
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
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- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12161240 | 2012-03-26 | ||
PCT/EP2013/056312 WO2013144097A1 (en) | 2012-03-26 | 2013-03-25 | New indanyloxydihydrobenzofuranylacetic acid derivatives and their use as gpr40 receptor agonists |
Publications (1)
Publication Number | Publication Date |
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HK1201260A1 true HK1201260A1 (en) | 2015-08-28 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HK15101722.6A HK1201260A1 (en) | 2012-03-26 | 2015-02-16 | New indanyloxydihydrobenzofuranylacetic acid derivatives and their use as gpr40 receptor agonists gpr40 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8642585B2 (ko) |
EP (2) | EP2831064B1 (ko) |
JP (2) | JP6131492B2 (ko) |
KR (1) | KR20140139088A (ko) |
CN (1) | CN104321319A (ko) |
AP (1) | AP2014007903A0 (ko) |
AR (1) | AR090493A1 (ko) |
AU (1) | AU2013241926A1 (ko) |
CA (1) | CA2868474A1 (ko) |
CL (1) | CL2014002556A1 (ko) |
CO (1) | CO7091175A2 (ko) |
EA (1) | EA201401053A1 (ko) |
EC (1) | ECSP14023238A (ko) |
HK (1) | HK1201260A1 (ko) |
MA (1) | MA20150065A1 (ko) |
MX (1) | MX2014011465A (ko) |
PE (1) | PE20142019A1 (ko) |
PH (1) | PH12014502141A1 (ko) |
SG (1) | SG11201405713UA (ko) |
TN (1) | TN2014000398A1 (ko) |
TW (1) | TW201400466A (ko) |
UY (1) | UY34704A (ko) |
WO (2) | WO2013144097A1 (ko) |
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AR084050A1 (es) * | 2010-12-01 | 2013-04-17 | Boehringer Ingelheim Int | Acidos indaniloxidihidrobenzofuranilaceticos |
US8642585B2 (en) * | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
US20160200734A1 (en) * | 2013-08-23 | 2016-07-14 | Xinshan Kang | Carboxylic acid compounds in treatment of diabetes mellitus |
EA201690888A1 (ru) | 2013-11-14 | 2016-10-31 | Кадила Хелзкэр Лимитед | Новые гетероциклические соединения |
EP3076959B1 (en) | 2013-12-04 | 2018-07-04 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
EP3102198B1 (en) | 2014-02-06 | 2020-08-26 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
WO2016022446A1 (en) * | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [5,6]-fused bicyclic antidiabetic compounds |
US20180354962A1 (en) * | 2015-09-09 | 2018-12-13 | Boehringer Ingelheim International Gmbh | [{[2,3-Dihydro-1H-inden-1-yl]amino}-2H,3H-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof |
CN110312706B (zh) | 2016-11-28 | 2023-08-18 | 勃林格殷格翰国际有限公司 | 茚满基氨基吡啶基环丙烷甲酸、其药物组合物及用途 |
CN110198928B (zh) | 2017-01-26 | 2023-08-29 | 勃林格殷格翰国际有限公司 | 苄氧基吡啶基环丙烷甲酸、其药物组合物和用途 |
CN110177773B (zh) | 2017-01-26 | 2023-08-25 | 勃林格殷格翰国际有限公司 | 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途 |
US10253004B2 (en) | 2017-01-26 | 2019-04-09 | Boehringer Ingelheim International Gmbh | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
JP7050792B2 (ja) | 2017-01-26 | 2022-04-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンジルオキシピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
CN110248929B (zh) | 2017-01-26 | 2023-05-12 | 勃林格殷格翰国际有限公司 | 苄基氨基吡嗪基环丙烷甲酸、其药物组合物和用途 |
US10550127B1 (en) | 2017-02-08 | 2020-02-04 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
US11186565B2 (en) | 2017-03-31 | 2021-11-30 | Takeda Pharmaceutical Company Limited | Aromatic compound |
WO2019110464A1 (en) * | 2017-12-04 | 2019-06-13 | Basf Se | Method for preparing ethers of cycloaliphatic or araliphatic diols |
EP3749304A1 (en) * | 2018-02-05 | 2020-12-16 | GlaxoSmithKline Intellectual Property Development Limited | Ghrelin o-acyltransferase inhibitors |
PE20210640A1 (es) | 2018-02-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
WO2019191624A1 (en) | 2018-03-29 | 2019-10-03 | Arbutus Biopharma, Inc. | Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same |
TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
ES2962674T3 (es) | 2018-07-13 | 2024-03-20 | Gilead Sciences Inc | Inhibidores PD-1/PD-L1 |
JP2021536445A (ja) * | 2018-08-29 | 2021-12-27 | ケモセントリックス,インコーポレイティド | 小型分子pd−l1インヒビターによる癌治療法 |
TW202028183A (zh) * | 2018-10-10 | 2020-08-01 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
CN112955435B (zh) | 2018-10-24 | 2024-09-06 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
AU2020363377A1 (en) | 2019-10-07 | 2022-04-21 | Kallyope, Inc. | GPR119 agonists |
CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
AU2021297323A1 (en) | 2020-06-26 | 2023-02-16 | Kallyope, Inc. | AMPK activators |
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EP1559422B1 (en) | 2002-11-08 | 2014-04-30 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
CN1735408A (zh) * | 2002-11-08 | 2006-02-15 | 武田药品工业株式会社 | 受体机能调节剂 |
JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
US7820837B2 (en) | 2003-05-30 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
CA2647811A1 (en) | 2006-03-30 | 2007-10-11 | Asahi Kasei Pharma Corporation | Substituted bicyclic derivative and use thereof |
UA95296C2 (uk) | 2006-06-27 | 2011-07-25 | Такеда Фармасьютікал Компані Лімітед | Конденсовані циклічні сполуки |
EP2289868B1 (en) | 2008-06-25 | 2014-08-13 | Daiichi Sankyo Company, Limited | Carboxylic acid compound |
US8748462B2 (en) | 2008-10-15 | 2014-06-10 | Amgen Inc. | Spirocyclic GPR40 modulators |
WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
TWI543984B (zh) * | 2010-07-09 | 2016-08-01 | 艾伯維公司 | 作為s1p調節劑的螺-哌啶衍生物 |
AR084050A1 (es) | 2010-12-01 | 2013-04-17 | Boehringer Ingelheim Int | Acidos indaniloxidihidrobenzofuranilaceticos |
US8642585B2 (en) * | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
-
2013
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- 2013-03-25 WO PCT/EP2013/056312 patent/WO2013144097A1/en active Application Filing
- 2013-03-25 AU AU2013241926A patent/AU2013241926A1/en not_active Abandoned
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- 2013-03-25 JP JP2015502285A patent/JP6131492B2/ja active Active
- 2013-03-25 KR KR20147030011A patent/KR20140139088A/ko not_active Application Discontinuation
- 2013-03-25 EP EP13712760.1A patent/EP2831064B1/en active Active
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- 2013-03-25 CA CA2868474A patent/CA2868474A1/en not_active Abandoned
- 2013-03-25 PE PE2014001462A patent/PE20142019A1/es not_active Application Discontinuation
- 2013-03-25 CN CN201380026597.0A patent/CN104321319A/zh active Pending
- 2013-03-25 SG SG11201405713UA patent/SG11201405713UA/en unknown
- 2013-03-25 EP EP13724175.8A patent/EP2831053B1/en active Active
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2014
- 2014-09-22 TN TNP2014000398A patent/TN2014000398A1/fr unknown
- 2014-09-25 CL CL2014002556A patent/CL2014002556A1/es unknown
- 2014-09-25 PH PH12014502141A patent/PH12014502141A1/en unknown
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Also Published As
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TN2014000398A1 (en) | 2015-12-21 |
EP2831064B1 (en) | 2016-02-17 |
US8642585B2 (en) | 2014-02-04 |
KR20140139088A (ko) | 2014-12-04 |
MX2014011465A (es) | 2015-01-12 |
AR090493A1 (es) | 2014-11-19 |
ECSP14023238A (es) | 2015-09-30 |
AP2014007903A0 (en) | 2014-08-31 |
CO7091175A2 (es) | 2014-10-21 |
CN104321319A (zh) | 2015-01-28 |
WO2013144098A1 (en) | 2013-10-03 |
JP2015511613A (ja) | 2015-04-20 |
CL2014002556A1 (es) | 2015-02-13 |
WO2013144097A1 (en) | 2013-10-03 |
JP2015511612A (ja) | 2015-04-20 |
EP2831064A1 (en) | 2015-02-04 |
JP6040486B2 (ja) | 2016-12-07 |
EP2831053B1 (en) | 2016-06-22 |
UY34704A (es) | 2013-09-30 |
PH12014502141A1 (en) | 2014-12-01 |
PE20142019A1 (es) | 2014-12-18 |
JP6131492B2 (ja) | 2017-05-24 |
AU2013241926A1 (en) | 2014-09-18 |
EA201401053A1 (ru) | 2015-04-30 |
TW201400466A (zh) | 2014-01-01 |
EP2831053A1 (en) | 2015-02-04 |
MA20150065A1 (fr) | 2015-02-27 |
CA2868474A1 (en) | 2013-10-03 |
SG11201405713UA (en) | 2014-10-30 |
US20130252937A1 (en) | 2013-09-26 |
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