HK1138602A1 - Sequence based engineering and optimization of single chain antibodies - Google Patents

Sequence based engineering and optimization of single chain antibodies

Info

Publication number
HK1138602A1
HK1138602A1 HK10103877.0A HK10103877A HK1138602A1 HK 1138602 A1 HK1138602 A1 HK 1138602A1 HK 10103877 A HK10103877 A HK 10103877A HK 1138602 A1 HK1138602 A1 HK 1138602A1
Authority
HK
Hong Kong
Prior art keywords
optimization
single chain
chain antibodies
sequence based
based engineering
Prior art date
Application number
HK10103877.0A
Other languages
English (en)
Inventor
David Urech
Leonardo Borras
Original Assignee
Esbatech A Novartis Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech A Novartis Co Llc filed Critical Esbatech A Novartis Co Llc
Publication of HK1138602A1 publication Critical patent/HK1138602A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK10103877.0A 2007-03-12 2010-04-21 Sequence based engineering and optimization of single chain antibodies HK1138602A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90636507P 2007-03-12 2007-03-12
PCT/EP2008/001958 WO2008110348A1 (fr) 2007-03-12 2008-03-12 Ingénierie et optimisation basées sur la séquence d'anticorps à une seule chaîne

Publications (1)

Publication Number Publication Date
HK1138602A1 true HK1138602A1 (en) 2010-08-27

Family

ID=39586970

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10103877.0A HK1138602A1 (en) 2007-03-12 2010-04-21 Sequence based engineering and optimization of single chain antibodies

Country Status (12)

Country Link
US (2) US8280711B2 (fr)
EP (2) EP2118138A1 (fr)
JP (1) JP5622397B2 (fr)
CN (2) CN101668771B (fr)
AU (1) AU2008226067B2 (fr)
CA (1) CA2680564C (fr)
HK (1) HK1138602A1 (fr)
IL (1) IL200710A (fr)
IN (1) IN2009DN05758A (fr)
NZ (1) NZ579594A (fr)
RU (2) RU2009137582A (fr)
WO (1) WO2008110348A1 (fr)

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AU2021329374A1 (en) 2020-08-20 2023-03-09 Amgen Inc. Antigen binding proteins with non-canonical disulfide in FAB region
CA3197047A1 (fr) 2020-10-07 2022-04-14 Amgen Inc. Selection rationnelle de blocs de construction pour l'assemblage d'anticorps multispecifiques
EP4244246A1 (fr) 2020-11-10 2023-09-20 Amgen Inc. Nouveaux lieurs de domaines de liaison à l'antigène multispécifiques
CN116848136A (zh) 2021-02-12 2023-10-03 勃林格殷格翰国际有限公司 补体c3抗原结合蛋白
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Also Published As

Publication number Publication date
JP2010523077A (ja) 2010-07-15
US9938336B2 (en) 2018-04-10
EP3202786A3 (fr) 2017-10-11
CA2680564A1 (fr) 2008-09-18
WO2008110348A1 (fr) 2008-09-18
NZ579594A (en) 2012-03-30
JP5622397B2 (ja) 2014-11-12
CN103275216A (zh) 2013-09-04
IL200710A (en) 2014-07-31
EP3202786A2 (fr) 2017-08-09
AU2008226067A1 (en) 2008-09-18
US20130053259A1 (en) 2013-02-28
US8280711B2 (en) 2012-10-02
US20100137150A1 (en) 2010-06-03
IN2009DN05758A (fr) 2015-07-24
CA2680564C (fr) 2018-05-01
AU2008226067B2 (en) 2012-11-08
IL200710A0 (en) 2010-05-17
RU2014127308A (ru) 2016-02-10
CN101668771B (zh) 2013-08-21
CN101668771A (zh) 2010-03-10
CN103275216B (zh) 2015-05-06
RU2009137582A (ru) 2011-04-20
EP2118138A1 (fr) 2009-11-18

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