HK115393A - Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infections - Google Patents
Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infectionsInfo
- Publication number
- HK115393A HK115393A HK1153/93A HK115393A HK115393A HK 115393 A HK115393 A HK 115393A HK 1153/93 A HK1153/93 A HK 1153/93A HK 115393 A HK115393 A HK 115393A HK 115393 A HK115393 A HK 115393A
- Authority
- HK
- Hong Kong
- Prior art keywords
- fungal infections
- systemic fungal
- vesicles
- treatment
- particles encapsulating
- Prior art date
Links
- 206010017533 Fungal infection Diseases 0.000 title abstract 3
- 208000031888 Mycoses Diseases 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 3
- 230000009885 systemic effect Effects 0.000 title abstract 3
- 150000003904 phospholipids Chemical class 0.000 title abstract 2
- 239000002459 polyene antibiotic agent Substances 0.000 title 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 3
- 229940121375 antifungal agent Drugs 0.000 abstract 3
- 230000003115 biocidal effect Effects 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000004291 polyenes Chemical class 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960000988 nystatin Drugs 0.000 abstract 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89906486A | 1986-08-21 | 1986-08-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK115393A true HK115393A (en) | 1993-11-05 |
Family
ID=25410437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK1153/93A HK115393A (en) | 1986-08-21 | 1993-10-28 | Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infections |
Country Status (14)
Country | Link |
---|---|
US (1) | US5874104A (no) |
EP (1) | EP0260811B1 (no) |
JP (1) | JPH0615475B2 (no) |
KR (1) | KR950013747B1 (no) |
AT (1) | ATE66597T1 (no) |
AU (1) | AU606880B2 (no) |
CA (1) | CA1292184C (no) |
DE (1) | DE3772498D1 (no) |
DK (1) | DK168982B1 (no) |
ES (1) | ES2051740T3 (no) |
GR (1) | GR3002852T3 (no) |
HK (1) | HK115393A (no) |
IE (1) | IE60901B1 (no) |
NO (1) | NO174833C (no) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
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CA1338736C (fr) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation |
FR2620028B2 (fr) * | 1986-12-05 | 1994-02-25 | Ire Celltarg Sa | Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant |
US4812312A (en) * | 1987-03-03 | 1989-03-14 | Board Of Regents Of The University Of Texas System | Liposome-incorporated nystatin |
US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
CA1338702C (en) * | 1987-03-05 | 1996-11-12 | Lawrence D. Mayer | High drug:lipid formulations of liposomal- antineoplastic agents |
US4999199A (en) * | 1988-11-10 | 1991-03-12 | Board Of Regents, The University Of Texas System | Pharmaceutical formulations: liposomes incorporating aromatic polyene antibiotics |
KR0151704B1 (ko) * | 1989-11-27 | 1998-10-15 | 아만 히데아키 | 지방 유제 |
WO1992011841A1 (en) * | 1991-01-14 | 1992-07-23 | Board Of Regents, The University Of Texas | Anti-hiv activity of liposomal nystatin and amphotericin b |
CA2120917A1 (en) * | 1991-10-25 | 1993-04-29 | Kazumi Ogata | External preparation for treating hemorrhoidal diseases |
JP2915296B2 (ja) * | 1993-08-30 | 1999-07-05 | 宇野 潤 | 抗真菌製剤 |
GB9519654D0 (en) * | 1995-09-27 | 1995-11-29 | Nycomed Imaging As | Stabilised phospholipid compositions |
CZ234898A3 (cs) * | 1996-01-25 | 1998-11-11 | Schering Aktiengesellschaft | Zdokonalené koncentrované injekční a infusní roztoky pro intravazální použití |
GB9721901D0 (en) * | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
AU1350099A (en) * | 1997-12-01 | 1999-06-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Formulations for topical treatment of skin infections |
IT1301807B1 (it) * | 1998-06-25 | 2000-07-07 | Tiberio Bruzzese | Formulazioni farmaceutiche iniettabili di derivati della partricina. |
US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
US6413537B1 (en) | 2000-03-10 | 2002-07-02 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
JP4786041B2 (ja) * | 2001-03-02 | 2011-10-05 | 丸善製薬株式会社 | 渋味、収斂味を低減する方法および渋味、収斂味低減ハス胚芽抽出物製剤 |
US7651689B2 (en) * | 2002-11-15 | 2010-01-26 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of applying ionization radiation for therapy of infections |
US20090099031A1 (en) * | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
EP1929073A4 (en) * | 2005-09-27 | 2010-03-10 | Amunix Inc | PROTEIN MEDICAMENT AND ITS USE |
US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
EP1956906A4 (en) | 2005-11-09 | 2009-12-30 | Combinatorx Inc | METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES |
EP3363455A1 (en) | 2005-12-30 | 2018-08-22 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for improved cardiac function |
US8933197B2 (en) * | 2007-08-15 | 2015-01-13 | Amunix Operating Inc. | Compositions comprising modified biologically active polypeptides |
MX2010009765A (es) | 2008-03-06 | 2013-07-12 | Anacor Pharmaceuticals Inc | Moleculas pequeñas que contienen boro como agentes anti-inflamatorios. |
WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
AU2010258898B8 (en) | 2009-06-08 | 2015-02-05 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
EA030619B1 (ru) | 2009-06-08 | 2018-09-28 | Амуникс Оперейтинг Инк. | Гибридный белок, включающий последовательности гормона роста и xten, способ его получения и применения |
CA2767646C (en) | 2009-07-10 | 2019-01-29 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
RU2481100C2 (ru) * | 2009-10-16 | 2013-05-10 | Лайфкеа Инновейшнз Пвт. Лтд. | Новая лекарственная форма для лечения грибковой инфекции |
CA2778678A1 (en) | 2009-10-30 | 2011-05-05 | Cns Therapeutics, Inc. | Improved neurturin molecules |
JP6200648B2 (ja) | 2009-12-18 | 2017-09-20 | アケリオス セラピューティクス,インコーポレーテッド | 三叉神経・自律神経性頭痛、片頭痛、および血管症状の治療および予防のための組成物 |
WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
US9757462B2 (en) | 2010-11-19 | 2017-09-12 | Sapporo Medical University | Combined pharmaceutical preparation |
EP2822577B1 (en) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
LT2814840T (lt) | 2012-02-15 | 2020-02-25 | Bioverativ Therapeutics Inc. | Faktoriaus viii kompozicijos ir jų gavimo ir naudojimo būdai |
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AU2015236106A1 (en) | 2014-03-25 | 2016-10-20 | The Government Of The United States Of America As Represented By The Secretary Of The Army | Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (MPLA)-containing liposome composition and a saponin |
US20170266106A1 (en) | 2014-12-01 | 2017-09-21 | Achelios Therapeutics, Inc. | Methods and compositions for treating migraine and conditions associated with pain |
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CA2994545A1 (en) | 2015-08-03 | 2017-02-09 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
SG11201803594TA (en) | 2015-11-06 | 2018-05-30 | Adjuvance Technologies Inc | Triterpene saponin analogues |
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EP3645546A4 (en) | 2017-06-30 | 2021-12-01 | Solstice Biologics, Ltd. | CHIRAL PHOSPHORAMIDITIS AUXILIARIES AND THEIR METHODS OF USE |
CA3075822A1 (en) | 2017-10-16 | 2019-04-25 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
AU2019270184A1 (en) | 2018-05-18 | 2020-11-26 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia A |
BR112021017809A2 (pt) | 2019-03-11 | 2021-11-23 | Nocion Therapeutics Inc | Bloqueadores de canais iônicos substituídos por éster e métodos para uso |
CN113811305A (zh) | 2019-03-11 | 2021-12-17 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
WO2020185830A1 (en) | 2019-03-11 | 2020-09-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
JP7513713B2 (ja) | 2019-11-06 | 2024-07-09 | ノシオン セラピューティクス,インコーポレイテッド | 荷電したイオンチャンネル遮断薬および使用方法 |
BR112022008575A2 (pt) | 2019-11-06 | 2022-08-09 | Nocion Therapeutics Inc | Bloqueadores de canal iônico carregado e métodos para uso |
AU2021236130A1 (en) | 2020-03-11 | 2022-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
WO2023175454A1 (en) | 2022-03-14 | 2023-09-21 | Pfizer Inc. | Methods for producing an adjuvant |
WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4310505A (en) * | 1979-11-08 | 1982-01-12 | California Institute Of Technology | Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances |
US4497791A (en) * | 1983-02-10 | 1985-02-05 | Vestar Research Incorporated | Method for labeling phagocytic cells |
GB2135647A (en) * | 1983-02-15 | 1984-09-05 | Squibb & Sons Inc | Method of preparing liposomes and products produced thereby |
PT78628B (en) * | 1984-05-02 | 1986-06-18 | Liposome Co Inc | Pharmaceutical composition with reduced toxicity |
US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
CA1298548C (en) * | 1984-10-22 | 1992-04-07 | Cary Arnet Presant | Method of delivering micellular particles encapsulating imaging and chemotherapeutic agents to tumors in a body |
US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
US4766046A (en) * | 1985-09-27 | 1988-08-23 | Liposome Technology, Inc. | Stabilized liposome/amphotericin composition and method |
US4812312A (en) * | 1987-03-03 | 1989-03-14 | Board Of Regents Of The University Of Texas System | Liposome-incorporated nystatin |
-
1987
- 1987-08-11 IE IE214887A patent/IE60901B1/en not_active IP Right Cessation
- 1987-08-14 DE DE8787307221T patent/DE3772498D1/de not_active Expired - Lifetime
- 1987-08-14 ES ES87307221T patent/ES2051740T3/es not_active Expired - Lifetime
- 1987-08-14 EP EP87307221A patent/EP0260811B1/en not_active Expired - Lifetime
- 1987-08-14 AT AT87307221T patent/ATE66597T1/de not_active IP Right Cessation
- 1987-08-18 AU AU77160/87A patent/AU606880B2/en not_active Expired
- 1987-08-19 NO NO873492A patent/NO174833C/no not_active IP Right Cessation
- 1987-08-19 CA CA000544830A patent/CA1292184C/en not_active Expired - Lifetime
- 1987-08-20 DK DK434187A patent/DK168982B1/da not_active IP Right Cessation
- 1987-08-20 KR KR1019870009101A patent/KR950013747B1/ko not_active IP Right Cessation
- 1987-08-21 JP JP62208049A patent/JPH0615475B2/ja not_active Expired - Fee Related
-
1991
- 1991-10-08 GR GR91401494T patent/GR3002852T3/el unknown
-
1993
- 1993-10-28 HK HK1153/93A patent/HK115393A/xx not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/467,864 patent/US5874104A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0615475B2 (ja) | 1994-03-02 |
NO873492D0 (no) | 1987-08-19 |
GR3002852T3 (en) | 1993-01-25 |
EP0260811B1 (en) | 1991-08-28 |
US5874104A (en) | 1999-02-23 |
JPS6366123A (ja) | 1988-03-24 |
IE872148L (en) | 1988-02-21 |
DE3772498D1 (de) | 1991-10-02 |
EP0260811A2 (en) | 1988-03-23 |
IE60901B1 (en) | 1994-08-24 |
DK434187D0 (da) | 1987-08-20 |
DK168982B1 (da) | 1994-07-25 |
ATE66597T1 (de) | 1991-09-15 |
CA1292184C (en) | 1991-11-19 |
KR950013747B1 (ko) | 1995-11-15 |
EP0260811A3 (en) | 1988-07-20 |
AU606880B2 (en) | 1991-02-21 |
KR880002531A (ko) | 1988-05-09 |
ES2051740T3 (es) | 1994-07-01 |
DK434187A (da) | 1988-02-22 |
AU7716087A (en) | 1988-02-25 |
NO174833C (no) | 1994-07-20 |
NO174833B (no) | 1994-04-11 |
NO873492L (no) | 1988-02-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20070813 |