HK1163160A1 - 通過細菌性來源的完整小細胞向哺乳動物細胞遞送功能性核酸 - Google Patents

通過細菌性來源的完整小細胞向哺乳動物細胞遞送功能性核酸

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Publication number
HK1163160A1
HK1163160A1 HK12103437.1A HK12103437A HK1163160A1 HK 1163160 A1 HK1163160 A1 HK 1163160A1 HK 12103437 A HK12103437 A HK 12103437A HK 1163160 A1 HK1163160 A1 HK 1163160A1
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HK
Hong Kong
Prior art keywords
derived
nucleic acids
mammalian cells
cells via
functional nucleic
Prior art date
Application number
HK12103437.1A
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English (en)
Inventor
Himanshu Brahmbhatt
Jennifer Macdiarmid
Original Assignee
Engeneic Molecular Delivery Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engeneic Molecular Delivery Pty Ltd filed Critical Engeneic Molecular Delivery Pty Ltd
Publication of HK1163160A1 publication Critical patent/HK1163160A1/zh

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HK12103437.1A 2004-08-26 2007-12-05 通過細菌性來源的完整小細胞向哺乳動物細胞遞送功能性核酸 HK1163160A1 (zh)

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HK1163160A1 true HK1163160A1 (zh) 2012-09-07

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US (11) US8691963B2 (zh)
EP (2) EP1791959A4 (zh)
JP (1) JP4965447B2 (zh)
CN (2) CN101072876B (zh)
AU (2) AU2005276145C1 (zh)
CA (1) CA2577938C (zh)
DK (1) DK2386640T3 (zh)
ES (1) ES2535235T3 (zh)
HK (1) HK1163160A1 (zh)
HU (1) HUE024999T2 (zh)
MX (1) MX2007002294A (zh)
NZ (1) NZ553910A (zh)
PL (1) PL2386640T3 (zh)
PT (1) PT2386640E (zh)
SI (1) SI2386640T1 (zh)
WO (1) WO2006021894A2 (zh)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2584305T3 (es) * 2001-10-15 2016-09-27 Engeneic Molecular Delivery Pty Ltd. Minicélulas intactas como vectores para transferencia de ADN y terapia génica in vitro e in vivo
US7611885B2 (en) 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
PL1694361T3 (pl) 2003-12-09 2011-08-31 Engeneic Molecular Delivery Pty Ltd Ukierunkowane dostarczanie genów do niefagocytujących komórek ssaczych z zastosowaniem nienaruszonych minikomórek pochodzących od bakterii
CN1925873B (zh) 2004-02-02 2011-02-09 恩杰内克分子递送有限公司 经细菌来源的完整微细胞在体外将药物靶向递送至哺乳动物细胞的组合物和方法
US8772013B2 (en) * 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
HUE024999T2 (en) 2004-08-26 2016-02-29 Engeneic Molecular Delivery Pty Ltd Introducing functional nucleic acids into mammalian cells with bacterial intact minicells
DE602005023345D1 (de) 2004-12-17 2010-10-14 Beth Israel Hospital Zusammensetzungen für bakteriell vermitteltes gen-silencing sowie verfahren zur verwendung davon
WO2008012695A2 (en) 2006-06-23 2008-01-31 Engeneic Molecular Delivery Pty Ltd. Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells
ATE485512T1 (de) * 2006-11-10 2010-11-15 Absorption Systems Group Llc Stabile zelllinien und verfahren zur beurteilung der aufnahme von chemikalien im magen-darm-trakt
ES2668963T3 (es) * 2006-12-18 2018-05-23 Exchange Imaging Technologies Gmbh Nanopartículas fluorescentes
ES2534435T3 (es) * 2007-03-30 2015-04-22 Engeneic Molecular Delivery Pty Ltd. Minicélulas intactas de origen bacteriano que encierran un ácido nucleico funcional exento de plásmido para la administración in vivo a células de mamífero
WO2008156702A2 (en) * 2007-06-15 2008-12-24 Cequent Pharmaceuticals, Inc. Bacteria mediated gene silencing
EP2212341A4 (en) * 2007-10-24 2011-09-21 Merck Sharp & Dohme NEW HIV TARGETS
CN102056631B (zh) * 2008-04-11 2014-11-12 井户川雅史 细胞凋亡诱导物
US20100112670A1 (en) 2008-06-25 2010-05-06 Vaxiion Therapeutics, Inc. Regulated genetic suicide mechanism compositions and methods
JP5527950B2 (ja) * 2008-07-16 2014-06-25 独立行政法人海洋研究開発機構 接合伝達形質転換体を製造する方法及び該方法に用いられるミニセル
JP5660537B2 (ja) * 2008-10-30 2015-01-28 国立大学法人 岡山大学 乳酸菌により二本鎖ｒｎａを生成するキット及びその利用
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2625189B1 (en) 2010-10-01 2018-06-27 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
EP3527222B1 (en) * 2011-02-15 2021-04-07 Vaxiion Therapeutics, LLC Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
HUE057725T2 (hu) 2011-10-03 2022-06-28 Modernatx Inc Módosított nukleozidok, nukleotidok és nukleinsavak és ezek felhasználása
KR102046042B1 (ko) * 2011-12-13 2019-11-18 엔진아이씨 몰레큘러 딜리버리 피티와이 리미티드 뇌종양에 대한 치료제의 전달을 위한 박테리아 유래된, 무손상 미니세포
HRP20220717T1 (hr) 2011-12-16 2022-07-22 Modernatx, Inc. Modificirani pripravci mrna
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
AU2013243947A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
AU2013327059B2 (en) 2012-10-02 2018-11-08 Vaxiion Therapeutics, Llc Immunomodulatory minicells and methods of use
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
US9006200B2 (en) 2013-03-13 2015-04-14 Asbestos Diseases Research Foundation MicroRNA-based approach to treating malignant pleural mesothelioma
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
SG11201602429QA (en) 2013-10-04 2016-04-28 Engeneic Molecular Delivery Pty Ltd Combination tumor treatment with drug-loaded, bispecific ligand-targeted minicells and interferon-gamma
WO2016051389A1 (en) 2014-10-03 2016-04-07 Engeneic Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
WO2016070045A1 (en) * 2014-10-31 2016-05-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tlr9 targeted cytotoxic agents
US10792299B2 (en) 2014-12-26 2020-10-06 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
US11045488B2 (en) 2014-12-26 2021-06-29 Nitto Denko Corporation RNA interference agents for GST-π gene modulation
US20180002702A1 (en) 2014-12-26 2018-01-04 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
WO2017024059A1 (en) 2015-08-04 2017-02-09 Vaxiion Therapeutics, Llc Ionizing irradiation sterilization of bacterial minicell-based biopharmaceuticals and methods of use
US10792374B2 (en) 2015-10-09 2020-10-06 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
ES2636646B1 (es) 2016-04-05 2018-08-03 Universidade De Santiago De Compostela NUEVOS VEHÍCULOS PARA LA TRANSFECCIÓN DE miRNAs
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
CA3039010A1 (en) 2016-10-06 2018-04-12 Engeneic Molecular Delivery Pty Ltd Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same
EP3544626A1 (en) 2016-11-23 2019-10-02 Vaxiion Therapeutics, LLC Immunomodulatory&oncolytic minicells and methods of use
AU2018256925A1 (en) 2017-04-28 2019-10-10 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
EP3688168A4 (en) 2017-09-25 2021-07-14 Agrospheres, Inc. COMPOSITIONS AND PROCESSES FOR THE PRODUCTION AND ADVANCED ADMINISTRATION OF ORGANIC PRODUCTS
CA3096448A1 (en) * 2018-04-09 2019-10-17 Orgenesis Inc. Bioxomes particles, redoxomes, method and composition
WO2020021437A1 (en) * 2018-07-23 2020-01-30 Engeneic Molecular Delivery Pty Ltd Compositions comprising bacterially derived minicells and methods of using the same
CN111228292B (zh) * 2020-03-11 2021-04-13 福州载基生物科技有限公司 人tpt1/tctp基因在制备抗肿瘤药物中的应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
US4497796A (en) * 1980-03-26 1985-02-05 The Regents Of The University Of California Gene transfer in intact mammals
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4496778A (en) 1983-10-03 1985-01-29 Exxon Research & Engineering Co. Process for the hydroxylation of olefins using molecular oxygen, an osmium containing catalyst, a copper Co-catalyst, and an aromatic amine based promoter
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE69233254T2 (de) 1991-06-14 2004-09-16 Genentech, Inc., South San Francisco Humanisierter Heregulin Antikörper
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US5866699A (en) 1994-07-18 1999-02-02 Hybridon, Inc. Oligonucleotides with anti-MDR-1 gene activity
JPH1075793A (ja) 1996-09-06 1998-03-24 Mitsui Petrochem Ind Ltd オルガネラの接合伝達形質転換法
EP0970212A1 (en) 1997-03-19 2000-01-12 ZymoGenetics, Inc. Secreted salivary zsig32 polypeptides
KR20070118315A (ko) 1999-04-21 2007-12-14 와이어쓰 폴리뉴클레오티드 서열의 기능을 억제하기 위한 조성물
PL360581A1 (en) 1999-05-11 2004-09-06 Ortho-Mcneil Pharmaceutical, Inc. Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration
CA2395320A1 (en) 1999-12-23 2001-07-05 Exiqon A/S Therapeutic uses of lna-modified oligonucleotides
US6635448B2 (en) 2000-08-21 2003-10-21 Clonexdevelopment, Inc. Methods and compositions for increasing protein yield from a cell culture
US7795232B1 (en) * 2000-08-25 2010-09-14 Genta Incorporated Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
NZ528250A (en) 2001-03-07 2006-09-29 Childrens Medical Center Method to screen peptide display libraries using minicell display
US20050153914A1 (en) * 2001-05-18 2005-07-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA)
US7011946B2 (en) 2001-05-22 2006-03-14 Trustees Of Tufts College In vivo assay for identification of antimicrobial agents
US20030194798A1 (en) * 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
ES2584305T3 (es) * 2001-10-15 2016-09-27 Engeneic Molecular Delivery Pty Ltd. Minicélulas intactas como vectores para transferencia de ADN y terapia génica in vitro e in vivo
US20030203481A1 (en) * 2002-02-25 2003-10-30 Surber Mark W. Conjugated minicells
AU2002318168B2 (en) 2002-02-25 2007-12-13 Vaxiion Therapeutics, Llc Minicell compositions and methods
US20040053289A1 (en) 2002-09-09 2004-03-18 The Regents Of The University Of California Short interfering nucleic acid hybrids and methods thereof
US20040180844A1 (en) * 2003-03-10 2004-09-16 Fesik Stephen W. Method of killing cancer cells
US7611885B2 (en) 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
JP2005034834A (ja) 2003-06-26 2005-02-10 Nitto Denko Corp クリーニング部材およびクリーニング方法
PL1694361T3 (pl) 2003-12-09 2011-08-31 Engeneic Molecular Delivery Pty Ltd Ukierunkowane dostarczanie genów do niefagocytujących komórek ssaczych z zastosowaniem nienaruszonych minikomórek pochodzących od bakterii
US8772013B2 (en) 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
CN1925873B (zh) * 2004-02-02 2011-02-09 恩杰内克分子递送有限公司 经细菌来源的完整微细胞在体外将药物靶向递送至哺乳动物细胞的组合物和方法
FR2866203B1 (fr) 2004-02-13 2006-12-08 Roquette Freres Procede de fabrication d'un produit de cuisson a base de gluten
HUE024999T2 (en) 2004-08-26 2016-02-29 Engeneic Molecular Delivery Pty Ltd Introducing functional nucleic acids into mammalian cells with bacterial intact minicells
DE602005023345D1 (de) 2004-12-17 2010-10-14 Beth Israel Hospital Zusammensetzungen für bakteriell vermitteltes gen-silencing sowie verfahren zur verwendung davon
WO2008012695A2 (en) 2006-06-23 2008-01-31 Engeneic Molecular Delivery Pty Ltd. Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells
ES2534435T3 (es) 2007-03-30 2015-04-22 Engeneic Molecular Delivery Pty Ltd. Minicélulas intactas de origen bacteriano que encierran un ácido nucleico funcional exento de plásmido para la administración in vivo a células de mamífero

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