HK1166307A1 - Novel cyclopentane derivatives - Google Patents
Novel cyclopentane derivativesInfo
- Publication number
- HK1166307A1 HK1166307A1 HK12107019.8A HK12107019A HK1166307A1 HK 1166307 A1 HK1166307 A1 HK 1166307A1 HK 12107019 A HK12107019 A HK 12107019A HK 1166307 A1 HK1166307 A1 HK 1166307A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cyclopentane derivatives
- novel cyclopentane
- novel
- derivatives
- cyclopentane
- Prior art date
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- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07C2601/00—Systems containing only non-condensed rings
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- C07C2601/00—Systems containing only non-condensed rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- Organic Chemistry (AREA)
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- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP09162510 | 2009-06-11 | ||
PCT/EP2010/057945 WO2010142650A1 (fr) | 2009-06-11 | 2010-06-08 | Nouveaux dérivés de cyclopentane |
Publications (1)
Publication Number | Publication Date |
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HK1166307A1 true HK1166307A1 (en) | 2012-10-26 |
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HK12107019.8A HK1166307A1 (en) | 2009-06-11 | 2012-07-18 | Novel cyclopentane derivatives |
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US (1) | US7893099B2 (fr) |
EP (1) | EP2440521B1 (fr) |
JP (1) | JP5766691B2 (fr) |
KR (1) | KR101726896B1 (fr) |
CN (1) | CN102459162B (fr) |
AR (1) | AR077051A1 (fr) |
AU (1) | AU2010257586B2 (fr) |
BR (1) | BRPI1010740A2 (fr) |
CA (1) | CA2762619C (fr) |
CL (1) | CL2011003123A1 (fr) |
ES (1) | ES2466720T3 (fr) |
HK (1) | HK1166307A1 (fr) |
IL (1) | IL216448A (fr) |
MX (1) | MX2011012778A (fr) |
PE (2) | PE20151248A1 (fr) |
RU (1) | RU2572555C2 (fr) |
SG (1) | SG176780A1 (fr) |
TW (1) | TWI496575B (fr) |
WO (1) | WO2010142650A1 (fr) |
ZA (1) | ZA201109041B (fr) |
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JP6096808B2 (ja) * | 2012-02-07 | 2017-03-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規なアゼチジン誘導体 |
BR112014019220A8 (pt) * | 2012-02-17 | 2017-07-11 | Hoffmann La Roche | Novos derivados de pirrolidina |
CA2923272A1 (fr) * | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Inhibiteurs de proteases a cysteine de type cathepsines |
CA3050224A1 (fr) | 2017-01-24 | 2018-08-02 | Astellas Pharma Inc. | Compose de prolineamide substitue par un phenyldifluoromethyle |
TWI830733B (zh) * | 2018-05-11 | 2024-02-01 | 中國大陸商迪哲(江蘇)醫藥有限公司 | 環戊烷化合物 |
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Publication number | Priority date | Publication date | Assignee | Title |
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AU783145B2 (en) * | 1999-12-24 | 2005-09-29 | F. Hoffmann-La Roche Ag | Nitrile derivatives as cathepsin K inhibitors |
US6462076B2 (en) * | 2000-06-14 | 2002-10-08 | Hoffmann-La Roche Inc. | Beta-amino acid nitrile derivatives as cathepsin K inhibitors |
US6982263B2 (en) * | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
JP4343690B2 (ja) * | 2001-11-13 | 2009-10-14 | メルク フロスト カナダ リミテツド | プロテアーゼ阻害薬としてのシアノアルキルアミノ誘導体 |
SE0201977D0 (sv) | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
CN100393700C (zh) * | 2003-06-30 | 2008-06-11 | 麦克弗罗斯特(加拿大)公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
JP4769192B2 (ja) * | 2003-10-24 | 2011-09-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カテプシン阻害剤としての新規な化合物及び組成物 |
WO2006102535A2 (fr) * | 2005-03-22 | 2006-09-28 | Celera Genomics | Composes contenant du sulfonyle en tant qu'inhibiteurs de cysteine proteases |
US20070208001A1 (en) | 2006-03-03 | 2007-09-06 | Jincong Zhuo | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
JP2010531344A (ja) * | 2007-06-26 | 2010-09-24 | アストラゼネカ アクチボラグ | カテプシンk阻害剤としての1−シアノシクロプロピル誘導体 |
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2010
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- 2010-06-08 CN CN201080025400.8A patent/CN102459162B/zh not_active Expired - Fee Related
- 2010-06-08 MX MX2011012778A patent/MX2011012778A/es active IP Right Grant
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- 2010-06-08 EP EP10724803.1A patent/EP2440521B1/fr not_active Not-in-force
- 2010-06-08 ES ES10724803.1T patent/ES2466720T3/es active Active
- 2010-06-08 CA CA2762619A patent/CA2762619C/fr not_active Expired - Fee Related
- 2010-06-08 SG SG2011091436A patent/SG176780A1/en unknown
- 2010-06-08 RU RU2011153790/04A patent/RU2572555C2/ru not_active IP Right Cessation
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- 2010-06-08 PE PE2011002052A patent/PE20120537A1/es active IP Right Grant
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Also Published As
Publication number | Publication date |
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JP5766691B2 (ja) | 2015-08-19 |
PE20120537A1 (es) | 2012-05-26 |
CA2762619A1 (fr) | 2010-12-16 |
ZA201109041B (en) | 2012-08-29 |
US20100317647A1 (en) | 2010-12-16 |
AU2010257586A1 (en) | 2011-12-01 |
WO2010142650A1 (fr) | 2010-12-16 |
AR077051A1 (es) | 2011-07-27 |
US7893099B2 (en) | 2011-02-22 |
JP2012529460A (ja) | 2012-11-22 |
SG176780A1 (en) | 2012-01-30 |
RU2572555C2 (ru) | 2016-01-20 |
CL2011003123A1 (es) | 2012-07-20 |
IL216448A0 (en) | 2012-02-29 |
CN102459162A (zh) | 2012-05-16 |
EP2440521B1 (fr) | 2014-04-30 |
EP2440521A1 (fr) | 2012-04-18 |
MX2011012778A (es) | 2011-12-16 |
CA2762619C (fr) | 2017-07-11 |
AU2010257586B2 (en) | 2015-06-11 |
BRPI1010740A2 (pt) | 2016-03-15 |
CN102459162B (zh) | 2014-01-08 |
IL216448A (en) | 2014-06-30 |
TW201103543A (en) | 2011-02-01 |
PE20151248A1 (es) | 2015-08-31 |
ES2466720T3 (es) | 2014-06-11 |
KR101726896B1 (ko) | 2017-04-13 |
TWI496575B (zh) | 2015-08-21 |
KR20120034727A (ko) | 2012-04-12 |
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