HK1158212A1 - Tgr5 modulators and methods of use thereof tgr5 - Google Patents

Tgr5 modulators and methods of use thereof tgr5

Info

Publication number
HK1158212A1
HK1158212A1 HK11112785.1A HK11112785A HK1158212A1 HK 1158212 A1 HK1158212 A1 HK 1158212A1 HK 11112785 A HK11112785 A HK 11112785A HK 1158212 A1 HK1158212 A1 HK 1158212A1
Authority
HK
Hong Kong
Prior art keywords
tgr5
methods
modulators
tgr5 modulators
Prior art date
Application number
HK11112785.1A
Other languages
English (en)
Chinese (zh)
Inventor
Roberto Pellicciari
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40433897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1158212(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of HK1158212A1 publication Critical patent/HK1158212A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
HK11112785.1A 2008-07-30 2011-11-24 Tgr5 modulators and methods of use thereof tgr5 HK1158212A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08013676 2008-07-30
PCT/US2009/052290 WO2010014836A2 (en) 2008-07-30 2009-07-30 Tgr5 modulators and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1158212A1 true HK1158212A1 (en) 2012-07-13

Family

ID=40433897

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11112785.1A HK1158212A1 (en) 2008-07-30 2011-11-24 Tgr5 modulators and methods of use thereof tgr5
HK16105167.8A HK1217335A1 (zh) 2008-07-30 2016-05-05 調節劑及其使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16105167.8A HK1217335A1 (zh) 2008-07-30 2016-05-05 調節劑及其使用方法

Country Status (9)

Country Link
US (2) US8796249B2 (ru)
EP (1) EP2324046B1 (ru)
CN (2) CN105037476B (ru)
AU (1) AU2009276507B2 (ru)
BR (1) BRPI0916735B8 (ru)
CA (1) CA2732323C (ru)
EA (1) EA020310B1 (ru)
HK (2) HK1158212A1 (ru)
WO (1) WO2010014836A2 (ru)

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ES2655034T3 (es) * 2012-10-26 2018-02-16 Intercept Pharmaceuticals, Inc. Proceso para preparar derivados del ácido biliar
AU2013352288B2 (en) * 2012-11-28 2017-11-23 Intercept Pharmaceuticals, Inc. Treatment of pulmonary disease
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CN105593237B (zh) 2013-08-01 2019-06-04 美国卫生和人力服务部 法尼醇x受体的抑制剂和在医学中的用途
JP6621409B2 (ja) 2013-11-22 2019-12-18 ミナ セラピューティクス リミテッド Ｃ／ＥＢＰα小分子活性化ＲＮＡ組成物
US10000527B2 (en) 2013-12-12 2018-06-19 Council Of Scientific And Industrial Research 11-substituted bile acid derivatives, process for the preparation thereof and use of these compounds as medicaments
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WO2016079520A1 (en) * 2014-11-19 2016-05-26 Dextra Laboratories Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
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US10364267B2 (en) 2016-02-23 2019-07-30 Enanta Pharmaceuticals, Inc. Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
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WO2018152171A1 (en) 2017-02-14 2018-08-23 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr agonists and methods of use thereof
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Also Published As

Publication number Publication date
US20160052956A1 (en) 2016-02-25
US20110172198A1 (en) 2011-07-14
BRPI0916735B8 (pt) 2021-05-25
AU2009276507A1 (en) 2010-02-04
EP2324046B1 (en) 2014-09-03
EP2324046A2 (en) 2011-05-25
EA201170276A1 (ru) 2011-10-31
CA2732323A1 (en) 2010-02-04
US8796249B2 (en) 2014-08-05
WO2010014836A3 (en) 2010-04-01
CA2732323C (en) 2017-06-27
CN105037476A (zh) 2015-11-11
HK1217335A1 (zh) 2017-01-06
CN102164940A (zh) 2011-08-24
AU2009276507B2 (en) 2015-11-19
US9540414B2 (en) 2017-01-10
WO2010014836A2 (en) 2010-02-04
EA020310B1 (ru) 2014-10-30
BRPI0916735B1 (pt) 2020-07-28
CN105037476B (zh) 2018-06-12
BRPI0916735A2 (pt) 2015-11-03
CN102164940B (zh) 2015-08-19

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220730