HK1184363A1 - Novel auristatin derivatives and use thereof auristatin - Google Patents

Novel auristatin derivatives and use thereof auristatin

Info

Publication number
HK1184363A1
HK1184363A1 HK13111032.2A HK13111032A HK1184363A1 HK 1184363 A1 HK1184363 A1 HK 1184363A1 HK 13111032 A HK13111032 A HK 13111032A HK 1184363 A1 HK1184363 A1 HK 1184363A1
Authority
HK
Hong Kong
Prior art keywords
auristatin
novel
derivatives
auristatin derivatives
novel auristatin
Prior art date
Application number
HK13111032.2A
Other languages
English (en)
Chinese (zh)
Inventor
漢斯-格奧爾格．萊爾赫
貝婭特麗克絲．斯戴爾特-路德維格
斯文．戈爾菲耶爾
約阿希姆．舒馬赫
厄休拉．克倫茨
Original Assignee
西雅圖遺傳學公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 西雅圖遺傳學公司 filed Critical 西雅圖遺傳學公司
Publication of HK1184363A1 publication Critical patent/HK1184363A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HK13111032.2A 2010-06-10 2013-09-27 Novel auristatin derivatives and use thereof auristatin HK1184363A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10165550 2010-06-10
EP11158464 2011-03-16
PCT/EP2011/059300 WO2011154359A1 (de) 2010-06-10 2011-06-06 Neue auristatin-derivate und ihre verwendung

Publications (1)

Publication Number Publication Date
HK1184363A1 true HK1184363A1 (en) 2014-01-24

Family

ID=44275637

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13111032.2A HK1184363A1 (en) 2010-06-10 2013-09-27 Novel auristatin derivatives and use thereof auristatin

Country Status (8)

Country Link
US (1) US8722629B2 (ja)
EP (1) EP2579887B1 (ja)
JP (1) JP5791707B2 (ja)
CN (1) CN103200950B (ja)
CA (1) CA2801971C (ja)
ES (1) ES2528956T3 (ja)
HK (1) HK1184363A1 (ja)
WO (1) WO2011154359A1 (ja)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
JP5933562B2 (ja) 2010-09-29 2016-06-15 シアトル ジェネティックス， インコーポレイテッド Ｎ−カルボキシアルキル−アウリスタチンおよびその使用
US9029406B2 (en) 2011-03-16 2015-05-12 Seattle Genetics, Inc N-carboxyalkylauristatins and use thereof
CN103826661B (zh) * 2011-04-21 2019-03-05 西雅图基因公司 新的结合剂-药物缀合物(adc)及其用途
SG11201401452PA (en) 2011-11-17 2014-06-27 Pfizer Cytotoxic peptides and antibody drug conjugates thereof
EP2790731A2 (de) * 2011-12-14 2014-10-22 Seattle Genetics, Inc. Fgfr-binder-wirkstoff konjugate und ihre verwendung
US10226535B2 (en) 2012-12-10 2019-03-12 Mersana Therapeutics, Inc. Auristatin compounds and conjugates thereof
CN105358174B (zh) 2013-03-15 2019-03-15 酵活有限公司 具细胞毒性和抗有丝分裂的化合物以及其使用方法
FR3005051A1 (fr) * 2013-04-25 2014-10-31 Pf Medicament Derives de la dolastatine 10 et d'auristatines
US10675355B2 (en) 2013-12-27 2020-06-09 Var2 Pharmaceuticals Aps VAR2CSA-drug conjugates
AU2014373574B2 (en) 2013-12-27 2020-07-16 Zymeworks Bc Inc. Sulfonamide-containing linkage systems for drug conjugates
WO2015162291A1 (en) 2014-04-25 2015-10-29 Pierre Fabre Medicament Igf-1r antibody-drug-conjugate and its use for the treatment of cancer
RU2685259C2 (ru) 2014-04-25 2019-04-17 Пьер Фабр Медикамент Конъюгат антитела и лекарственного средства и его применение для лечения рака
KR102494557B1 (ko) 2014-09-17 2023-02-02 자임워크스 비씨 인코포레이티드 세포독성 및 항유사분열성 화합물, 그리고 이를 이용하는 방법
CN106279352B (zh) 2015-05-29 2020-05-22 上海新理念生物医药科技有限公司 海兔毒素10的衍生物及其应用
WO2017161206A1 (en) 2016-03-16 2017-09-21 Halozyme, Inc. Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
US10517958B2 (en) 2016-10-04 2019-12-31 Zymeworks Inc. Compositions and methods for the treatment of platinum-drug resistant cancer
CN108690119B (zh) * 2018-06-04 2022-04-19 莎穆(上海)生物科技有限公司 一种伊文思蓝修饰的多肽类前药及其制备和应用
JP2024518709A (ja) 2021-04-10 2024-05-02 プロファウンドバイオ ユーエス カンパニー Ｆｏｌｒ１結合剤、そのコンジュゲートおよびこれを使用する方法
AU2022262644A1 (en) 2021-04-23 2023-11-09 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
KR20240051956A (ko) 2021-09-03 2024-04-22 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US6620911B1 (en) * 1998-01-09 2003-09-16 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Anti-cryptococcal peptides
JP2002544242A (ja) 1999-05-14 2002-12-24 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 酵素活性化抗腫瘍プロドラッグ化合物
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6737409B2 (en) 2001-07-19 2004-05-18 Hoffmann-La Roche Inc. Dolastatin 10 derivatives
WO2003026577A2 (en) 2001-09-24 2003-04-03 Seattle Genetics, Inc. P-amidobenzylethers in drug delivery agents
IL161268A0 (en) * 2001-11-07 2004-09-27 Agensys Inc Nucleic acid and corresponding protein entitled 161p2f10b and pharmaceutical and diagnostic compositions containing the same
EP1545613B9 (en) 2002-07-31 2012-01-25 Seattle Genetics, Inc. Auristatin conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
SG195524A1 (en) 2003-11-06 2013-12-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
JP2008519863A (ja) 2004-11-12 2008-06-12 シアトル ジェネティクス インコーポレイティッド Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
WO2007008603A1 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US8871720B2 (en) 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
PL2502938T3 (pl) 2006-10-27 2015-07-31 Genentech Inc Przeciwciała i immunokoniugaty oraz ich zastosowanie
NO2842575T3 (ja) 2008-03-18 2018-02-24
CN103826661B (zh) * 2011-04-21 2019-03-05 西雅图基因公司 新的结合剂-药物缀合物(adc)及其用途

Also Published As

Publication number Publication date
JP5791707B2 (ja) 2015-10-07
ES2528956T3 (es) 2015-02-13
JP2013533228A (ja) 2013-08-22
US8722629B2 (en) 2014-05-13
CA2801971C (en) 2018-07-24
EP2579887A1 (de) 2013-04-17
CN103200950A (zh) 2013-07-10
CN103200950B (zh) 2016-03-16
WO2011154359A1 (de) 2011-12-15
EP2579887B1 (de) 2014-11-12
US20130157960A1 (en) 2013-06-20
CA2801971A1 (en) 2011-12-15

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