HK1187609A1 - Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase inhibitors - Google Patents

Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase inhibitors

Info

Publication number
HK1187609A1
HK1187609A1 HK14100511.4A HK14100511A HK1187609A1 HK 1187609 A1 HK1187609 A1 HK 1187609A1 HK 14100511 A HK14100511 A HK 14100511A HK 1187609 A1 HK1187609 A1 HK 1187609A1
Authority
HK
Hong Kong
Prior art keywords
benzyl
phenyl
optionally substituted
disulfanyl
amino
Prior art date
Application number
HK14100511.4A
Other languages
English (en)
Chinese (zh)
Inventor
貝納德．羅克
馬里-克洛德．富尼耶-扎武斯基
Original Assignee
領先藥物公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 領先藥物公司 filed Critical 領先藥物公司
Publication of HK1187609A1 publication Critical patent/HK1187609A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
HK14100511.4A 2005-10-25 2009-05-19 Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase inhibitors HK1187609A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0510862A FR2892413B1 (fr) 2005-10-25 2005-10-25 Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR0604030A FR2892414B1 (fr) 2005-10-25 2006-05-05 Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique

Publications (1)

Publication Number Publication Date
HK1187609A1 true HK1187609A1 (en) 2014-04-11

Family

ID=36582065

Family Applications (2)

Application Number Title Priority Date Filing Date
HK09104545.3A HK1125648A1 (en) 2005-10-25 2009-05-19 Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase n inhibitors
HK14100511.4A HK1187609A1 (en) 2005-10-25 2009-05-19 Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK09104545.3A HK1125648A1 (en) 2005-10-25 2009-05-19 Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase n inhibitors

Country Status (13)

Country Link
US (1) US8247608B2 (ja)
JP (1) JP5177889B2 (ja)
CN (2) CN103351377B (ja)
AT (1) ATE521601T1 (ja)
BR (1) BRPI0617918B8 (ja)
CA (1) CA2627211C (ja)
DK (1) DK1940818T3 (ja)
ES (2) ES2369256T3 (ja)
FR (2) FR2892413B1 (ja)
HK (2) HK1125648A1 (ja)
IL (1) IL191069A (ja)
NO (1) NO20082329L (ja)
ZA (1) ZA200803643B (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR2934267B1 (fr) 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2946650B1 (fr) 2009-06-16 2011-08-19 Sanofi Aventis Esters derives d'azetidines, leur preparation et leur application en therapeutique.
WO2013026942A1 (en) 2011-08-25 2013-02-28 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Tubulin binding agents
JP2013043885A (ja) * 2011-08-26 2013-03-04 Kansai Bunri Sogo Gakuen デヒドロアミノ酸含有グリセロール誘導体
CN102633748A (zh) * 2012-03-22 2012-08-15 盛世泰科生物医药技术(苏州)有限公司 2-甲酸乙酯-5-溴-1,3,4-噻二唑的合成方法
FR2997081B1 (fr) 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
FR2997080B1 (fr) * 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs de neprilysine
TWI712582B (zh) * 2015-10-14 2020-12-11 法商領先藥物公司 用來製備(5s,10s)-10-苄基-16-甲基-11,14,18-三側氧基-15,17,19-三氧雜-2,7,8-三噻基-12-氮二十一烷基-5-銨基(e)-3-羧基丙烯酸鹽的工業方法
EP3488666B1 (en) 2016-07-22 2022-04-13 Lutron Technology Company LLC Modular lighting panel
CN107778205B (zh) * 2016-08-31 2019-10-18 北京工商大学 一种制备3-甲硫基丙胺的方法
FR3077201B1 (fr) 2018-01-26 2020-01-17 Pharmaleads Derives aminoacides contenant un groupement disulfanyle sous forme d'un inhibiteur de nep et d'apn pour la prevention et le traitement des douleurs relatives au nerf trijumeau
TW202029962A (zh) * 2018-10-26 2020-08-16 法商量子基因科技有限公司 胺肽酶a抑制劑及包含其的醫藥組合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2518088B1 (fr) 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
FR2605004B1 (fr) 1986-09-25 1989-01-13 Centre Nat Rech Scient Nouveaux derives d'amino-acides, leur procede de preparation et composition pharmaceutiques les contenant
FR2651229B1 (fr) * 1989-08-24 1991-12-13 Inst Nat Sante Rech Med Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique.
US20050025791A1 (en) * 2002-06-21 2005-02-03 Julius Remenar Pharmaceutical compositions with improved dissolution
US20030199496A1 (en) * 2002-04-22 2003-10-23 Simon David Lew Pharmaceutical compositions containing alpha3beta4 nicotinic receptor antagonists and methods of their use
RU2348629C2 (ru) * 2003-05-30 2009-03-10 Ф.Хоффманн-Ля Рош Аг Производные бензотиазола и их применение при лечении заболеваний, связанных с аденозиновыми a2a-рецепторами

Also Published As

Publication number Publication date
DK1940818T3 (da) 2011-11-21
JP2009513600A (ja) 2009-04-02
FR2892414A1 (fr) 2007-04-27
CN101316833B (zh) 2013-08-14
NO20082329L (no) 2008-05-22
FR2892413A1 (fr) 2007-04-27
HK1125648A1 (en) 2009-08-14
ATE521601T1 (de) 2011-09-15
US20090131509A1 (en) 2009-05-21
FR2892414B1 (fr) 2010-11-26
IL191069A (en) 2014-05-28
ES2369257T3 (es) 2011-11-28
CA2627211C (fr) 2014-07-29
ZA200803643B (en) 2009-02-25
BRPI0617918B8 (pt) 2021-05-25
CA2627211A1 (fr) 2007-05-03
IL191069A0 (en) 2008-12-29
CN103351377B (zh) 2015-05-13
BRPI0617918A2 (pt) 2011-08-09
BRPI0617918B1 (pt) 2020-09-08
JP5177889B2 (ja) 2013-04-10
CN101316833A (zh) 2008-12-03
CN103351377A (zh) 2013-10-16
US8247608B2 (en) 2012-08-21
ES2369256T3 (es) 2011-11-28
FR2892413B1 (fr) 2008-12-19

Similar Documents

Publication Publication Date Title
HK1125648A1 (en) Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase n inhibitors
CY1117449T1 (el) Φαινυλιουχα ν-ακυλο παραγωγα αμινων και αμινοξεων, μεθοδοι για την παραγωγη αυτων, μια φαρμακευτικη συνθεση και η χρηση αυτων
PL1780197T3 (pl) 5-podstawione-2-fenyloaminobenzamidy jako inhibitory MEK
PA8620301A1 (es) Inhibidores heterociclil amino de 11-beta-hidrosiesteroide deshidrogenasa tipo 1
TW200745097A (en) 4-Phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors
BRPI0415960A (pt) composto ou um sal do mesmo, pró-droga de um composto, agente farmacêutico, inibidor de peptidase, composto ou um sal do mesmo, pró-droga de um composto, agente farmacêutico, inibidor de peptidase, uso de um composto,e, método para produzir um composto
SG159388A1 (en) Antibacterial agents
MXPA05005146A (es) Indolpiridinio sustituido como compuestos antiinfecciosos.
BR112012003592B8 (pt) composição farmacêutica contendo derivado de quinolina
CO5720995A2 (es) Compuesto novedoso
TW200734309A (en) Water-soluble benzoazepine compound and its pharmaceutical composition
MX2009003739A (es) Derivados de hidrobenzamida como inhibidores de hsp90.
PL2262751T3 (pl) Zastosowanie kwasu alkanosulfonowego jako środka oczyszczającego z cementów, zapraw i betonów
PE20080835A1 (es) Derivados novedosos de aminopiridina que tienen accion inhibidora selectiva sobre aurora a
UY31917A (es) Compuestos de pirido-pirimidina inhibidores de mtor, composiciones farmaceuticas que los comprenden, procesos para su preparación y su uso como medicamento.
GEP20115166B (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
TN2009000167A1 (en) Crystalline potassium salt of lipoxin a4 analogs
EA200600878A1 (ru) Производные феноксиуксусных кислот, применимые в качестве двойных агонистов активируемого пероксисомным пролифератором рецептора ( ppar )
CO6220854A2 (es) Nuevo procedimiento para la preparacion de 4,4´-(1-metil-1,2-etandiil)-bis-(2,6-piperazindiona)
EP2417115A4 (en) FATTY ACID AMIDE HYDROLASE INHIBITORS
AR075308A1 (es) Composicion para controlar fitoenfermedades y metodo para controlar fitoenfermedades
MXPA05009688A (es) Derivados de naftiridina como agentes antibacterianos.
DE602006007483D1 (ja)
TW200720262A (en) Novel compounds ii
ATE540026T1 (de) Hydroxyphenylsulfonsäureamide als antiapoptotische bcl-inhibitoren