HK1138326A1 - Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells - Google Patents

Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells

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Publication number
HK1138326A1
HK1138326A1 HK10105130.8A HK10105130A HK1138326A1 HK 1138326 A1 HK1138326 A1 HK 1138326A1 HK 10105130 A HK10105130 A HK 10105130A HK 1138326 A1 HK1138326 A1 HK 1138326A1
Authority
HK
Hong Kong
Prior art keywords
bacterially
derived
nucleic acid
mammalian cells
vivo delivery
Prior art date
Application number
HK10105130.8A
Other languages
English (en)
Chinese (zh)
Inventor
Himanshu Brahmbhatt
Jennifer Macdiarmid
Toby Hulf
Original Assignee
Engeneic Molecular Delivery Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engeneic Molecular Delivery Pty Ltd filed Critical Engeneic Molecular Delivery Pty Ltd
Publication of HK1138326A1 publication Critical patent/HK1138326A1/xx

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11021—Polo kinase (2.7.11.21)
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
    • C—CHEMISTRY; METALLURGY
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
HK10105130.8A 2007-03-30 2010-05-25 Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells HK1138326A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90907407P 2007-03-30 2007-03-30
PCT/IB2008/002984 WO2009027830A2 (fr) 2007-03-30 2008-03-26 Minicellules intactes d'origine bactérienne englobant un acide nucléique fonctionnel exempt de plasmide pour administration in vivo à des cellules de mammifère

Publications (1)

Publication Number Publication Date
HK1138326A1 true HK1138326A1 (en) 2010-08-20

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HK10105130.8A HK1138326A1 (en) 2007-03-30 2010-05-25 Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
HK15110506.9A HK1209786A1 (en) 2007-03-30 2015-10-26 Bacterially derived, intact minicells encompassing regulatory rna rna

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HK15110506.9A HK1209786A1 (en) 2007-03-30 2015-10-26 Bacterially derived, intact minicells encompassing regulatory rna rna

Country Status (18)

Country Link
EP (5) EP2145002B1 (fr)
JP (1) JP5167338B2 (fr)
CN (2) CN101715489B (fr)
AU (1) AU2008291833B2 (fr)
CA (3) CA2933978C (fr)
CY (1) CY1119031T1 (fr)
DK (2) DK2145002T3 (fr)
ES (2) ES2534435T3 (fr)
HK (2) HK1138326A1 (fr)
HR (2) HRP20150328T1 (fr)
LT (1) LT2865755T (fr)
MX (1) MX2009010411A (fr)
NZ (1) NZ580487A (fr)
PL (2) PL2865755T3 (fr)
PT (2) PT2145002E (fr)
SG (2) SG10201507969PA (fr)
SI (2) SI2145002T1 (fr)
WO (1) WO2009027830A2 (fr)

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SG10201507969PA (en) * 2007-03-30 2015-10-29 Engeneic Molecular Delivery Pty Ltd Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells

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HRP20170662T1 (hr) 2017-07-14
SG10201804257RA (en) 2018-06-28
SG10201507969PA (en) 2015-10-29
AU2008291833B2 (en) 2012-11-08
EP3205724B1 (fr) 2019-05-08
CA2844647C (fr) 2016-07-26
JP2010523487A (ja) 2010-07-15
CN105854029A (zh) 2016-08-17
EP2145002A2 (fr) 2010-01-20
CA2844647A1 (fr) 2009-03-05
PL2145002T3 (pl) 2015-06-30
SI2145002T1 (sl) 2015-05-29
EP2865755A3 (fr) 2015-05-06
PL2865755T3 (pl) 2017-08-31
CA2682704C (fr) 2014-07-08
AU2008291833A1 (en) 2009-03-05
DK2865755T3 (en) 2017-05-15
DK2145002T3 (en) 2015-04-20
CN101715489A (zh) 2010-05-26
CA2933978A1 (fr) 2009-03-05
EP2532746A3 (fr) 2013-08-14
WO2009027830A2 (fr) 2009-03-05
JP5167338B2 (ja) 2013-03-21
MX2009010411A (es) 2009-11-23
HRP20150328T1 (hr) 2015-05-22
EP2145002B1 (fr) 2015-01-07
CA2682704A1 (fr) 2009-03-05
WO2009027830A3 (fr) 2009-05-14
EP2532746A2 (fr) 2012-12-12
CY1119031T1 (el) 2018-01-10
CN101715489B (zh) 2016-05-25
NZ580487A (en) 2012-04-27
EP3205724A1 (fr) 2017-08-16
PT2865755T (pt) 2017-05-26
ES2626179T3 (es) 2017-07-24
HK1209786A1 (en) 2016-04-08
EP3564372A1 (fr) 2019-11-06
ES2534435T3 (es) 2015-04-22
LT2865755T (lt) 2017-07-25
SI2865755T1 (sl) 2017-06-30
PT2145002E (pt) 2015-04-29
CA2933978C (fr) 2018-08-21
EP2865755B1 (fr) 2017-02-01
CN105854029B (zh) 2019-10-18
EP2865755A2 (fr) 2015-04-29

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