HK1148529A1 - 激酶抑制劑的組合物及其在治療癌症和其它與激酶相關的疾病中的用途 - Google Patents

激酶抑制劑的組合物及其在治療癌症和其它與激酶相關的疾病中的用途

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Publication number
HK1148529A1
HK1148529A1 HK11102786.1A HK11102786A HK1148529A1 HK 1148529 A1 HK1148529 A1 HK 1148529A1 HK 11102786 A HK11102786 A HK 11102786A HK 1148529 A1 HK1148529 A1 HK 1148529A1
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HK
Hong Kong
Prior art keywords
kinases
cancer
compositions
treatment
kinase inhibitors
Prior art date
Application number
HK11102786.1A
Other languages
English (en)
Inventor
Chiang Jia Li
Ji-Feng Liu
Youzhi Li
Wei Li
Harry Rogoff
Original Assignee
1Globe Biomedical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 1Globe Biomedical Co Ltd filed Critical 1Globe Biomedical Co Ltd
Publication of HK1148529A1 publication Critical patent/HK1148529A1/zh

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Rheumatology (AREA)
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  • Communicable Diseases (AREA)
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  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
HK11102786.1A 2007-09-06 2011-03-21 激酶抑制劑的組合物及其在治療癌症和其它與激酶相關的疾病中的用途 HK1148529A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97041007P 2007-09-06 2007-09-06
US1338907P 2007-12-13 2007-12-13
US7429508P 2008-06-20 2008-06-20
PCT/US2008/075418 WO2009033033A2 (en) 2007-09-06 2008-09-05 Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases

Publications (1)

Publication Number Publication Date
HK1148529A1 true HK1148529A1 (zh) 2011-09-09

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Application Number Title Priority Date Filing Date
HK11102786.1A HK1148529A1 (zh) 2007-09-06 2011-03-21 激酶抑制劑的組合物及其在治療癌症和其它與激酶相關的疾病中的用途
HK16114487A HK1226071A1 (zh) 2007-09-06 2016-12-20 激酶抑制劑的組合物及其在治療癌症與其與激酶相關的疾病中的用途

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HK16114487A HK1226071A1 (zh) 2007-09-06 2016-12-20 激酶抑制劑的組合物及其在治療癌症與其與激酶相關的疾病中的用途

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US (5) US8299106B2 (zh)
EP (2) EP2197878B1 (zh)
JP (5) JP5452490B2 (zh)
CN (1) CN101848908B (zh)
CA (1) CA2736177A1 (zh)
CY (1) CY1118012T1 (zh)
DK (1) DK2197878T3 (zh)
ES (2) ES2591028T3 (zh)
HK (2) HK1148529A1 (zh)
HR (1) HRP20161114T1 (zh)
HU (1) HUE030774T2 (zh)
LT (1) LT2197878T (zh)
PL (1) PL2197878T3 (zh)
PT (1) PT2197878T (zh)
SI (1) SI2197878T1 (zh)
WO (1) WO2009033033A2 (zh)

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CA2736177A1 (en) * 2007-09-06 2009-03-12 Boston Biomedical, Inc. Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
CN101971690B (zh) * 2007-12-10 2016-04-20 交互数字专利控股公司 用于触发无线电链路控制分组丢弃和无线电链路控制重建的方法和设备
CA2865819A1 (en) 2011-02-28 2013-09-07 Mcmaster University Treatment of cancer with dopamine receptor antagonists
ES2609459T3 (es) * 2012-08-23 2017-04-20 The Institute Of Cancer Research : The Royal Cancer Hospital Compuestos heterocíclicos condensados y su uso
CA2904152A1 (en) * 2013-03-13 2014-10-02 Boston Biomedical, Inc. 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer
US9227962B2 (en) 2013-03-13 2016-01-05 Boston Biomedical, Inc. Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative
US9187454B2 (en) 2013-03-13 2015-11-17 Boston Biomedical, Inc. Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof
WO2014202528A1 (en) * 2013-06-20 2014-12-24 Boehringer Ingelheim International Gmbh Olefin substituted oxindoles having ampk activity
JP6472096B2 (ja) * 2014-01-27 2019-02-20 ボストン バイオメディカル， インコーポレイテッド 癌を処置するための新規方法
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
EA201792320A1 (ru) * 2015-04-27 2018-02-28 Бостон Биомедикал, Инк. Способ лечения рака ингибитором пути stat3 и ингибитором киназы
JPWO2017026119A1 (ja) * 2015-08-10 2018-05-24 大日本住友製薬株式会社 ５−（チアゾール−４−イル）インドリン−２−オン誘導体の精製方法
WO2017160978A1 (en) 2016-03-15 2017-09-21 Boston Biomedical, Inc. Cell cultures and use thereof
CA3029596A1 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
MX2021003156A (es) * 2018-09-18 2021-05-14 1 Globe Biomedical Co Ltd Tratamiento para la enfermedad del higado graso no alcoholico.
CN112996507B (zh) * 2018-09-18 2023-09-05 北京强新生物科技有限公司 肥胖症的治疗
WO2023081923A1 (en) 2021-11-08 2023-05-11 Frequency Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof

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US9187454B2 (en) * 2013-03-13 2015-11-17 Boston Biomedical, Inc. Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof

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WO2009033033A2 (en) 2009-03-12
JP2019070051A (ja) 2019-05-09
CY1118012T1 (el) 2017-05-17
US9725444B2 (en) 2017-08-08
EP3037419A1 (en) 2016-06-29
CA2736177A1 (en) 2009-03-12
US20190248781A1 (en) 2019-08-15
JP2010538091A (ja) 2010-12-09
ES2759347T3 (es) 2020-05-08
JP5974124B2 (ja) 2016-08-23
US20120321622A1 (en) 2012-12-20
HRP20161114T1 (hr) 2016-11-04
LT2197878T (lt) 2016-09-26
US20150197517A1 (en) 2015-07-16
PT2197878T (pt) 2016-11-04
US8299106B2 (en) 2012-10-30
EP3037419B1 (en) 2019-09-04
SI2197878T1 (sl) 2016-10-28
EP2197878A4 (en) 2012-02-08
JP5452490B2 (ja) 2014-03-26
JP6495868B2 (ja) 2019-04-03
EP2197878A2 (en) 2010-06-23
US20180022743A1 (en) 2018-01-25
ES2591028T3 (es) 2016-11-24
EP2197878B1 (en) 2016-08-17
PL2197878T3 (pl) 2017-01-31
DK2197878T3 (en) 2016-11-14
WO2009033033A3 (en) 2009-04-30
JP2016180013A (ja) 2016-10-13
HUE030774T2 (hu) 2017-05-29
CN101848908A (zh) 2010-09-29
JP2014058573A (ja) 2014-04-03
JP5701372B2 (ja) 2015-04-15
JP2015129152A (ja) 2015-07-16
CN101848908B (zh) 2014-07-02
HK1226071A1 (zh) 2017-09-22
US20100285006A1 (en) 2010-11-11

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