HK1159103A1 - 製備 α， α， *， -二氟苯基 -環丙氨基 丙硫基 -三唑並 嘧啶- -基 -羥乙氧基 環戊烷- -二醇的方法及其中間體 - Google Patents

製備 α， α， *， -二氟苯基 -環丙氨基 丙硫基 -三唑並 嘧啶- -基 -羥乙氧基 環戊烷- -二醇的方法及其中間體

Info

Publication number
HK1159103A1
HK1159103A1 HK11113635.1A HK11113635A HK1159103A1 HK 1159103 A1 HK1159103 A1 HK 1159103A1 HK 11113635 A HK11113635 A HK 11113635A HK 1159103 A1 HK1159103 A1 HK 1159103A1
Authority
HK
Hong Kong
Prior art keywords
beta
alpha
cyclopropylamino
propylthio
triazolo
Prior art date
Application number
HK11113635.1A
Other languages
English (en)
Inventor
Rhony Aufdenblatten
Martin Hans Bohlin
Helena Hellstrm
Peter W Johansson
Ulf G Larsson
Mikaela Recknagel
Ursula Heiress Of Weiss Andreas Weiss
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42005334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1159103(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1159103A1 publication Critical patent/HK1159103A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
HK11113635.1A 2008-09-09 2011-12-16 製備 α， α， *， -二氟苯基 -環丙氨基 丙硫基 -三唑並 嘧啶- -基 -羥乙氧基 環戊烷- -二醇的方法及其中間體 HK1159103A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9534108P 2008-09-09 2008-09-09
PCT/SE2009/050999 WO2010030224A1 (en) 2008-09-09 2009-09-08 A process for preparing [1s- [1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates

Publications (1)

Publication Number Publication Date
HK1159103A1 true HK1159103A1 (zh) 2012-07-27

Family

ID=42005334

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11113635.1A HK1159103A1 (zh) 2008-09-09 2011-12-16 製備 α， α， *， -二氟苯基 -環丙氨基 丙硫基 -三唑並 嘧啶- -基 -羥乙氧基 環戊烷- -二醇的方法及其中間體

Country Status (20)

Country Link
US (1) US8563755B2 (zh)
EP (1) EP2340252B1 (zh)
JP (1) JP5656837B2 (zh)
KR (1) KR101669297B1 (zh)
CN (1) CN102149716A (zh)
AU (1) AU2009292269B2 (zh)
BR (1) BRPI0918038B1 (zh)
CA (1) CA2734454C (zh)
CL (1) CL2011000496A1 (zh)
DK (1) DK2340252T3 (zh)
ES (1) ES2558843T3 (zh)
HK (1) HK1159103A1 (zh)
HR (1) HRP20160018T1 (zh)
IL (1) IL211191A (zh)
MX (1) MX2011002505A (zh)
MY (1) MY156796A (zh)
RU (1) RU2509082C2 (zh)
SG (1) SG196805A1 (zh)
SI (1) SI2340252T1 (zh)
WO (1) WO2010030224A1 (zh)

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WO2013060837A1 (en) 2011-10-27 2013-05-02 Lek Pharmaceuticals D.D. Synthesis of triazolopyrimidine compounds
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EP2607355A1 (en) * 2011-12-23 2013-06-26 LEK Pharmaceuticals d.d. Synthesis of triazolopyrimidine compounds
IN2014KN01491A (zh) 2011-12-23 2015-10-23 Lek Pharmaceuticals
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CN103626743B (zh) * 2012-08-23 2018-06-08 广东东阳光药业有限公司 替卡格雷的新型中间体及其制备方法
WO2014083139A1 (en) 2012-11-29 2014-06-05 Actavis Group Ptc Ehf Novel amorphous form of ticagrelor
WO2014102830A1 (en) * 2012-12-31 2014-07-03 Megafine Pharma (P) Ltd. A process for preparation of ticagrelor and intermediates thereof
CN103965198A (zh) * 2013-02-05 2014-08-06 郝聪梅 替卡格雷的中间体及其制备方法以及利用该中间体制备替卡格雷的方法
CN104045620B (zh) * 2013-03-12 2017-05-10 博瑞生物医药（苏州）股份有限公司 一种替卡格雷中间体的制备方法
CN104098553B (zh) * 2013-04-10 2017-11-28 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
CN104211704B (zh) * 2013-06-03 2017-08-25 杭州领业医药科技有限公司 结晶形态的三唑[4,5‑d]嘧啶化合物及其制备方法和用途
CN104230818B (zh) * 2013-06-06 2018-01-12 郝聪梅 替卡格雷中间体的改进制备方法
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
CN103275087A (zh) * 2013-06-28 2013-09-04 南京工业大学 一种三氮唑并嘧啶类衍生物及其制备方法
CN104059069B (zh) * 2013-08-22 2016-08-10 北京康立生医药技术开发有限公司 一种替卡格雷的制备方法
WO2015037016A2 (en) * 2013-09-10 2015-03-19 Laurus Labs Private Limited An improved process for the preparation of ticagrelor and intermediates thereof
CN104592237A (zh) * 2013-10-31 2015-05-06 徐州万邦金桥制药有限公司 一种抗凝血药替格瑞洛的合成方法
CN103588712B (zh) * 2013-11-08 2016-06-08 南京欧信医药技术有限公司 一种嘧啶类化合物及其制备方法、和应用
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
CN103992277A (zh) * 2014-05-16 2014-08-20 苏州天马精细化学品股份有限公司 一种替卡格雷中间体4,6-二氯-5-氨基-2-丙硫基嘧啶的制备方法
US10011605B2 (en) 2014-06-18 2018-07-03 Flamma Spa Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds
CN104311560B (zh) * 2014-09-16 2017-04-26 北京红太阳药业有限公司 一种替格瑞洛的制备方法
CN104788458A (zh) * 2015-03-21 2015-07-22 北京工业大学 一种替格瑞洛的制备方法
CN105294573B (zh) * 2015-06-16 2018-07-10 厦门医学院 一种合成4,6-二氯-2-(丙硫基)-5-氨基嘧啶的方法
CN105153167B (zh) * 2015-09-06 2017-09-19 惠州信立泰药业有限公司 一种替格瑞洛结晶及含有该结晶的药物组合物
CN105237540B (zh) * 2015-09-21 2017-10-03 南京正大天晴制药有限公司 一种替格瑞洛有关物质的制备方法、检测方法及用途
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CN106866682A (zh) * 2017-04-14 2017-06-20 上海华源医药科技发展有限公司 一种适用于替格瑞洛工业化生产的工艺
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Also Published As

Publication number Publication date
BRPI0918038B1 (pt) 2021-07-13
JP5656837B2 (ja) 2015-01-21
IL211191A0 (en) 2011-04-28
EP2340252A1 (en) 2011-07-06
BRPI0918038A2 (pt) 2015-08-04
WO2010030224A1 (en) 2010-03-18
RU2509082C2 (ru) 2014-03-10
IL211191A (en) 2015-07-30
SI2340252T1 (sl) 2016-02-29
CN102149716A (zh) 2011-08-10
HRP20160018T1 (hr) 2016-02-12
SG196805A1 (en) 2014-02-13
CA2734454A1 (en) 2010-03-18
CL2011000496A1 (es) 2011-08-26
RU2011109436A (ru) 2012-10-20
US20120101274A1 (en) 2012-04-26
MY156796A (en) 2016-03-31
AU2009292269A1 (en) 2010-03-18
CA2734454C (en) 2016-09-13
ES2558843T3 (es) 2016-02-09
EP2340252A4 (en) 2012-08-01
DK2340252T3 (en) 2016-01-18
KR101669297B1 (ko) 2016-10-25
MX2011002505A (es) 2011-04-07
JP2012502024A (ja) 2012-01-26
KR20110063460A (ko) 2011-06-10
AU2009292269B2 (en) 2012-11-01
EP2340252B1 (en) 2015-11-11
US8563755B2 (en) 2013-10-22

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