AP2943A - Two types of crystalline of pinocembrin: A and B, their preparation and their use for manufacture ofpharmaceutical compositions - Google Patents

Two types of crystalline of pinocembrin: A and B, their preparation and their use for manufacture ofpharmaceutical compositions

Info

Publication number
AP2943A
AP2943A AP2011005753A AP2011005753A AP2943A AP 2943 A AP2943 A AP 2943A AP 2011005753 A AP2011005753 A AP 2011005753A AP 2011005753 A AP2011005753 A AP 2011005753A AP 2943 A AP2943 A AP 2943A
Authority
AP
ARIPO
Prior art keywords
pinocembrin
crystalline
manufacture
preparation
types
Prior art date
Application number
AP2011005753A
Other languages
English (en)
Other versions
AP2011005753A0 (en
Inventor
Guanhua Du
Yang Lv
Song Wu
Original Assignee
Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
Inst Materia Medica Cams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd, Inst Materia Medica Cams filed Critical Cspc Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
Publication of AP2011005753A0 publication Critical patent/AP2011005753A0/xx
Application granted granted Critical
Publication of AP2943A publication Critical patent/AP2943A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
AP2011005753A 2008-11-13 2008-11-13 Two types of crystalline of pinocembrin: A and B, their preparation and their use for manufacture ofpharmaceutical compositions AP2943A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2008/073047 WO2010054512A1 (zh) 2008-11-13 2008-11-13 生松素化合物的两种晶型、其制备方法及其在制备药物中的应用

Publications (2)

Publication Number Publication Date
AP2011005753A0 AP2011005753A0 (en) 2011-06-30
AP2943A true AP2943A (en) 2014-07-31

Family

ID=42169590

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2011005753A AP2943A (en) 2008-11-13 2008-11-13 Two types of crystalline of pinocembrin: A and B, their preparation and their use for manufacture ofpharmaceutical compositions

Country Status (17)

Country Link
US (1) US8399511B2 (zh)
EP (1) EP2360152B8 (zh)
JP (1) JP5608666B2 (zh)
KR (1) KR101646805B1 (zh)
AP (1) AP2943A (zh)
AU (1) AU2008364170B2 (zh)
BR (1) BRPI0823286A2 (zh)
CA (1) CA2743618C (zh)
CU (1) CU24127B1 (zh)
EA (1) EA020224B1 (zh)
ES (1) ES2476615T3 (zh)
HK (1) HK1160117A1 (zh)
IL (1) IL212849A0 (zh)
MX (1) MX2011005024A (zh)
UA (1) UA102871C2 (zh)
WO (1) WO2010054512A1 (zh)
ZA (1) ZA201104276B (zh)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007056188A1 (en) * 2005-11-04 2007-05-18 President And Fellows Of Harvard College Synthesis of inhibitors of ftsz

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1285334C (zh) * 2004-05-12 2006-11-22 中国医学科学院药物研究所 生松素在制备防治神经细胞损伤相关疾病药物中的应用
CN101307044B (zh) 2007-05-16 2012-07-04 中国医学科学院药物研究所 生松素化合物两种晶型和制备方法及在疾病治疗中的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007056188A1 (en) * 2005-11-04 2007-05-18 President And Fellows Of Harvard College Synthesis of inhibitors of ftsz

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OTTO RICHARD GOTTLIEB ET AL.: 'The Chemistry of Rosewood. II. Isolation and Identification of Cotoin and Pinocembrin' JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 80, no. 9, 05 May 1958, ISSN 0002-7863 pages 2263 - 2265 *
THAWORN JAIPETCH ET AL.: 'Constituents of Boesenbergia pandurata(syn. Kaempferia pandurata): Isolation, Crystal Structure and Synthesis of (±)-Boesenbergin A' AUST. J. CHEM. vol. 35, 1982, pages 351 - 361 *

Also Published As

Publication number Publication date
MX2011005024A (es) 2011-08-17
KR101646805B1 (ko) 2016-08-08
US20110213024A1 (en) 2011-09-01
AU2008364170A1 (en) 2010-05-20
WO2010054512A1 (zh) 2010-05-20
EP2360152B1 (en) 2014-04-09
CU20110104A7 (es) 2012-01-31
UA102871C2 (uk) 2013-08-27
AP2011005753A0 (en) 2011-06-30
EP2360152A4 (en) 2012-05-30
BRPI0823286A2 (pt) 2015-06-16
EP2360152B8 (en) 2014-06-11
CA2743618C (en) 2016-01-26
CU24127B1 (es) 2015-08-27
EA020224B1 (ru) 2014-09-30
KR20110082599A (ko) 2011-07-19
CA2743618A1 (en) 2010-05-20
ES2476615T3 (es) 2014-07-15
JP2012508694A (ja) 2012-04-12
JP5608666B2 (ja) 2014-10-15
EA201170665A1 (ru) 2011-12-30
HK1160117A1 (zh) 2012-08-10
EP2360152A1 (en) 2011-08-24
ZA201104276B (en) 2012-02-29
IL212849A0 (en) 2011-07-31
US8399511B2 (en) 2013-03-19
AU2008364170B2 (en) 2014-06-26

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