HK1160835A1 - Nitric oxide donating prostamides - Google Patents

Nitric oxide donating prostamides

Info

Publication number
HK1160835A1
HK1160835A1 HK11113302.3A HK11113302A HK1160835A1 HK 1160835 A1 HK1160835 A1 HK 1160835A1 HK 11113302 A HK11113302 A HK 11113302A HK 1160835 A1 HK1160835 A1 HK 1160835A1
Authority
HK
Hong Kong
Prior art keywords
prostamides
nitric oxide
oxide donating
donating
nitric
Prior art date
Application number
HK11113302.3A
Other languages
English (en)
Chinese (zh)
Inventor
Francesca Benedini
Stefano Biondi
Valerio Chiroli
Wesley Kwan Mung Chong
Liming Dong
Achim Hans-Pter Krauss
Fabio Nicoli
Ganesh Prasanna
William Francois Vernier
Yi Yang
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of HK1160835A1 publication Critical patent/HK1160835A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK11113302.3A 2008-05-09 2011-12-08 Nitric oxide donating prostamides HK1160835A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5208408P 2008-05-09 2008-05-09
US13933308P 2008-12-19 2008-12-19
PCT/IB2009/005594 WO2009136281A1 (en) 2008-05-09 2009-05-11 Nitric oxide donating prostamides

Publications (1)

Publication Number Publication Date
HK1160835A1 true HK1160835A1 (en) 2012-08-17

Family

ID=41020929

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11113302.3A HK1160835A1 (en) 2008-05-09 2011-12-08 Nitric oxide donating prostamides

Country Status (9)

Country Link
US (1) US8101658B2 (de)
EP (1) EP2274279B1 (de)
JP (1) JP5401540B2 (de)
CN (1) CN102099330B (de)
AR (1) AR076731A1 (de)
CA (1) CA2723704C (de)
ES (1) ES2428387T3 (de)
HK (1) HK1160835A1 (de)
WO (1) WO2009136281A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ プロスタグランジンの精製方法
BR112013020719B1 (pt) * 2011-02-14 2018-04-17 Allergan, Inc. Composições de derivados de bimatoprost tipo éster e métodos
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
WO2016156104A1 (en) 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (de) 2015-04-30 2016-11-02 NicOx S.A. Stickoxidabgebende derivate von prostaglandinen
KR102363923B1 (ko) 2015-09-09 2022-02-21 어드밴스드 인헐레이션 테라피즈 (에이아이티) 리미티드 세기관지염이 있는 유아를 위한 산화질소 흡입 치료
MX2019005321A (es) 2016-11-08 2019-10-14 Bausch & Lomb Derivados de prostaglandina que liberan oxido nitrico para el tratamiento de glaucoma de tension normal.
HUE052204T2 (hu) 2018-02-21 2021-04-28 Nicox Sa Eljárás nitrogén-monoxidot leadó prosztaglandin analógok elõállítására
RU2718744C2 (ru) * 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
KR20210032435A (ko) * 2018-07-12 2021-03-24 니콕스 에스아 산화질소 방출 프로스타미드를 함유하는 안과용 조성물
EP3772511B1 (de) 2019-08-05 2023-11-08 Nicox S.A. Verfahren zur herstellung eines stickoxidabgebenden prostaglandinanalogs
JP2024509051A (ja) 2021-02-03 2024-02-29 ニコックス エス．エー． 一酸化窒素供与プロスタグランジン類似体の調製のための方法
CN117979973A (zh) 2021-09-20 2024-05-03 尼科斯股份有限公司 作为神经保护剂的释放一氧化氮的前列腺酰胺
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
EP4303211A1 (de) 2022-07-07 2024-01-10 Nicox S.A. Industrielles verfahren zur herstellung von hexansäure, 6(nitrooxy)-,(1s,2e)-3-[(1r,2r,3s,5r)-2-[(2z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl-ester und hochreines produkt
CN115677549A (zh) * 2022-10-27 2023-02-03 神隆医药（常熟）有限公司 一种贝美前列素手性异构体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US6395787B1 (en) * 2000-02-08 2002-05-28 Allergan Sales, Inc. Ocular hypotensive lipids
TWI298257B (en) * 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
EP1336602A1 (de) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrat-Prodrugs zur Freisetzung von Stickstoffmonoxid in kontrollierter und selektiver Weise sowie deren Verwendung zur Prävention und Behandlung inflammatorischer, ischämischer und proliferativer Erkrankungen
JP2005519115A (ja) * 2002-03-01 2005-06-30 アラーガン、インコーポレイテッド プロスタミドの製造
HUE027357T2 (en) * 2004-01-05 2016-09-28 Nicox Sa Prostaglandin nitrooxy derivatives
JP2009501150A (ja) 2005-06-29 2009-01-15 ファイザー・インク プロスタグランジン誘導体
US20070015838A1 (en) * 2005-07-14 2007-01-18 Allergan, Inc. Cyclopentane n-lower alkyl heptenamide-5-cis-2-(3alpha-hydroxy-5-phenylpentyl)-3, 5-dihydroxy, [1alpha, 2beta, 3alpha, 5alpha] compounds as agents for lowering intraocular pressure

Also Published As

Publication number Publication date
WO2009136281A1 (en) 2009-11-12
JP5401540B2 (ja) 2014-01-29
CN102099330B (zh) 2014-04-30
CA2723704A1 (en) 2009-11-12
CA2723704C (en) 2017-08-22
CN102099330A (zh) 2011-06-15
JP2011519910A (ja) 2011-07-14
EP2274279B1 (de) 2013-07-31
EP2274279A1 (de) 2011-01-19
AR076731A1 (es) 2011-07-06
ES2428387T3 (es) 2013-11-07
US20110092590A1 (en) 2011-04-21
US8101658B2 (en) 2012-01-24

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