HK1184133A1 - -炔-維生素 衍生物 - Google Patents

-炔-維生素 衍生物

Info

Publication number
HK1184133A1
HK1184133A1 HK13111437.3A HK13111437A HK1184133A1 HK 1184133 A1 HK1184133 A1 HK 1184133A1 HK 13111437 A HK13111437 A HK 13111437A HK 1184133 A1 HK1184133 A1 HK 1184133A1
Authority
HK
Hong Kong
Prior art keywords
yne
vitamin
derivative
Prior art date
Application number
HK13111437.3A
Other languages
English (en)
Inventor
斋藤博
小宫山真人
落合銳士
高木健郎
千田貴之
藤田真理子
今泉启郎
金子俊幸
Original Assignee
帝人制藥株式會社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 帝人制藥株式會社 filed Critical 帝人制藥株式會社
Publication of HK1184133A1 publication Critical patent/HK1184133A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK13111437.3A 2010-10-25 2013-10-10 -炔-維生素 衍生物 HK1184133A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010238524 2010-10-25
PCT/JP2011/074414 WO2012057068A1 (ja) 2010-10-25 2011-10-24 ２３－イン－ビタミンｄ３誘導体

Publications (1)

Publication Number Publication Date
HK1184133A1 true HK1184133A1 (zh) 2014-01-17

Family

ID=45993776

Family Applications (2)

Application Number Title Priority Date Filing Date
HK13111437.3A HK1184133A1 (zh) 2010-10-25 2013-10-10 -炔-維生素 衍生物
HK15112013.1A HK1211281A1 (zh) 2010-10-25 2015-12-07 -炔-維生素 衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15112013.1A HK1211281A1 (zh) 2010-10-25 2015-12-07 -炔-維生素 衍生物

Country Status (21)

Country Link
US (2) US9006220B2 (zh)
EP (1) EP2634171B8 (zh)
JP (1) JP5738307B2 (zh)
KR (1) KR101853518B1 (zh)
CN (2) CN103180293B (zh)
AR (1) AR083541A1 (zh)
AU (1) AU2011321624B2 (zh)
BR (1) BR112013009647A2 (zh)
CA (1) CA2815501C (zh)
DK (1) DK2634171T3 (zh)
ES (1) ES2541719T3 (zh)
HK (2) HK1184133A1 (zh)
HU (1) HUE025554T2 (zh)
IL (1) IL225630A0 (zh)
MX (1) MX347126B (zh)
PL (1) PL2634171T3 (zh)
PT (1) PT2634171E (zh)
RU (1) RU2558362C2 (zh)
SG (1) SG189427A1 (zh)
TW (1) TWI503120B (zh)
WO (1) WO2012057068A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201406380A (zh) * 2012-04-24 2014-02-16 Teijin Pharma Ltd 次發性副甲狀腺機能亢進症治療劑
JP2020143008A (ja) * 2019-03-05 2020-09-10 達也 楠堂 新規褐色脂肪細胞分化誘導剤
CN114681467B (zh) * 2022-03-30 2024-03-12 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物在制备抗肿瘤药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
GB9611603D0 (en) 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
TW473469B (en) 1997-06-25 2002-01-21 Teijin Ltd Vitamin D3-derivatives and agents for treating inflammatory respiratory diseases prepared from the same
US6359152B2 (en) * 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US5939406A (en) * 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US6538145B2 (en) * 1998-02-24 2003-03-25 Chugai Seiyaku Kabushiki Kaisha 24-hydroxy vitamin D derivatives
EP1061070B1 (en) * 1998-02-24 2008-07-16 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of ED-71
EP1070704A4 (en) * 1998-04-10 2001-11-07 Chugai Pharmaceutical Co Ltd VITAMIN D DERIVATIVES SUBSTITUTED IN THE 2 BETA POSITION
WO2001062723A1 (fr) 2000-02-28 2001-08-30 Chugai Seiyaku Kabushiki Kaisha DERIVES DE VITAMINE D COMPORTANT DES SUBSTITUANTS EN POSITION 2$g(a)
AU2005289664A1 (en) * 2004-09-24 2006-04-06 Bioxell S.P.A. 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof
JP2009013154A (ja) * 2006-09-29 2009-01-22 Teijin Pharma Ltd ２−置換−１４−エピ−プレビタミンｄ３誘導体

Also Published As

Publication number Publication date
MX347126B (es) 2017-04-17
IL225630A0 (en) 2013-06-27
TW201223531A (en) 2012-06-16
AR083541A1 (es) 2013-03-06
AU2011321624A1 (en) 2013-05-09
HUE025554T2 (en) 2016-02-29
SG189427A1 (en) 2013-05-31
US20150148552A1 (en) 2015-05-28
PL2634171T3 (pl) 2015-12-31
RU2558362C2 (ru) 2015-08-10
MX2013004389A (es) 2013-05-22
JPWO2012057068A1 (ja) 2014-05-12
CA2815501A1 (en) 2012-05-03
DK2634171T3 (en) 2015-07-13
AU2011321624B2 (en) 2015-03-26
EP2634171A1 (en) 2013-09-04
BR112013009647A2 (pt) 2016-07-12
CN104829510B (zh) 2016-05-04
HK1211281A1 (zh) 2016-05-20
EP2634171B1 (en) 2015-07-01
WO2012057068A1 (ja) 2012-05-03
RU2013124033A (ru) 2014-12-10
KR20140001874A (ko) 2014-01-07
US9006220B2 (en) 2015-04-14
KR101853518B1 (ko) 2018-04-30
CN104829510A (zh) 2015-08-12
EP2634171B8 (en) 2016-01-13
JP5738307B2 (ja) 2015-06-24
US20130210781A1 (en) 2013-08-15
CA2815501C (en) 2018-10-16
US9079843B2 (en) 2015-07-14
EP2634171A4 (en) 2013-11-13
ES2541719T3 (es) 2015-07-24
AU2011321624A8 (en) 2013-09-12
CN103180293A (zh) 2013-06-26
CN103180293B (zh) 2015-06-17
PT2634171E (pt) 2015-09-16
TWI503120B (zh) 2015-10-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191019