HK1138568A1 - [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation [f-18]- l-[f-18]- l- - Google Patents

[f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation [f-18]- l-[f-18]- l-

Info

Publication number
HK1138568A1
HK1138568A1 HK10105265.5A HK10105265A HK1138568A1 HK 1138568 A1 HK1138568 A1 HK 1138568A1 HK 10105265 A HK10105265 A HK 10105265A HK 1138568 A1 HK1138568 A1 HK 1138568A1
Authority
HK
Hong Kong
Prior art keywords
labeled
glutamine
derivatives
processes
preparation
Prior art date
Application number
HK10105265.5A
Other languages
English (en)
Chinese (zh)
Inventor
‧丁克爾博格
‧弗里貝
‧克拉西科娃
‧别洛孔
‧庫茲涅左娃
‧格雷厄姆
‧萊曼
‧伯恩特
‧施密特-維利希
Original Assignee
拜耳先靈醫藥股份有限公司
俄羅斯科學院元素有機化合物研究所
俄羅斯聯邦
俄羅斯科學院人類大腦研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2006138584/04A external-priority patent/RU2395489C2/ru
Priority claimed from EP06090211A external-priority patent/EP1923382A1/fr
Application filed by 拜耳先靈醫藥股份有限公司, 俄羅斯科學院元素有機化合物研究所, 俄羅斯聯邦, 俄羅斯科學院人類大腦研究所 filed Critical 拜耳先靈醫藥股份有限公司
Publication of HK1138568A1 publication Critical patent/HK1138568A1/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK10105265.5A 2006-11-01 2010-05-28 [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation [f-18]- l-[f-18]- l- HK1138568A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2006138584/04A RU2395489C2 (ru) 2006-11-01 2006-11-01 [f-18] меченная l-глютаминовая кислота, [f-18] меченный l-глютамин, их производные и их применение, а также способ их получения
EP06090211A EP1923382A1 (fr) 2006-11-18 2006-11-18 L-acide glutamique marqué au fluor 18, glutamine marquée au fluor 18, leurs derivés ainsi que procédés de leur préparation
PCT/EP2007/009518 WO2008052788A1 (fr) 2006-11-01 2007-10-30 Acide l-glutamique marqué au [f-18], l-glutamine marquée au [f-18], leurs dérivés et leur utilisation, ainsi que leur procédé de fabrication

Publications (1)

Publication Number Publication Date
HK1138568A1 true HK1138568A1 (en) 2010-08-27

Family

ID=38896929

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10105265.5A HK1138568A1 (en) 2006-11-01 2010-05-28 [f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, derivatives thereof and use thereof and processes for their preparation [f-18]- l-[f-18]- l-

Country Status (24)

Country Link
US (2) US20100217011A1 (fr)
EP (1) EP2086924B1 (fr)
JP (4) JP5529540B2 (fr)
KR (1) KR101495924B1 (fr)
CN (1) CN101595083B (fr)
AR (1) AR071043A1 (fr)
AU (1) AU2007315203B2 (fr)
BR (1) BRPI0718055A2 (fr)
CA (1) CA2667395C (fr)
CL (2) CL2007003169A1 (fr)
CO (1) CO6180453A2 (fr)
CU (1) CU23825B1 (fr)
EA (1) EA017713B1 (fr)
EC (1) ECSP099304A (fr)
ES (1) ES2701423T3 (fr)
HK (1) HK1138568A1 (fr)
IL (1) IL198022A0 (fr)
MX (1) MX2009004686A (fr)
NO (1) NO20092123L (fr)
NZ (1) NZ576582A (fr)
PE (1) PE20091723A1 (fr)
SV (1) SV2009003251A (fr)
TW (1) TWI415626B (fr)
WO (1) WO2008052788A1 (fr)

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CA2667395C (fr) 2006-11-01 2016-05-10 Bayer Schering Pharma Aktiengesellschaft Acide l-glutamique marque au [f-18], l-glutamine marquee au [f-18], leurs derives et leur utilisation, ainsi que leur procede de fabrication
EP2123621A1 (fr) * 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Nouveaux acides de glutamine L marqués au {F-18} et dérivés de glutamine L (I), leur utilisation et leur procédé de fabrication
EP2123620A1 (fr) * 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Dérivés de l'acide L-glutamique marqué en {F-19} et de L-glutamine (III), leur utilisation et procédé pour les obtenir
EP2123619A1 (fr) * 2008-05-20 2009-11-25 Bayer Schering Pharma AG Nouveaux acides de glutamine L marqués au [F-18] et dérivés de glutamine L (II), leur utilisation et leur procédé de fabrication
PL2346870T3 (pl) * 2008-10-10 2016-01-29 Merck & Cie Foliany znakowane fluorem-18 jako radioznaczniki pet
US8722014B2 (en) * 2009-05-01 2014-05-13 Washington University 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof
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EP2322171A3 (fr) * 2009-11-17 2011-06-01 Bayer Schering Pharma Aktiengesellschaft Dérives de l'acide L-glutamique marqués au fluor
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EP2520556A1 (fr) 2011-05-03 2012-11-07 Bayer Pharma Aktiengesellschaft Acides aminés radiomarqués pour imagerie de diagnostic
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WO2020010228A1 (fr) * 2018-07-06 2020-01-09 The Regents Of The University Of California Procédés et composés de fonctionnalisation déconstructive
CN109369445B (zh) * 2018-11-20 2021-10-15 首都医科大学 用于诊断和治疗的放射性谷氨酰胺衍生物及其制备方法

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EP1923382A1 (fr) 2006-11-18 2008-05-21 Bayer Schering Pharma Aktiengesellschaft L-acide glutamique marqué au fluor 18, glutamine marquée au fluor 18, leurs derivés ainsi que procédés de leur préparation
CA2667395C (fr) 2006-11-01 2016-05-10 Bayer Schering Pharma Aktiengesellschaft Acide l-glutamique marque au [f-18], l-glutamine marquee au [f-18], leurs derives et leur utilisation, ainsi que leur procede de fabrication
EP2123621A1 (fr) 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Nouveaux acides de glutamine L marqués au {F-18} et dérivés de glutamine L (I), leur utilisation et leur procédé de fabrication
EP2123619A1 (fr) * 2008-05-20 2009-11-25 Bayer Schering Pharma AG Nouveaux acides de glutamine L marqués au [F-18] et dérivés de glutamine L (II), leur utilisation et leur procédé de fabrication
EP2123620A1 (fr) 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Dérivés de l'acide L-glutamique marqué en {F-19} et de L-glutamine (III), leur utilisation et procédé pour les obtenir

Also Published As

Publication number Publication date
JP5749836B2 (ja) 2015-07-15
PE20091723A1 (es) 2009-12-11
TW200920407A (en) 2009-05-16
CL2012000768A1 (es) 2012-09-14
CU20090072A7 (es) 2011-09-21
US20100217011A1 (en) 2010-08-26
JP2014088389A (ja) 2014-05-15
KR101495924B1 (ko) 2015-02-25
IL198022A0 (en) 2009-12-24
US20140301948A1 (en) 2014-10-09
EP2086924A1 (fr) 2009-08-12
JP5815651B2 (ja) 2015-11-17
EA200970428A1 (ru) 2009-12-30
CN101595083A (zh) 2009-12-02
CA2667395C (fr) 2016-05-10
TWI415626B (zh) 2013-11-21
AR071043A1 (es) 2010-05-26
AU2007315203B2 (en) 2013-06-27
NO20092123L (no) 2009-07-30
CO6180453A2 (es) 2010-07-19
EA017713B1 (ru) 2013-02-28
CN101595083B (zh) 2014-12-10
NZ576582A (en) 2011-12-22
ECSP099304A (es) 2009-07-31
MX2009004686A (es) 2009-09-28
KR20090096597A (ko) 2009-09-11
US9375497B2 (en) 2016-06-28
EP2086924B1 (fr) 2018-09-12
BRPI0718055A2 (pt) 2013-11-05
AU2007315203A1 (en) 2008-05-08
CU23825B1 (es) 2012-06-21
CL2007003169A1 (es) 2008-07-04
JP5529540B2 (ja) 2014-06-25
JP2014221764A (ja) 2014-11-27
SV2009003251A (es) 2009-12-15
ES2701423T3 (es) 2019-02-22
JP2010508317A (ja) 2010-03-18
WO2008052788A1 (fr) 2008-05-08
JP2014062113A (ja) 2014-04-10
CA2667395A1 (fr) 2008-05-08

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