HK1139936A1 - Substituted pyrimidodiazepines useful as plk1 inhibitors - Google Patents

Substituted pyrimidodiazepines useful as plk1 inhibitors

Info

Publication number
HK1139936A1
HK1139936A1 HK10106507.1A HK10106507A HK1139936A1 HK 1139936 A1 HK1139936 A1 HK 1139936A1 HK 10106507 A HK10106507 A HK 10106507A HK 1139936 A1 HK1139936 A1 HK 1139936A1
Authority
HK
Hong Kong
Prior art keywords
pyrimidodiazepines
substituted
useful
plk1 inhibitors
plk1
Prior art date
Application number
HK10106507.1A
Other languages
English (en)
Inventor
Jianping Cai
Shaoqing Chen
Xin-Jie Chu
Kang Le
Kin-Chun Thomas Luk
Peter Michael Wovkulich
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1139936(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of HK1139936A1 publication Critical patent/HK1139936A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
HK10106507.1A 2007-03-22 2010-07-05 Substituted pyrimidodiazepines useful as plk1 inhibitors HK1139936A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91935807P 2007-03-22 2007-03-22
PCT/EP2008/052847 WO2008113711A1 (en) 2007-03-22 2008-03-11 Substituted pyrimidodiazepines useful as plk1 inhibitors

Publications (1)

Publication Number Publication Date
HK1139936A1 true HK1139936A1 (en) 2010-09-30

Family

ID=39415299

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10106507.1A HK1139936A1 (en) 2007-03-22 2010-07-05 Substituted pyrimidodiazepines useful as plk1 inhibitors

Country Status (24)

Country Link
US (1) US7517873B2 (zh)
EP (1) EP2139892B1 (zh)
JP (1) JP5087640B2 (zh)
KR (1) KR101157848B1 (zh)
CN (2) CN102746175B (zh)
AR (1) AR065794A1 (zh)
AT (1) ATE524472T1 (zh)
AU (1) AU2008228303B2 (zh)
BR (1) BRPI0809088A2 (zh)
CA (1) CA2680757A1 (zh)
CL (1) CL2008000785A1 (zh)
CY (1) CY1112102T1 (zh)
DK (1) DK2139892T3 (zh)
ES (1) ES2371832T3 (zh)
HK (1) HK1139936A1 (zh)
HR (1) HRP20110807T1 (zh)
IL (1) IL200617A (zh)
MX (1) MX2009010034A (zh)
PE (1) PE20120495A1 (zh)
PL (1) PL2139892T3 (zh)
PT (1) PT2139892E (zh)
SI (1) SI2139892T1 (zh)
TW (1) TWI363629B (zh)
WO (1) WO2008113711A1 (zh)

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WO2009023269A2 (en) * 2007-08-15 2009-02-19 Vertex Pharmaceuticals Incorporated 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5h-pyrimido [4, 5-b[1, 4] diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases
GEP20125704B (en) 2007-09-25 2012-12-10 Takeda Pharmaceuticals Co Plk kinase inhibitors
ES2585110T3 (es) * 2007-09-28 2016-10-03 Cyclacel Limited Derivados de pirimidina como inhibidores de proteína cinasa
WO2009067547A1 (en) * 2007-11-19 2009-05-28 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
JP2011527667A (ja) * 2008-06-18 2011-11-04 武田薬品工業株式会社 ハロ置換ピリミドジアゼピン
TWI432436B (zh) 2008-12-09 2014-04-01 Gilead Sciences Inc 類鐸受體的調節劑
JP5908728B2 (ja) * 2009-01-06 2016-04-26 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ピリミド−ジアゼピノンキナーゼ骨格化合物及び疾患を治療する方法
KR101702609B1 (ko) 2009-06-17 2017-02-03 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
EP2477987B1 (en) 2009-09-14 2018-01-10 Gilead Sciences, Inc. Modulators of toll-like receptors
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3388436B1 (en) 2013-03-15 2020-08-12 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
KR20160034379A (ko) 2013-07-25 2016-03-29 다나-파버 캔서 인스티튜트 인크. 전사 인자의 억제제 및 그의 용도
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
RU2019104421A (ru) 2013-11-13 2019-04-17 Вертекс Фармасьютикалз Инкорпорейтед Способы получения ингибиторов репликации вирусов гриппа
NZ719729A (en) 2013-11-13 2022-04-29 Vertex Pharma Inhibitors of influenza viruses replication
EP3099693A4 (en) * 2014-01-31 2017-08-16 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
CA2936865A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
EP3166607B1 (en) 2014-07-11 2022-08-31 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
CN106715437A (zh) 2014-08-08 2017-05-24 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
SG11201701472VA (en) 2014-09-16 2017-04-27 Gilead Sciences Inc Methods of preparing toll-like receptor modulators
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
WO2017044849A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
PE20181086A1 (es) 2015-09-11 2018-07-05 Dana Farber Cancer Inst Inc Acetamida tienotrizolodiazepinas y usos de las mismas
SG10201913450PA (en) 2015-11-25 2020-03-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
CN109311901A (zh) * 2016-04-07 2019-02-05 达纳-法伯癌症研究所有限公司 嘧啶并-二氮杂卓酮激酶骨架化合物及治疗pi3k介导的病变的方法
US20220378919A1 (en) * 2019-09-27 2022-12-01 Dana-Farber Cancer Institute, Inc. Erk5 degraders as therapeutics in cancer and inflammatory diseases
KR102313753B1 (ko) * 2020-03-27 2021-10-19 (주) 업테라 Plk1의 선택적 분해를 유도하는 바닐린 유도체 화합물
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL354241A1 (en) 1999-09-17 2003-12-29 Abbott Gmbh & Co.Kgabbott Gmbh & Co.Kg Kinase inhibitors as therapeutic agents
UA76512C2 (en) 2001-09-04 2006-08-15 Boehringer Ingelheim Pharma Dihydropteridinones, a method for producing thereof and use thereof as medicament
JP5243970B2 (ja) * 2006-02-14 2013-07-24 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼの阻害剤として有用なジヒドロジアゼピン
TW200808325A (en) * 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
AR065794A1 (es) 2009-07-01
CA2680757A1 (en) 2008-09-25
CY1112102T1 (el) 2015-11-04
CN102746175A (zh) 2012-10-24
CL2008000785A1 (es) 2009-03-27
TW200843781A (en) 2008-11-16
WO2008113711A1 (en) 2008-09-25
HRP20110807T1 (hr) 2011-12-31
CN101636399A (zh) 2010-01-27
EP2139892A1 (en) 2010-01-06
PE20120495A1 (es) 2012-05-12
US20080234255A1 (en) 2008-09-25
US7517873B2 (en) 2009-04-14
IL200617A (en) 2014-02-27
KR101157848B1 (ko) 2012-07-11
TWI363629B (en) 2012-05-11
PL2139892T3 (pl) 2012-03-30
AU2008228303B2 (en) 2012-04-19
DK2139892T3 (da) 2011-12-12
ES2371832T3 (es) 2012-01-10
CN101636399B (zh) 2012-04-18
ATE524472T1 (de) 2011-09-15
AU2008228303A1 (en) 2008-09-25
JP5087640B2 (ja) 2012-12-05
MX2009010034A (es) 2009-10-12
JP2010521514A (ja) 2010-06-24
CN102746175B (zh) 2014-01-15
EP2139892B1 (en) 2011-09-14
SI2139892T1 (sl) 2011-12-30
BRPI0809088A2 (pt) 2014-09-09
KR20090119913A (ko) 2009-11-20
PT2139892E (pt) 2011-11-21
IL200617A0 (en) 2010-05-17

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150311