HK1157345A1 - Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors - Google Patents

Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Info

Publication number
HK1157345A1
HK1157345A1 HK11111868.3A HK11111868A HK1157345A1 HK 1157345 A1 HK1157345 A1 HK 1157345A1 HK 11111868 A HK11111868 A HK 11111868A HK 1157345 A1 HK1157345 A1 HK 1157345A1
Authority
HK
Hong Kong
Prior art keywords
tumors
treatment
tyrosine kinase
kinase modulators
dihydropyrazole derivatives
Prior art date
Application number
HK11111868.3A
Other languages
English (en)
Inventor
Dieter Dorsch
Oliver Schadt
Frank Stieber
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HK1157345A1 publication Critical patent/HK1157345A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK11111868.3A 2008-05-29 2011-11-03 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors HK1157345A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008025750A DE102008025750A1 (de) 2008-05-29 2008-05-29 Dihydropyrazolderivate
PCT/EP2009/003030 WO2009143945A1 (de) 2008-05-29 2009-04-24 Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
HK1157345A1 true HK1157345A1 (en) 2012-06-29

Family

ID=40822993

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11111868.3A HK1157345A1 (en) 2008-05-29 2011-11-03 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Country Status (17)

Country Link
US (1) US8404685B2 (es)
EP (1) EP2300434B1 (es)
JP (1) JP5643192B2 (es)
KR (1) KR20110010821A (es)
CN (1) CN102046605B (es)
AR (1) AR071951A1 (es)
AU (1) AU2009253432B2 (es)
BR (1) BRPI0912970A2 (es)
CA (1) CA2726009C (es)
DE (1) DE102008025750A1 (es)
EA (1) EA018394B1 (es)
ES (1) ES2507573T3 (es)
HK (1) HK1157345A1 (es)
IL (1) IL209418A (es)
MX (1) MX2010012804A (es)
WO (1) WO2009143945A1 (es)
ZA (1) ZA201009085B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2837524C (en) * 2011-07-01 2019-08-20 Merck Patent Gmbh Dihydropyrazoles
ES2589558T3 (es) * 2012-07-10 2016-11-15 Ares Trading S.A. Derivados de pirimidin pirazolilo
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
EP0880508B1 (en) 1996-02-13 2003-04-16 AstraZeneca AB Quinazoline derivatives as vegf inhibitors
IL125954A (en) 1996-03-05 2003-06-24 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
JP2003535078A (ja) 2000-05-31 2003-11-25 アストラゼネカ アクチボラグ 血管損傷活性のあるインドール誘導体
BR0112224A (pt) 2000-07-07 2003-06-10 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
WO2002008213A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
JP4399269B2 (ja) * 2002-03-08 2010-01-13 メルク エンド カムパニー インコーポレーテッド 有糸分裂性キネシン阻害薬
DE102005038537A1 (de) * 2005-08-16 2007-02-22 Merck Patent Gmbh 1-Acyldihydropyrazolderivate

Also Published As

Publication number Publication date
ZA201009085B (en) 2011-10-26
US8404685B2 (en) 2013-03-26
AR071951A1 (es) 2010-07-28
EP2300434B1 (de) 2014-07-23
EP2300434A1 (de) 2011-03-30
CN102046605A (zh) 2011-05-04
JP5643192B2 (ja) 2014-12-17
IL209418A0 (en) 2011-01-31
KR20110010821A (ko) 2011-02-07
EA201001831A1 (ru) 2011-06-30
AU2009253432A1 (en) 2009-12-03
IL209418A (en) 2015-09-24
CA2726009C (en) 2016-08-23
DE102008025750A1 (de) 2009-12-03
WO2009143945A1 (de) 2009-12-03
EA018394B1 (ru) 2013-07-30
CA2726009A1 (en) 2009-12-03
ES2507573T3 (es) 2014-10-15
MX2010012804A (es) 2010-12-07
BRPI0912970A2 (pt) 2015-10-13
CN102046605B (zh) 2013-09-18
US20110071153A1 (en) 2011-03-24
AU2009253432B2 (en) 2013-08-01
JP2011520996A (ja) 2011-07-21

Similar Documents

Publication Publication Date Title
HK1222124A1 (zh) 用於實體腫瘤的治療的布魯頓酪氨酸激酶的抑制劑
IL202505A0 (en) 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumors
SI2120932T1 (sl) Indazolni derivati kot kinazni inhibitorji za zdravljenje raka
ZA201201627B (en) Compounds as tyrosine kinase modulators
HRP20150692T8 (en) Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases
HUE043569T2 (hu) Vegyületek rák kezelésére
EP2063897A4 (en) KINASEHEMMER FOR THE TREATMENT OF PROLIFERATIVE DISEASES
EP2063896A4 (en) KINASEHEMMER FOR THE TREATMENT OF PROLIFERATIVE DISEASES
IL195152A0 (en) Use of syk tyrosine kinase inhibitors for the treatment of cell proliferative disorders
HK1159989A1 (en) Bicyclic triazole derivatives for treating tumors
HRP20130423T1 (en) Pyrimidine- and triazine-sulfonamide derivatives as bradykinin b1 receptor (b1r) inhibitors for the treatment of pain
AP2886A (en) 6.7-Dialkoxy quinazoline derivatives useful for treatment of cancer related disorders
EP2331520A4 (en) ROSAMINE DERIVATIVES AS AGENTS FOR CANCER TREATMENT
IL209840A0 (en) Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors
ZA201003425B (en) 5-cyano-thienopyridines for the treatment of tumors
EP2247185A4 (en) INHIBITORS OF TYROSINE KINASE
IL210066A0 (en) Novel ortho-aminoanilides for the treatment of cancer
PL2331092T3 (pl) Sposoby i kompozycje do podawania 3-halopirogronianiu i związków pochodnych w leczeniu nowotworu
HK1157345A1 (en) Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors
ZA201007729B (en) Use of corticotropin-releasing factor for the treatment of cancer

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180424