HK1162498A1 - Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd copd 5--2- - Google Patents
Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd copd 5--2-Info
- Publication number
- HK1162498A1 HK1162498A1 HK12102965.3A HK12102965A HK1162498A1 HK 1162498 A1 HK1162498 A1 HK 1162498A1 HK 12102965 A HK12102965 A HK 12102965A HK 1162498 A1 HK1162498 A1 HK 1162498A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- copd
- pyrazolyl
- useful
- treatment
- tosylate salt
- Prior art date
Links
- DIJINXJFZUSKMG-UHFFFAOYSA-N 5-(1H-pyrazol-5-yl)-1H-pyridin-2-one Chemical class O=c1ccc(c[nH]1)-c1cc[nH]n1 DIJINXJFZUSKMG-UHFFFAOYSA-N 0.000 title 1
- 125000005490 tosylate group Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15409909P | 2009-02-20 | 2009-02-20 | |
PCT/GB2010/050271 WO2010094964A1 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1162498A1 true HK1162498A1 (en) | 2012-08-31 |
Family
ID=42046174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK12102965.3A HK1162498A1 (en) | 2009-02-20 | 2012-03-26 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd copd 5--2- |
Country Status (16)
Country | Link |
---|---|
US (2) | US8232296B2 (es) |
EP (1) | EP2398792B1 (es) |
JP (1) | JP5543982B2 (es) |
KR (1) | KR20110127158A (es) |
CN (1) | CN102405219B (es) |
AR (1) | AR075523A1 (es) |
AU (1) | AU2010215269B2 (es) |
BR (1) | BRPI1008396B8 (es) |
CA (1) | CA2752319C (es) |
ES (1) | ES2469916T3 (es) |
HK (1) | HK1162498A1 (es) |
MX (1) | MX2011008389A (es) |
RU (1) | RU2526038C2 (es) |
TW (1) | TW201036957A (es) |
UY (1) | UY32461A (es) |
WO (1) | WO2010094964A1 (es) |
Families Citing this family (24)
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SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200808763A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
US8466284B2 (en) * | 2007-11-06 | 2013-06-18 | Astra Zeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
EP2247299A4 (en) * | 2007-12-21 | 2012-06-06 | Univ Rochester | MOLECULAR TARGETS FOR THE TREATMENT OF INFLAMMATION |
TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
EP2483244A1 (en) * | 2009-10-02 | 2012-08-08 | AstraZeneca AB | 2-pyridone compounds used as inhibitors of neutrophil elastase |
US9475041B2 (en) | 2012-04-24 | 2016-10-25 | Basf Se | Zeolitic materials and methods for their preparation using alkenyltrialkylammonium compounds |
US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
EA025504B1 (ru) * | 2012-09-26 | 2016-12-30 | Далянь Инститьют Оф Кемикал Физикс, Чайниз Академи Оф Сайэнс | Молекулярное сито sapo-34 и способ его получения |
EP2902362B1 (en) * | 2012-09-26 | 2017-06-21 | Dalian Institute Of Chemical Physics, Chinese Academy of Sciences | Sapo-34 molecular sieve and synthesis method thereof |
JP6313343B2 (ja) * | 2013-03-06 | 2018-04-18 | ノバルティス アーゲー | 有機化合物の製剤 |
RU2542100C1 (ru) * | 2013-12-24 | 2015-02-20 | Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской Академии Наук (ИХС РАН) | Сокристаллическая форма теофиллина с дифлунисалом или диклофенаком |
US9221807B2 (en) * | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
JP6685314B2 (ja) * | 2015-02-12 | 2020-04-22 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | Bea骨格構造を有する脱アルミニウム化ゼオライト材料を製造する方法 |
US20160257573A1 (en) * | 2015-03-03 | 2016-09-08 | Uop Llc | High surface area pentasil zeolite and process for making same |
WO2018078097A1 (en) * | 2016-10-28 | 2018-05-03 | Astrazeneca Ab | Crystalline form of (1r,2r)-2-[4-(3-methy1-1h-pyrazol-5-yl)benzoyl]-n-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexanecarboxamide |
CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
CN112851643B (zh) * | 2019-11-28 | 2024-01-16 | 广东东阳光药业股份有限公司 | 嘧啶苯甲酰胺化合物的盐酸盐及其用途 |
EP4252850A3 (en) | 2020-04-16 | 2023-11-15 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
CN114075135A (zh) * | 2020-08-10 | 2022-02-22 | 上海润石医药科技有限公司 | 含邻氨基吡啶炔基的化合物的盐及其制备方法和应用 |
WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
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WO2009058076A1 (en) | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
US8466284B2 (en) * | 2007-11-06 | 2013-06-18 | Astra Zeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
KR101273200B1 (ko) | 2008-02-06 | 2013-06-17 | 펄마젠 쎄라퓨틱스 (시너지) 리미티드 | 화합물 |
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GB0811099D0 (en) | 2008-06-17 | 2008-07-23 | Astrazeneca Ab | New combination 376 |
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TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
-
2010
- 2010-02-12 TW TW099104696A patent/TW201036957A/zh unknown
- 2010-02-16 US US12/706,313 patent/US8232296B2/en active Active
- 2010-02-18 WO PCT/GB2010/050271 patent/WO2010094964A1/en active Application Filing
- 2010-02-18 ES ES10705178.1T patent/ES2469916T3/es active Active
- 2010-02-18 AU AU2010215269A patent/AU2010215269B2/en active Active
- 2010-02-18 AR ARP100100488A patent/AR075523A1/es unknown
- 2010-02-18 KR KR1020117019327A patent/KR20110127158A/ko not_active Application Discontinuation
- 2010-02-18 RU RU2011135627/04A patent/RU2526038C2/ru active
- 2010-02-18 CA CA2752319A patent/CA2752319C/en active Active
- 2010-02-18 BR BRPI1008396A patent/BRPI1008396B8/pt active IP Right Grant
- 2010-02-18 MX MX2011008389A patent/MX2011008389A/es active IP Right Grant
- 2010-02-18 CN CN2010800174198A patent/CN102405219B/zh active Active
- 2010-02-18 EP EP10705178.1A patent/EP2398792B1/en active Active
- 2010-02-18 JP JP2011550649A patent/JP5543982B2/ja active Active
- 2010-02-19 UY UY0001032461A patent/UY32461A/es unknown
-
2012
- 2012-03-26 HK HK12102965.3A patent/HK1162498A1/xx unknown
- 2012-06-27 US US13/534,687 patent/US20120269872A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2469916T3 (es) | 2014-06-20 |
BRPI1008396B8 (pt) | 2021-05-25 |
TW201036957A (en) | 2010-10-16 |
BRPI1008396B1 (pt) | 2020-11-10 |
CN102405219B (zh) | 2013-11-06 |
AU2010215269B2 (en) | 2013-06-27 |
WO2010094964A1 (en) | 2010-08-26 |
JP2012518623A (ja) | 2012-08-16 |
CA2752319A1 (en) | 2010-08-26 |
US8232296B2 (en) | 2012-07-31 |
AU2010215269A1 (en) | 2011-08-25 |
RU2526038C2 (ru) | 2014-08-20 |
BRPI1008396A2 (pt) | 2017-06-27 |
KR20110127158A (ko) | 2011-11-24 |
US20100216843A1 (en) | 2010-08-26 |
CN102405219A (zh) | 2012-04-04 |
UY32461A (es) | 2010-09-30 |
AR075523A1 (es) | 2011-04-06 |
EP2398792B1 (en) | 2014-04-09 |
EP2398792A1 (en) | 2011-12-28 |
MX2011008389A (es) | 2011-09-01 |
US20120269872A1 (en) | 2012-10-25 |
RU2011135627A (ru) | 2013-03-27 |
JP5543982B2 (ja) | 2014-07-09 |
CA2752319C (en) | 2016-10-04 |
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