HK1181316A1 - 結合劑及其使用方法 - Google Patents

結合劑及其使用方法

Info

Publication number
HK1181316A1
HK1181316A1 HK13108710.7A HK13108710A HK1181316A1 HK 1181316 A1 HK1181316 A1 HK 1181316A1 HK 13108710 A HK13108710 A HK 13108710A HK 1181316 A1 HK1181316 A1 HK 1181316A1
Authority
HK
Hong Kong
Prior art keywords
notch1
methods
binding agents
notch1 binding
agents
Prior art date
Application number
HK13108710.7A
Other languages
English (en)
Inventor
愛德華．特恩．圖恩．范德霍斯特
Original Assignee
昂考梅德藥品有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 昂考梅德藥品有限公司 filed Critical 昂考梅德藥品有限公司
Publication of HK1181316A1 publication Critical patent/HK1181316A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK13108710.7A 2010-01-13 2013-07-25 結合劑及其使用方法 HK1181316A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29476210P 2010-01-13 2010-01-13
US41065110P 2010-11-05 2010-11-05
PCT/US2011/021135 WO2011088215A2 (en) 2010-01-13 2011-01-13 Notch1 binding agents and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1181316A1 true HK1181316A1 (zh) 2013-11-08

Family

ID=44304970

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13108710.7A HK1181316A1 (zh) 2010-01-13 2013-07-25 結合劑及其使用方法

Country Status (8)

Country Link
US (1) US8834875B2 (zh)
EP (1) EP2523682B1 (zh)
CN (1) CN102958534B (zh)
AU (1) AU2011205316B2 (zh)
ES (1) ES2561102T3 (zh)
HK (1) HK1181316A1 (zh)
MX (1) MX2012008085A (zh)
WO (1) WO2011088215A2 (zh)

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JP2009539403A (ja) 2006-06-13 2009-11-19 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌を診断および処置するための組成物および方法
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SG192467A1 (en) 2008-07-08 2013-08-30 Oncomed Pharm Inc Notch1 receptor binding agents and methods of use thereof
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
WO2010146550A1 (en) 2009-06-18 2010-12-23 Pfizer Inc. Anti notch-1 antibodies
BR112013015122A2 (pt) 2010-12-15 2017-05-30 Wyeth Llc anticorpos anti-notch1
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
US9352039B2 (en) 2012-02-09 2016-05-31 The Regents Of The University Of Michigan Method of reducing the number of EMT and MET type breast cancer stem cells
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WO2014172653A2 (en) * 2013-04-19 2014-10-23 Aveo Pharmaceuticals, Inc. Anti-notch1 antibodies
CN103820498B (zh) * 2014-01-29 2016-08-17 中国人民解放军第四军医大学 一种基于Notch信号胞内域NICD1构建的慢病毒表达载体及其应用
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EP3212233B1 (en) * 2014-10-31 2020-06-24 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
CN106591229A (zh) * 2017-01-20 2017-04-26 南京千年健干细胞基因工程有限公司 miR‑34a及靶基因NOTCH1在制备基于间充质干细胞的胶质瘤靶向载体中的应用
WO2019099852A1 (en) * 2017-11-17 2019-05-23 University Of Massachusetts Humanized 2c7 monoclonal antibody directed against a neisseria gonorrhoeae lipooligosaccharide (los) epitope, for human use
EP3877399A4 (en) * 2018-11-06 2022-10-19 Alsatech, Inc. CELL-BASED GENE THERAPY FOR NEURODEGENERATIVE DISEASES

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Also Published As

Publication number Publication date
CN102958534B (zh) 2014-11-05
WO2011088215A2 (en) 2011-07-21
EP2523682B1 (en) 2015-12-16
ES2561102T3 (es) 2016-02-24
AU2011205316A1 (en) 2012-08-02
US8834875B2 (en) 2014-09-16
US20120213786A1 (en) 2012-08-23
WO2011088215A3 (en) 2011-09-29
EP2523682A2 (en) 2012-11-21
AU2011205316B2 (en) 2015-05-28
CN102958534A (zh) 2013-03-06
MX2012008085A (es) 2012-09-12
EP2523682A4 (en) 2013-05-29

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