HK1186484A1 - 同等型富集的抗體製備物及其獲得方法 - Google Patents

同等型富集的抗體製備物及其獲得方法

Info

Publication number
HK1186484A1
HK1186484A1 HK13114018.4A HK13114018A HK1186484A1 HK 1186484 A1 HK1186484 A1 HK 1186484A1 HK 13114018 A HK13114018 A HK 13114018A HK 1186484 A1 HK1186484 A1 HK 1186484A1
Authority
HK
Hong Kong
Prior art keywords
obtaining
antibody preparation
enriched antibody
isoform
isoform enriched
Prior art date
Application number
HK13114018.4A
Other languages
English (en)
Inventor
Roberto Falkenstein
Klaus Schwendner
Bernhard Spensberger
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43799680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1186484(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1186484A1 publication Critical patent/HK1186484A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK13114018.4A 2010-12-21 2013-12-18 同等型富集的抗體製備物及其獲得方法 HK1186484A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10196287 2010-12-21
PCT/EP2011/073245 WO2012084829A1 (en) 2010-12-21 2011-12-19 Isoform enriched antibody preparation and method for obtaining it

Publications (1)

Publication Number Publication Date
HK1186484A1 true HK1186484A1 (zh) 2014-03-14

Family

ID=43799680

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13114018.4A HK1186484A1 (zh) 2010-12-21 2013-12-18 同等型富集的抗體製備物及其獲得方法

Country Status (11)

Country Link
US (2) US20140162317A1 (zh)
EP (1) EP2655412B1 (zh)
JP (1) JP5838221B2 (zh)
KR (1) KR101574864B1 (zh)
CN (1) CN103380144B (zh)
BR (1) BR112013012422A2 (zh)
CA (1) CA2820095C (zh)
HK (1) HK1186484A1 (zh)
MX (1) MX357821B (zh)
RU (1) RU2586515C2 (zh)
WO (1) WO2012084829A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ575328A (en) 2006-09-13 2012-06-29 Abbott Lab Cell culture improvements
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
AU2009307737B2 (en) 2008-10-20 2015-07-23 Abbvie Inc. Viral inactivation during purification of antibodies
JP5808249B2 (ja) 2008-10-20 2015-11-10 アッヴィ・インコーポレイテッド プロテインａアフィニティークロマトグラフィーを用いる抗体の単離および精製
EP2920586A4 (en) * 2012-11-15 2017-01-04 F. Hoffmann-La Roche SA IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY
WO2015064971A1 (ko) * 2013-10-30 2015-05-07 (주)셀트리온 양이온 교환 크로마토그래피를 이용한 항체의 아형 분리 방법
WO2015083853A1 (ko) * 2013-12-05 2015-06-11 한화케미칼 주식회사 이성질 항체의 함량 조절을 통한 항체 제조 방법
JP2021006540A (ja) * 2014-09-10 2021-01-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ガラクトース操作型免疫グロブリン１抗体
CA3010612A1 (en) * 2016-01-08 2017-07-13 Oncobiologics, Inc. Methods for separating isoforms of monoclonal antibodies
KR102140693B1 (ko) * 2017-04-14 2020-08-05 에이치케이이노엔 주식회사 양이온 교환 크로마토그래피를 이용한 유사항체 정제 방법

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
CA2103059C (en) 1991-06-14 2005-03-22 Paul J. Carter Method for making humanized antibodies
WO1993021319A1 (en) 1992-04-08 1993-10-28 Cetus Oncology Corporation HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
CA2120745A1 (en) 1992-06-30 1994-01-06 Philip G. Kasprzyk A combination of anti-erbb-2 monoclonal antibodies and method of using
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
JPH11510170A (ja) 1995-07-27 1999-09-07 ジェネンテック インコーポレーテッド タンパク質の処方
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
AU760048B2 (en) 1998-05-06 2003-05-08 Genentech Inc. Protein purification by ion exchange chromatography
CN100340575C (zh) 1999-06-25 2007-10-03 杰南技术公司 人源化抗ErbB2抗体及其在制备药物中的应用
WO2003066662A2 (en) 2002-02-05 2003-08-14 Genentech, Inc. Protein purification
EP3388452A3 (en) * 2002-09-11 2019-02-20 Genentech, Inc. Protein purification
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
WO2004076485A1 (en) * 2003-02-28 2004-09-10 Lonza Biologics Plc. Antibody purification by protein a and ion exchange chromatography
CA2583578C (en) * 2004-10-21 2014-04-01 Ge Healthcare Bio-Sciences Ab Chromatography ligand
CA2604877A1 (en) * 2005-04-11 2006-10-19 J.P. Sercel Associates Inc. Protein purification
TWI391399B (zh) * 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
KR20140071452A (ko) * 2006-04-05 2014-06-11 애브비 바이오테크놀로지 리미티드 항체 정제
WO2008025748A1 (en) * 2006-08-28 2008-03-06 Ares Trading S.A. Process for the purification of fc-containing proteins
AU2008206923A1 (en) * 2007-01-17 2008-07-24 Merck Serono S.A. Process for the purification of Fc-containing proteins
DK2215117T4 (en) * 2007-10-30 2018-04-09 Genentech Inc ANTISTO PURIFICATION BY CATION CHANGE CHROMATOGRAPHY
AU2009256308A1 (en) 2008-06-03 2009-12-10 Patrys Limited Process for purification of antibodies
SG178078A1 (en) * 2009-07-24 2012-03-29 Hoffmann La Roche Optimizing the production of antibodies

Also Published As

Publication number Publication date
RU2013132405A (ru) 2015-01-27
RU2586515C2 (ru) 2016-06-10
CA2820095A1 (en) 2012-06-28
KR101574864B1 (ko) 2015-12-11
EP2655412B1 (en) 2018-01-17
CN103380144B (zh) 2016-03-02
MX357821B (es) 2018-07-25
KR20130114209A (ko) 2013-10-16
US10087237B2 (en) 2018-10-02
US20140162317A1 (en) 2014-06-12
WO2012084829A1 (en) 2012-06-28
US20170066814A1 (en) 2017-03-09
CN103380144A (zh) 2013-10-30
BR112013012422A2 (pt) 2016-08-30
EP2655412A1 (en) 2013-10-30
JP2014500289A (ja) 2014-01-09
CA2820095C (en) 2019-02-26
JP5838221B2 (ja) 2016-01-06
MX2013007095A (es) 2013-07-29

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