HK1171225A1 - 乙炔基衍生物 - Google Patents

乙炔基衍生物

Info

Publication number
HK1171225A1
HK1171225A1 HK12112004.5A HK12112004A HK1171225A1 HK 1171225 A1 HK1171225 A1 HK 1171225A1 HK 12112004 A HK12112004 A HK 12112004A HK 1171225 A1 HK1171225 A1 HK 1171225A1
Authority
HK
Hong Kong
Prior art keywords
ethynyl derivatives
ethynyl
derivatives
Prior art date
Application number
HK12112004.5A
Other languages
English (en)
Inventor
盧克．格林
沃爾夫岡．古帕
喬治．耶施克
西內塞．若利多
洛塔爾．林德曼
海因茨．施塔德勒
埃里克．維埃拉
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43446449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1171225(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1171225A1 publication Critical patent/HK1171225A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK12112004.5A 2009-12-17 2012-11-23 乙炔基衍生物 HK1171225A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09179719 2009-12-17
PCT/EP2010/069593 WO2011073172A1 (en) 2009-12-17 2010-12-14 Ethynyl derivatives

Publications (1)

Publication Number Publication Date
HK1171225A1 true HK1171225A1 (zh) 2013-03-22

Family

ID=43446449

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12112004.5A HK1171225A1 (zh) 2009-12-17 2012-11-23 乙炔基衍生物

Country Status (27)

Country Link
US (2) US8586581B2 (zh)
EP (1) EP2513102B1 (zh)
JP (1) JP5763094B2 (zh)
KR (1) KR101407856B1 (zh)
CN (1) CN102686589B (zh)
AR (1) AR079467A1 (zh)
AU (1) AU2010332987B2 (zh)
BR (1) BR112012014770A2 (zh)
CA (1) CA2780155A1 (zh)
CL (1) CL2012001596A1 (zh)
CO (1) CO6531478A2 (zh)
CR (1) CR20120269A (zh)
EC (1) ECSP12011977A (zh)
ES (1) ES2551582T3 (zh)
HK (1) HK1171225A1 (zh)
IL (1) IL219371A (zh)
MA (1) MA33802B1 (zh)
MX (1) MX2012006789A (zh)
MY (1) MY162998A (zh)
NZ (1) NZ599553A (zh)
PE (1) PE20121443A1 (zh)
RU (1) RU2553461C2 (zh)
SG (1) SG181779A1 (zh)
TW (1) TWI448465B (zh)
UA (1) UA107002C2 (zh)
WO (1) WO2011073172A1 (zh)
ZA (1) ZA201204429B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103980129B (zh) * 2010-11-05 2016-08-31 日本欧爱特农业科技株式会社 乙炔基苯脒化合物或其盐、其制备方法和用于农业和园艺的杀菌剂
DK2702051T3 (en) 2011-04-26 2015-03-16 Hoffmann La Roche Ethynyl derivatives AS POSITIVE allosteric modulators mGluR5
US20130123254A1 (en) 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
PL2900659T3 (pl) * 2012-09-27 2017-02-28 F.Hoffmann-La Roche Ag Pochodne aryloetynylowe
AU2013331782B2 (en) * 2012-10-18 2017-03-09 F. Hoffmann-La Roche Ag Ethynyl derivatives as modulators of mGluR5 receptor activity
BR112015009649A2 (pt) * 2012-11-07 2017-07-04 Hoffmann La Roche composto de triazolo
CR20170536A (es) 2015-06-03 2018-02-01 Hoffmann La Roche Derivados de etinilo
MA42442B1 (fr) 2015-07-15 2019-07-31 Hoffmann La Roche Dérivés d'éthynyle comme modulateurs du récepteur métabotropique au glutamate
RU2745068C2 (ru) 2016-07-18 2021-03-18 Ф. Хоффманн-Ля Рош Аг Производные этинила

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1117403T3 (da) * 1998-10-02 2004-04-13 Sibia Neurosciences Inc MGLUR5-antagonister til behandling af smerte og angst
AR029803A1 (es) 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0027987D0 (en) * 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
US6910976B2 (en) 2001-06-26 2005-06-28 Stx, Llc Multi-component lacrosse stick head
GB0127430D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
GB0127433D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
EP2308870A3 (en) * 2005-06-01 2011-10-19 UCB Pharma S.A. 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses
CA2632194C (en) 2005-11-15 2012-01-03 Array Biopharma Inc. N4-phenyl-quinazoline-4-amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
MX2008016523A (es) 2006-06-30 2009-01-19 Astrazeneca Ab Derivados de pirimidina utiles en el tratamiento de cancer.
EP1972628A1 (en) 2007-03-21 2008-09-24 Schwarz Pharma Ag Indolizines and aza-analog derivatives thereof as CNS active compounds
US8076344B2 (en) * 2007-04-30 2011-12-13 Abbott Laboratories Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
EA200971143A1 (ru) 2007-06-03 2010-06-30 Вандербилт Юниверсити Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения
TW201116532A (en) * 2009-08-05 2011-05-16 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators

Also Published As

Publication number Publication date
JP2013514305A (ja) 2013-04-25
ES2551582T3 (es) 2015-11-20
MY162998A (en) 2017-07-31
CN102686589B (zh) 2014-12-10
KR101407856B1 (ko) 2014-06-16
EP2513102A1 (en) 2012-10-24
CA2780155A1 (en) 2011-06-23
CN102686589A (zh) 2012-09-19
MA33802B1 (fr) 2012-12-03
BR112012014770A2 (pt) 2016-03-29
JP5763094B2 (ja) 2015-08-12
AR079467A1 (es) 2012-01-25
PE20121443A1 (es) 2012-10-26
ZA201204429B (en) 2013-02-27
IL219371A0 (en) 2012-06-28
RU2012128551A (ru) 2014-01-27
RU2553461C2 (ru) 2015-06-20
TWI448465B (zh) 2014-08-11
US20140073638A1 (en) 2014-03-13
UA107002C2 (uk) 2014-11-10
CL2012001596A1 (es) 2013-01-04
EP2513102B1 (en) 2015-08-19
CR20120269A (es) 2012-07-04
KR20120095472A (ko) 2012-08-28
NZ599553A (en) 2014-05-30
MX2012006789A (es) 2012-07-10
AU2010332987A1 (en) 2012-06-07
AU2010332987B2 (en) 2015-08-13
US8586581B2 (en) 2013-11-19
SG181779A1 (en) 2012-07-30
CO6531478A2 (es) 2012-09-28
WO2011073172A1 (en) 2011-06-23
US8933094B2 (en) 2015-01-13
TW201144314A (en) 2011-12-16
IL219371A (en) 2015-02-26
US20110152257A1 (en) 2011-06-23
ECSP12011977A (es) 2012-07-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20181208