NO20082329L - Aminosyrederivater inneholdende en disulfanylgruppe i formen av blandede disulfanyl- og aminopeptidase-N-inhibitorer - Google Patents
Aminosyrederivater inneholdende en disulfanylgruppe i formen av blandede disulfanyl- og aminopeptidase-N-inhibitorerInfo
- Publication number
- NO20082329L NO20082329L NO20082329A NO20082329A NO20082329L NO 20082329 L NO20082329 L NO 20082329L NO 20082329 A NO20082329 A NO 20082329A NO 20082329 A NO20082329 A NO 20082329A NO 20082329 L NO20082329 L NO 20082329L
- Authority
- NO
- Norway
- Prior art keywords
- benzyl
- phenyl
- optionally substituted
- disulfanyl
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
43 Oppfinnelsen vedrører nye forbindelser ifølge formel (l): H2N-CH(R1)-CH2-S-S-CH2-CH(R2)-CONH-R5, der R1 er en hydrokarbonkjede, fenyl- eller benzylradikal, metylenradikal substituert med en heterosyklisk ring med 5 eller 6 atomer, R2 er et fenyl- eller benzylradikal, en aromatisk heterosyklisk ring med 5 eller 6 atomer, metylengruppe substituert med en heterosyklisk ring med 5 eller 6 atomer, R5 er et CH(R3)-COOR4-radikal der R3 er hydrogen, en OH- eller OR-gruppe, en mettet hydrokarbongruppe, et fenyl- eller benzylradikal og OR4 er hydrofil ester, eller 5- eller 6-leddet heterosyklisk ring som omfatter flere heteroatomer valgt fra en gruppe som består av nitrogen, svovel og oksygen, med minst to nitrogenatomer, der nevnte heterosykliske ring er mulig å substituere med et alkylC1-C6-radikal, fenylradikal eller benzylradikal. Anvendelsen av de oppfinneriske oppfinnelsene i form av legemidler, et farmasøytisk preparat som omfatter nevnte forbindelser, en farmasøytisk akseptabel eksipiens, anvendelsen i sammenheng med minst én type av cannabinoidderivat for å potensere den smertestillende effekten og den anti-depressive effekten av de nye forbindelsene ifølge formel (I) og/eller morfin eller derivatene derav er også tilkjennegjort.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0510862A FR2892413B1 (fr) | 2005-10-25 | 2005-10-25 | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
| FR0604030A FR2892414B1 (fr) | 2005-10-25 | 2006-05-05 | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
| PCT/EP2006/067711 WO2007048787A1 (fr) | 2005-10-25 | 2006-10-24 | Derives d'amino-acides contenant un groupement disulfanyle comme inhibiteurs mixtes de la neprilysine et de l 'aminopeptidase n |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082329L true NO20082329L (no) | 2008-05-22 |
Family
ID=36582065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082329A NO20082329L (no) | 2005-10-25 | 2008-05-22 | Aminosyrederivater inneholdende en disulfanylgruppe i formen av blandede disulfanyl- og aminopeptidase-N-inhibitorer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8247608B2 (no) |
| JP (1) | JP5177889B2 (no) |
| CN (2) | CN101316833B (no) |
| AT (1) | ATE521601T1 (no) |
| BR (1) | BRPI0617918B8 (no) |
| CA (1) | CA2627211C (no) |
| DK (1) | DK1940818T3 (no) |
| ES (2) | ES2369256T3 (no) |
| FR (2) | FR2892413B1 (no) |
| HK (2) | HK1187609A1 (no) |
| IL (1) | IL191069A (no) |
| NO (1) | NO20082329L (no) |
| ZA (1) | ZA200803643B (no) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2931151A1 (fr) * | 2008-05-13 | 2009-11-20 | Pharmaleads Soc Par Actions Si | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
| FR2934267B1 (fr) | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
| FR2946650B1 (fr) | 2009-06-16 | 2011-08-19 | Sanofi Aventis | Esters derives d'azetidines, leur preparation et leur application en therapeutique. |
| US20150018566A1 (en) | 2011-08-25 | 2015-01-15 | The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy | Tubulin binding agents |
| JP2013043885A (ja) * | 2011-08-26 | 2013-03-04 | Kansai Bunri Sogo Gakuen | デヒドロアミノ酸含有グリセロール誘導体 |
| CN102633748A (zh) * | 2012-03-22 | 2012-08-15 | 盛世泰科生物医药技术(苏州)有限公司 | 2-甲酸乙酯-5-溴-1,3,4-噻二唑的合成方法 |
| FR2997081B1 (fr) | 2012-10-23 | 2015-11-27 | Pharmaleads | Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine |
| FR2997080B1 (fr) * | 2012-10-23 | 2015-11-27 | Pharmaleads | Inhibiteurs de neprilysine |
| TWI712582B (zh) * | 2015-10-14 | 2020-12-11 | 法商領先藥物公司 | 用來製備(5s,10s)-10-苄基-16-甲基-11,14,18-三側氧基-15,17,19-三氧雜-2,7,8-三噻基-12-氮二十一烷基-5-銨基(e)-3-羧基丙烯酸鹽的工業方法 |
| CN109691230B (zh) | 2016-07-22 | 2021-09-03 | 路创技术有限责任公司 | 模块化照明面板 |
| CN107778205B (zh) * | 2016-08-31 | 2019-10-18 | 北京工商大学 | 一种制备3-甲硫基丙胺的方法 |
| FR3077201B1 (fr) | 2018-01-26 | 2020-01-17 | Pharmaleads | Derives aminoacides contenant un groupement disulfanyle sous forme d'un inhibiteur de nep et d'apn pour la prevention et le traitement des douleurs relatives au nerf trijumeau |
| TW202029962A (zh) * | 2018-10-26 | 2020-08-16 | 法商量子基因科技有限公司 | 胺肽酶a抑制劑及包含其的醫藥組合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2518088B1 (fr) | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
| FR2605004B1 (fr) | 1986-09-25 | 1989-01-13 | Centre Nat Rech Scient | Nouveaux derives d'amino-acides, leur procede de preparation et composition pharmaceutiques les contenant |
| FR2651229B1 (fr) * | 1989-08-24 | 1991-12-13 | Inst Nat Sante Rech Med | Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique. |
| US20030199496A1 (en) * | 2002-04-22 | 2003-10-23 | Simon David Lew | Pharmaceutical compositions containing alpha3beta4 nicotinic receptor antagonists and methods of their use |
| EP1515703A1 (en) * | 2002-06-21 | 2005-03-23 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| MXPA05012772A (es) * | 2003-05-30 | 2006-02-13 | Hoffmann La Roche | Derivados de benzotiazol y uso de los mismos en el tratamiento de enfermedades relacionadas con el receptor a2a de adenosina. |
-
2001
- 2001-06-20 ES ES01946659T patent/ES2369256T3/es not_active Expired - Lifetime
-
2005
- 2005-10-25 FR FR0510862A patent/FR2892413B1/fr not_active Expired - Fee Related
-
2006
- 2006-05-05 FR FR0604030A patent/FR2892414B1/fr active Active
- 2006-10-24 CN CN2006800442299A patent/CN101316833B/zh active Active
- 2006-10-24 AT AT06807506T patent/ATE521601T1/de not_active IP Right Cessation
- 2006-10-24 CA CA2627211A patent/CA2627211C/fr active Active
- 2006-10-24 JP JP2008537082A patent/JP5177889B2/ja active Active
- 2006-10-24 ES ES06807506T patent/ES2369257T3/es active Active
- 2006-10-24 US US12/084,091 patent/US8247608B2/en active Active
- 2006-10-24 DK DK06807506.8T patent/DK1940818T3/da active
- 2006-10-24 CN CN201310280813.6A patent/CN103351377B/zh active Active
- 2006-10-24 BR BRPI0617918A patent/BRPI0617918B8/pt active IP Right Grant
-
2008
- 2008-04-24 ZA ZA200803643A patent/ZA200803643B/xx unknown
- 2008-04-27 IL IL191069A patent/IL191069A/en active IP Right Grant
- 2008-05-22 NO NO20082329A patent/NO20082329L/no not_active Application Discontinuation
-
2009
- 2009-05-19 HK HK14100511.4A patent/HK1187609A1/xx unknown
- 2009-05-19 HK HK09104545.3A patent/HK1125648A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103351377A (zh) | 2013-10-16 |
| FR2892413B1 (fr) | 2008-12-19 |
| BRPI0617918B8 (pt) | 2021-05-25 |
| JP2009513600A (ja) | 2009-04-02 |
| HK1187609A1 (en) | 2014-04-11 |
| IL191069A (en) | 2014-05-28 |
| DK1940818T3 (da) | 2011-11-21 |
| ES2369257T3 (es) | 2011-11-28 |
| ZA200803643B (en) | 2009-02-25 |
| CN101316833B (zh) | 2013-08-14 |
| CN101316833A (zh) | 2008-12-03 |
| ATE521601T1 (de) | 2011-09-15 |
| FR2892414B1 (fr) | 2010-11-26 |
| CA2627211A1 (fr) | 2007-05-03 |
| ES2369256T3 (es) | 2011-11-28 |
| BRPI0617918A2 (pt) | 2011-08-09 |
| FR2892413A1 (fr) | 2007-04-27 |
| FR2892414A1 (fr) | 2007-04-27 |
| CA2627211C (fr) | 2014-07-29 |
| BRPI0617918B1 (pt) | 2020-09-08 |
| HK1125648A1 (en) | 2009-08-14 |
| US8247608B2 (en) | 2012-08-21 |
| JP5177889B2 (ja) | 2013-04-10 |
| US20090131509A1 (en) | 2009-05-21 |
| IL191069A0 (en) | 2008-12-29 |
| CN103351377B (zh) | 2015-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |