HK1197069A1 - Methods for the synthesis and purification of deoxycholic acid - Google Patents

Methods for the synthesis and purification of deoxycholic acid

Info

Publication number
HK1197069A1
HK1197069A1 HK14110436A HK14110436A HK1197069A1 HK 1197069 A1 HK1197069 A1 HK 1197069A1 HK 14110436 A HK14110436 A HK 14110436A HK 14110436 A HK14110436 A HK 14110436A HK 1197069 A1 HK1197069 A1 HK 1197069A1
Authority
HK
Hong Kong
Prior art keywords
purification
synthesis
methods
deoxycholic acid
deoxycholic
Prior art date
Application number
HK14110436A
Other languages
English (en)
Chinese (zh)
Inventor
Daniel J Ganley
Jeremy Wilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of HK1197069A1 publication Critical patent/HK1197069A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK14110436A 2011-06-16 2014-10-20 Methods for the synthesis and purification of deoxycholic acid HK1197069A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161497924P 2011-06-16 2011-06-16
PCT/US2012/042440 WO2012174229A2 (en) 2011-06-16 2012-06-14 Methods for the synthesis and purification of deoxycholic acid

Publications (1)

Publication Number Publication Date
HK1197069A1 true HK1197069A1 (en) 2015-01-02

Family

ID=47357730

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14110436A HK1197069A1 (en) 2011-06-16 2014-10-20 Methods for the synthesis and purification of deoxycholic acid

Country Status (6)

Country Link
US (1) US20130085125A1 (xx)
EP (2) EP3138850B8 (xx)
ES (2) ES2615267T3 (xx)
HK (1) HK1197069A1 (xx)
TW (2) TWI572616B (xx)
WO (1) WO2012174229A2 (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
US20130102580A1 (en) * 2011-09-22 2013-04-25 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs
CN106146593B (zh) * 2015-04-14 2021-06-01 南京迈诺威医药科技有限公司 一种制备去氧胆酸的方法
WO2017211820A1 (en) 2016-06-06 2017-12-14 Bionice, S.L.U. Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid
WO2018215908A1 (en) * 2017-05-25 2018-11-29 Glenmark Pharmaceuticals Limited Process for the preparation of deoxycholic acid

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2321598A (en) * 1940-10-07 1943-06-15 George A Breon & Company Inc Preparation of desoxycholic acid
GB695504A (en) * 1950-10-18 1953-08-12 Drug Res Inc Method of isolating and purifying cholic and desoxycholic acids
GB716670A (en) * 1951-06-19 1954-10-13 Armour & Co Improved process for purifying desoxycholic acid from contaminating cholic acid
US2891972A (en) * 1952-08-19 1959-06-23 Drug Res Inc Process of separating desoxycholic acid from mixed crude bile acids or salts thereof
US5085864A (en) * 1989-10-30 1992-02-04 Abbott Laboratories Injectable formulation for lipophilic drugs
IL123998A (en) * 1998-04-08 2004-09-27 Galmed Int Ltd Conjugates of bile salts and pharmaceutical preparations containing them
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US7754230B2 (en) 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
ATE521355T1 (de) 2004-05-19 2011-09-15 Los Angeles Biomed Res Inst Verwendung eines detergens zur nicht- chirurgischen entfernung von fett
CN101148468A (zh) * 2006-09-19 2008-03-26 天津科技大学 以动物胆汁为原料高效提取胆红素和胆汁酸技术
MX360094B (es) * 2007-06-19 2018-10-19 Kythera Biopharmaceuticals Inc Star Composición, método y preparación del ácido biliar sintético.
US20080318870A1 (en) * 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
GB2480632A (en) * 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids

Also Published As

Publication number Publication date
EP3138850A1 (en) 2017-03-08
EP3138850B1 (en) 2019-08-07
US20130085125A1 (en) 2013-04-04
ES2746311T3 (es) 2020-03-05
TW201317258A (zh) 2013-05-01
TWI665211B (zh) 2019-07-11
WO2012174229A2 (en) 2012-12-20
WO2012174229A3 (en) 2013-04-11
TWI572616B (zh) 2017-03-01
EP3138850B8 (en) 2019-09-11
EP2721047A2 (en) 2014-04-23
EP2721047B1 (en) 2016-11-16
TW201716424A (zh) 2017-05-16
EP2721047A4 (en) 2014-10-29
ES2615267T3 (es) 2017-06-06

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220609