HK1160117A1 - 生松素的兩種晶型 ，其製備及其在製造藥物組合物中的用途 - Google Patents

生松素的兩種晶型 ，其製備及其在製造藥物組合物中的用途

Info

Publication number
HK1160117A1
HK1160117A1 HK12100409.1A HK12100409A HK1160117A1 HK 1160117 A1 HK1160117 A1 HK 1160117A1 HK 12100409 A HK12100409 A HK 12100409A HK 1160117 A1 HK1160117 A1 HK 1160117A1
Authority
HK
Hong Kong
Prior art keywords
pinocembrin
crystalline
manufacture
preparation
types
Prior art date
Application number
HK12100409.1A
Other languages
English (en)
Inventor
杜冠華
吕揚
吳松
王珂
常穎
楊志宏
童元峰
高梅
Original Assignee
石藥集團中奇制藥技術 石家莊 有限公司 中國醫學科學院藥物研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 石藥集團中奇制藥技術 石家莊 有限公司 中國醫學科學院藥物研究所 filed Critical 石藥集團中奇制藥技術 石家莊 有限公司 中國醫學科學院藥物研究所
Publication of HK1160117A1 publication Critical patent/HK1160117A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
HK12100409.1A 2008-11-13 2012-01-13 生松素的兩種晶型 ，其製備及其在製造藥物組合物中的用途 HK1160117A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2008/073047 WO2010054512A1 (zh) 2008-11-13 2008-11-13 生松素化合物的两种晶型、其制备方法及其在制备药物中的应用

Publications (1)

Publication Number Publication Date
HK1160117A1 true HK1160117A1 (zh) 2012-08-10

Family

ID=42169590

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12100409.1A HK1160117A1 (zh) 2008-11-13 2012-01-13 生松素的兩種晶型 ，其製備及其在製造藥物組合物中的用途

Country Status (17)

Country Link
US (1) US8399511B2 (zh)
EP (1) EP2360152B8 (zh)
JP (1) JP5608666B2 (zh)
KR (1) KR101646805B1 (zh)
AP (1) AP2943A (zh)
AU (1) AU2008364170B2 (zh)
BR (1) BRPI0823286A2 (zh)
CA (1) CA2743618C (zh)
CU (1) CU24127B1 (zh)
EA (1) EA020224B1 (zh)
ES (1) ES2476615T3 (zh)
HK (1) HK1160117A1 (zh)
IL (1) IL212849A0 (zh)
MX (1) MX2011005024A (zh)
UA (1) UA102871C2 (zh)
WO (1) WO2010054512A1 (zh)
ZA (1) ZA201104276B (zh)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1285334C (zh) * 2004-05-12 2006-11-22 中国医学科学院药物研究所 生松素在制备防治神经细胞损伤相关疾病药物中的应用
US20090221568A1 (en) * 2005-11-04 2009-09-03 Jared Shaw Synthesis of Inhibitors of FtsZ
CN101307044B (zh) 2007-05-16 2012-07-04 中国医学科学院药物研究所 生松素化合物两种晶型和制备方法及在疾病治疗中的应用

Also Published As

Publication number Publication date
UA102871C2 (uk) 2013-08-27
KR20110082599A (ko) 2011-07-19
EA201170665A1 (ru) 2011-12-30
AU2008364170B2 (en) 2014-06-26
EP2360152B8 (en) 2014-06-11
KR101646805B1 (ko) 2016-08-08
EP2360152B1 (en) 2014-04-09
EP2360152A4 (en) 2012-05-30
AP2943A (en) 2014-07-31
ZA201104276B (en) 2012-02-29
CA2743618C (en) 2016-01-26
CU20110104A7 (es) 2012-01-31
AP2011005753A0 (en) 2011-06-30
BRPI0823286A2 (pt) 2015-06-16
MX2011005024A (es) 2011-08-17
EP2360152A1 (en) 2011-08-24
JP5608666B2 (ja) 2014-10-15
ES2476615T3 (es) 2014-07-15
AU2008364170A1 (en) 2010-05-20
WO2010054512A1 (zh) 2010-05-20
US8399511B2 (en) 2013-03-19
CU24127B1 (es) 2015-08-27
CA2743618A1 (en) 2010-05-20
US20110213024A1 (en) 2011-09-01
EA020224B1 (ru) 2014-09-30
JP2012508694A (ja) 2012-04-12
IL212849A0 (en) 2011-07-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171113