HK1179946A1 - 作為 配體的三環吲哚衍生物 - Google Patents

作為 配體的三環吲哚衍生物

Info

Publication number
HK1179946A1
HK1179946A1 HK13107025.9A HK13107025A HK1179946A1 HK 1179946 A1 HK1179946 A1 HK 1179946A1 HK 13107025 A HK13107025 A HK 13107025A HK 1179946 A1 HK1179946 A1 HK 1179946A1
Authority
HK
Hong Kong
Prior art keywords
pbr
ligands
indole derivatives
tricyclic indole
tricyclic
Prior art date
Application number
HK13107025.9A
Other languages
English (en)
Inventor
Radha Achanath
Srinath Balaji
Steven Michael Fairway
Dimitrios Mantzilas
Umamaheshwar Mokkapati
Dennis Oshea
Joanna Marie Passmore
Bo Shan
William John Trigg
Harry John Wadsworth
Mohamed Afsal Mohammed Kadavilpparampu
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2010/053998 external-priority patent/WO2010109007A2/en
Priority claimed from GBGB1015203.1A external-priority patent/GB201015203D0/en
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of HK1179946A1 publication Critical patent/HK1179946A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nuclear Medicine (AREA)
HK13107025.9A 2010-03-26 2013-06-14 作為 配體的三環吲哚衍生物 HK1179946A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/EP2010/053998 WO2010109007A2 (en) 2009-03-27 2010-03-26 Indole derivatives
IN1824DE2010 2010-08-02
US12/880,218 US8501153B2 (en) 2009-03-27 2010-09-13 Active enantiomer
GBGB1015203.1A GB201015203D0 (en) 2010-03-26 2010-09-13 Active enantiomer
PCT/EP2011/054744 WO2011117421A1 (en) 2010-03-26 2011-03-28 Tricyclic indole derivatives as pbr ligands

Publications (1)

Publication Number Publication Date
HK1179946A1 true HK1179946A1 (zh) 2013-10-11

Family

ID=44259848

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13107025.9A HK1179946A1 (zh) 2010-03-26 2013-06-14 作為 配體的三環吲哚衍生物

Country Status (16)

Country Link
EP (1) EP2552891B1 (zh)
JP (1) JP5830519B2 (zh)
KR (1) KR101886879B1 (zh)
CN (1) CN102834379B (zh)
AU (1) AU2011231508B2 (zh)
BR (1) BR112012021579A2 (zh)
CA (1) CA2792394C (zh)
ES (1) ES2688574T3 (zh)
HK (1) HK1179946A1 (zh)
IL (1) IL221510A (zh)
MX (1) MX2012010954A (zh)
NZ (1) NZ602025A (zh)
RU (1) RU2551423C2 (zh)
SG (1) SG183837A1 (zh)
WO (1) WO2011117421A1 (zh)
ZA (1) ZA201208067B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201016038D0 (en) * 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
CN104837489A (zh) 2012-11-30 2015-08-12 通用电气健康护理有限公司 三环吲哚衍生物的结晶方法
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
GB201316764D0 (en) * 2013-09-20 2013-11-06 Ge Healthcare Ltd Novel compounds
KR102458116B1 (ko) 2014-12-04 2022-10-24 지이 헬쓰케어 리미티드 방사성 약제로부터의 아세트알데히드의 제거 방법
CN106748802B (zh) * 2016-12-26 2018-11-13 南京理工大学 一种制备含氟仲胺的方法
CN114085221B (zh) * 2021-11-29 2022-12-09 暨南大学 含氮杂环化合物、标记的含氮杂环化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2599740B1 (fr) * 1986-06-05 1988-08-12 Rhone Poulenc Sante Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
EP1423366A1 (en) 2001-08-09 2004-06-02 Eli Lilly And Company Cyclopenta b ! indole derivatives as spla2 inhibitors
GB0523506D0 (en) * 2005-11-18 2005-12-28 Hammersmith Imanet Ltd Novel in vivo imaging compounds
EP2752415B8 (en) * 2006-08-24 2017-11-15 Australian Nuclear Science & Technology Organisation Fluorinated ligands for targeting peripheral benzodiazepine receptors
GB0905328D0 (en) * 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives

Also Published As

Publication number Publication date
JP5830519B2 (ja) 2015-12-09
ZA201208067B (en) 2014-03-26
AU2011231508A1 (en) 2012-10-04
CA2792394A1 (en) 2011-09-29
KR101886879B1 (ko) 2018-08-08
MX2012010954A (es) 2012-11-23
EP2552891A1 (en) 2013-02-06
WO2011117421A1 (en) 2011-09-29
EP2552891B1 (en) 2018-08-08
AU2011231508B2 (en) 2014-07-31
JP2013523621A (ja) 2013-06-17
IL221510A0 (en) 2012-12-02
SG183837A1 (en) 2012-10-30
CN102834379A (zh) 2012-12-19
ES2688574T3 (es) 2018-11-05
KR20130018711A (ko) 2013-02-25
CA2792394C (en) 2018-04-24
RU2551423C2 (ru) 2015-05-27
RU2012141697A (ru) 2014-05-10
IL221510A (en) 2016-02-29
CN102834379B (zh) 2014-12-24
NZ602025A (en) 2014-08-29
BR112012021579A2 (pt) 2019-09-24

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